| Programmable base editing of A• T to G• C in genomic DNA without DNA cleavage NM Gaudelli, AC Komor, HA Rees, MS Packer, AH Badran, DI Bryson, ... Nature 551 (7681), 464-471, 2017 | 3818 | 2017 |
| Evolved Cas9 variants with broad PAM compatibility and high DNA specificity JH Hu, SM Miller, MH Geurts, W Tang, L Chen, N Sun, CM Zeina, X Gao, ... Nature 556 (7699), 57-63, 2018 | 1615 | 2018 |
| Base editing: precision chemistry on the genome and transcriptome of living cells HA Rees, DR Liu Nature reviews genetics 19 (12), 770-788, 2018 | 1496 | 2018 |
| CRISPResso2 provides accurate and rapid genome editing sequence analysis K Clement, H Rees, MC Canver, JM Gehrke, R Farouni, JY Hsu, MA Cole, ... Nature biotechnology 37 (3), 224-226, 2019 | 1102 | 2019 |
| Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles M Wang, JA Zuris, F Meng, H Rees, S Sun, P Deng, Y Han, X Gao, ... Proceedings of the National Academy of Sciences 113 (11), 2868-2873, 2016 | 644 | 2016 |
| Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery HA Rees, AC Komor, WH Yeh, J Caetano-Lopes, M Warman, ASB Edge, ... Nature communications 8 (1), 15790, 2017 | 486 | 2017 |
| Directed evolution of adenine base editors with increased activity and therapeutic application NM Gaudelli, DK Lam, HA Rees, NM Solá-Esteves, LA Barrera, DA Born, ... Nature biotechnology 38 (7), 892-900, 2020 | 473 | 2020 |
| Continuous evolution of SpCas9 variants compatible with non-G PAMs SM Miller, T Wang, PB Randolph, M Arbab, MW Shen, TP Huang, ... Nature biotechnology 38 (4), 471-481, 2020 | 325 | 2020 |
| Analysis and minimization of cellular RNA editing by DNA adenine base editors HA Rees, C Wilson, JL Doman, DR Liu Science advances 5 (5), eaax5717, 2019 | 261 | 2019 |
| In vivo base editing of post-mitotic sensory cells WH Yeh, H Chiang, HA Rees, ASB Edge, DR Liu Nature communications 9 (1), 2184, 2018 | 232 | 2018 |
| Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity Y Yu, TC Leete, DA Born, L Young, LA Barrera, SJ Lee, HA Rees, ... Nature Communications 11 (1), 2052, 2020 | 176 | 2020 |
| Phage-assisted continuous evolution of proteases with altered substrate specificity MS Packer, HA Rees, DR Liu Nature Communications 8 (1), 956, 2017 | 127 | 2017 |
| Development of hRad51–Cas9 nickase fusions that mediate HDR without double-stranded breaks HA Rees, WH Yeh, DR Liu Nature communications 10 (1), 2212, 2019 | 105 | 2019 |
| Nucleobase editors and uses thereof DR Liu, AC Komor, HA Rees, Y Kim US Patent 10,167,457, 2019 | 86 | 2019 |
| Mechanism of nonsense-mediated mRNA decay stimulation by splicing factor SRSF1 I Aznarez, TT Nomakuchi, J Tetenbaum-Novatt, MA Rahman, O Fregoso, ... Cell reports 23 (7), 2186-2198, 2018 | 80 | 2018 |
| Rationally designed base editors for precise editing of the sickle cell disease mutation SH Chu, M Packer, H Rees, D Lam, Y Yu, J Marshall, LI Cheng, D Lam, ... The CRISPR Journal 4 (2), 169-177, 2021 | 71 | 2021 |
| Green fluorescent proteins engineered for cartilage-targeted drug delivery: Insights for transport into highly charged avascular tissues Y Krishnan, HA Rees, CP Rossitto, SE Kim, HHK Hung, EH Frank, ... Biomaterials 183, 218-233, 2018 | 65 | 2018 |
| Nucleobase editors comprising nucleic acid programmable DNA binding proteins DR Liu, AC Komor, L Chen, HA Rees US Patent 11,268,082, 2022 | 58 | 2022 |
| Structural and evolutionary versatility in protein complexes with uneven stoichiometry JA Marsh, HA Rees, SE Ahnert, SA Teichmann Nature communications 6 (1), 6394, 2015 | 52 | 2015 |
| Nucleobase editors and uses thereof DR Liu, AC Komor, HA Rees, Y Kim US Patent 11,214,780, 2022 | 42 | 2022 |
