The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3, 4, 5-triphosphate 5-phosphatase. JE Damen, L Liu, P Rosten, RK Humphries, AB Jefferson, PW Majerus, ... Proceedings of the National Academy of Sciences 93 (4), 1689-1693, 1996 | 819 | 1996 |
Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span CD Helgason, JE Damen, P Rosten, R Grewal, P Sorensen, SM Chappel, ... Genes & development 12 (11), 1610-1620, 1998 | 728 | 1998 |
Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival J Kalesnikoff, M Huber, V Lam, JE Damen, J Zhang, RP Siraganian, ... Immunity 14 (6), 801-811, 2001 | 493 | 2001 |
Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor β chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis T Yi, ALF Mui, G Krystal, JN Ihle Molecular and Cellular Biology 13 (12), 7577-7586, 1993 | 471 | 1993 |
The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation M Huber, CD Helgason, JE Damen, L Liu, RK Humphries, G Krystal Proceedings of the National Academy of Sciences 95 (19), 11330-11335, 1998 | 385 | 1998 |
LPS-induced upregulation of SHIP is essential for endotoxin tolerance LM Sly, MJ Rauh, J Kalesnikoff, CH Song, G Krystal Immunity 21 (2), 227-239, 2004 | 381 | 2004 |
Multiple pathways involved in the biosynthesis of anandamide J Liu, L Wang, J Harvey-White, BX Huang, HY Kim, S Luquet, RD Palmiter, ... Neuropharmacology 54 (1), 1-7, 2008 | 363 | 2008 |
SHIP represses the generation of alternatively activated macrophages MJ Rauh, V Ho, C Pereira, A Sham, LM Sly, V Lam, L Huxham, ... Immunity 23 (4), 361-374, 2005 | 337 | 2005 |
Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin‐induced cell proliferation and Stat5 activation. JE Damen, H Wakao, A Miyajima, J Krosl, RK Humphries, RL Cutler, ... The EMBO journal 14 (22), 5557-5568, 1995 | 332 | 1995 |
SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts S Takeshita, N Namba, JJ Zhao, Y Jiang, HK Genant, MJ Silva, MD Brodt, ... Nature medicine 8 (9), 943-949, 2002 | 294 | 2002 |
Inhibition of antigen‐induced T cell response and antibody‐induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP‐1 and SHP‐2 protein‐tyrosine phosphatases E Le Dréan, F Vély, L Olcese, A Cambiaggi, S Guia, G Krystal, N Gervois, ... European journal of immunology 28 (1), 264-276, 1998 | 293 | 1998 |
Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells. RL Cutler, L Liu, JE Damen, G Krystal Journal of Biological Chemistry 268 (29), 21463-21465, 1993 | 281 | 1993 |
Activin/TGF-β induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP H Valderrama-Carvajal, E Cocolakis, A Lacerte, EH Lee, G Krystal, S Ali, ... Nature cell biology 4 (12), 963-969, 2002 | 260 | 2002 |
Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein JE Damen, L Liu, RL Cutler, G Krystal | 255 | 1993 |
A simple microassay for erythropoietin based on 3H-thymidine incorporation into spleen cells from phenylhydrazine treated mice. G Krystal Experimental hematology 11 (7), 649-660, 1983 | 255 | 1983 |
Phosphatidylinositol (3, 4, 5) P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3, 4) P2 is required for PKB phosphorylation at … MP Scheid, M Huber, JE Damen, M Hughes, V Kang, P Neilsen, ... Journal of Biological Chemistry 277 (11), 9027-9035, 2002 | 227 | 2002 |
Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc L Liu, JE Damen, RL Cutler, G Krystal Molecular and cellular biology 14 (10), 6926-6935, 1994 | 223 | 1994 |
Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP. GW Chacko, S Tridandapani, JE Damen, L Liu, G Krystal, KM Coggeshall Journal of immunology (Baltimore, Md.: 1950) 157 (6), 2234-2238, 1996 | 215 | 1996 |
A dual role for Src homology 2 domain–containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of B lymphocytes in SHIP−/− mice CD Helgason, CP Kalberer, JE Damen, SM Chappel, N Pineault, ... The Journal of experimental medicine 191 (5), 781-794, 2000 | 208 | 2000 |
Phosphorylation of Tyrosine 503 in the Erythropoietin Receptor (EpR) Is Essential for Binding the P85 Subunit of Phosphatidylinositol (PI) 3-Kinase and for EpR-associated PI 3 … JE Damen, RL Cutler, H Jiao, T Yi, G Krystal Journal of Biological Chemistry 270 (40), 23402-23408, 1995 | 208 | 1995 |