| Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium … R Gande, KJC Gibson, AK Brown, K Krumbach, LG Dover, H Sahm, ... Journal of Biological Chemistry 279 (43), 44847-44857, 2004 | 210 | 2004 |
| Mycolic acid biosynthesis and enzymic characterization of the β-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis L Kremer, LG Dover, S Carrère, KM Nampoothiri, S Lesjean, AK Brown, ... Biochemical Journal 364 (2), 423-430, 2002 | 156 | 2002 |
| Functional Role of the PE Domain and Immunogenicity of the Mycobacterium tuberculosis Triacylglycerol Hydrolase LipY KC Mishra, C De Chastellier, Y Narayana, P Bifani, AK Brown, GS Besra, ... Infection and immunity 76 (1), 127-140, 2008 | 155 | 2008 |
| VapC20 of Mycobacterium tuberculosis cleaves the Sarcin–Ricin loop of 23S rRNA KS Winther, DE Brodersen, AK Brown, K Gerdes Nature communications 4 (1), 2796, 2013 | 142 | 2013 |
| The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation V Molle, AK Brown, GS Besra, AJ Cozzone, L Kremer Journal of Biological Chemistry 281 (40), 30094-30103, 2006 | 127 | 2006 |
| Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II AK Brown, A Papaemmanouil, V Bhowruth, A Bhatt, LG Dover, GS Besra Microbiology 153 (10), 3314-3322, 2007 | 108 | 2007 |
| Two functional FAS-I type fatty acid synthases in Corynebacterium glutamicum E Radmacher, LJ Alderwick, GS Besra, AK Brown, KJC Gibson, H Sahm, ... Microbiology 151 (7), 2421-2427, 2005 | 106 | 2005 |
| The Mycobacterium tuberculosis β-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue R Veyron-Churlet, V Molle, RC Taylor, AK Brown, GS Besra, ... Journal of Biological Chemistry 284 (10), 6414-6424, 2009 | 88 | 2009 |
| Probing the mechanism of the Mycobacterium tuberculosis β-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity AK Brown, S Sridharan, L Kremer, S Lindenberg, LG Dover, ... Journal of Biological Chemistry 280 (37), 32539-32547, 2005 | 85 | 2005 |
| Identification of 2-Aminothiazole-4-Carboxylate Derivatives Active against Mycobacterium tuberculosis H37Rv and the β-Ketoacyl-ACP Synthase mtFabH Q Al-Balas, NG Anthony, B Al-Jaidi, A Alnimr, G Abbott, AK Brown, ... PLoS One 4 (5), e5617, 2009 | 80 | 2009 |
| Platensimycin activity against mycobacterial β-ketoacyl-ACP synthases AK Brown, RC Taylor, A Bhatt, K Fütterer, GS Besra PLoS One 4 (7), e6306, 2009 | 79 | 2009 |
| Identification of the dehydratase component of the mycobacterial mycolic acid-synthesizing fatty acid synthase-II complex AK Brown, A Bhatt, A Singh, E Saparia, AF Evans, GS Besra Microbiology 153 (12), 4166-4173, 2007 | 70 | 2007 |
| Symmetrical and unsymmetrical analogues of isoxyl; active agents against Mycobacterium tuberculosis V Bhowruth, AK Brown, RC Reynolds, GD Coxon, SP Mackay, ... Bioorganic & medicinal chemistry letters 16 (18), 4743-4747, 2006 | 62 | 2006 |
| Loss of a mycobacterial gene encoding a reductase leads to an altered cell wall containing β-oxo-mycolic acid analogs and accumulation of ketones A Bhatt, AK Brown, A Singh, DE Minnikin, GS Besra Chemistry & biology 15 (9), 930-939, 2008 | 60 | 2008 |
| Design and Synthesis of 1-((1,5-Bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine (BM212) and N-Adamantan-2-yl-N′-((E)-3,7 … S Bhakta, N Scalacci, A Maitra, AK Brown, S Dasugari, D Evangelopoulos, ... Journal of medicinal chemistry 59 (6), 2780-2793, 2016 | 55 | 2016 |
| The rhodococcal cell envelope: composition, organisation and biosynthesis IC Sutcliffe, AK Brown, LG Dover Biology of Rhodococcus, 29-71, 2010 | 49 | 2010 |
| Regulation of cell wall synthesis and growth LG Dover, LJ Alderwick, AK Brown, K Futterer, GS Besra Current molecular medicine 7 (3), 247-276, 2007 | 43 | 2007 |
| X-ray crystal structure of Mycobacterium tuberculosis β-ketoacyl acyl carrier protein synthase II (mtKasB) S Sridharan, L Wang, AK Brown, LG Dover, L Kremer, GS Besra, ... Journal of molecular biology 366 (2), 469-480, 2007 | 41 | 2007 |
| Synthesis and SAR evaluation of novel thioridazine derivatives active against drug-resistant tuberculosis N Scalacci, AK Brown, FR Pavan, CM Ribeiro, F Manetti, S Bhakta, ... European journal of medicinal chemistry 127, 147-158, 2017 | 35 | 2017 |
| Synthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636 V Bhowruth, AK Brown, GS Besra Microbiology 154 (7), 1866-1875, 2008 | 33 | 2008 |
