| Crystal structure of human cytochrome P450 2C9 with bound warfarin PA Williams, J Cosme, A Ward, HC Angove, DM Vinković, H Jhoti Nature 424 (6947), 464-468, 2003 | 1044 | 2003 |
| Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone PA Williams, J Cosme, DM Vinković, A Ward, HC Angove, PJ Day, ... Science 305 (5684), 683-686, 2004 | 962 | 2004 |
| Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity PA Williams, J Cosme, V Sridhar, EF Johnson, DE McRee Molecular cell 5 (1), 121-131, 2000 | 954 | 2000 |
| Haem-ligand switching during catalysis in crystals of a nitrogen-cycle enzyme PA Williams, V Fülöp, EF Garman, NFW Saunders, SJ Ferguson, J Hajdu Nature 389 (6649), 406-412, 1997 | 326 | 1997 |
| Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO A Cleasby, J Yon, PJ Day, C Richardson, IJ Tickle, PA Williams, ... PloS one 9 (6), 2014 | 235 | 2014 |
| Microsomal cytochrome P450 2C5: comparison to microbial P450s and unique features PA Williams, J Cosme, V Sridhar, EF Johnson, DE McRee Journal of inorganic biochemistry 81 (3), 183-190, 2000 | 180 | 2000 |
| The Cu A domain of Thermus thermophilus ba 3-type cytochrome c oxidase at 1.6 Å resolution PA Williams, NJ Blackburn, D Sanders, H Bellamy, EA Stura, JA Fee, ... Nature structural biology 6 (6), 509-516, 1999 | 151 | 1999 |
| Complement regulation at the molecular level: the structure of decay-accelerating factor P Lukacik, P Roversi, J White, D Esser, GP Smith, J Billington, ... Proceedings of the National Academy of Sciences 101 (5), 1279-1284, 2004 | 146 | 2004 |
| Pseudospecific docking surfaces on electron transfer proteins as illustrated by pseudoazurin, cytochrome c 550 and cytochrome cd 1 nitrite reductase PA Williams, V Fülöp, YC Leung, C Chan, JWB Moir, G Howlett, ... Nature structural biology 2 (11), 975-982, 1995 | 133 | 1995 |
| High-Resolution Structure of the Soluble, Respiratory-Type Rieske Protein from Thermus thermophilus: Analysis and Comparison LM Hunsicker-Wang, A Heine, Y Chen, EP Luna, T Todaro, YM Zhang, ... Biochemistry 42 (24), 7303-7317, 2003 | 123 | 2003 |
| Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function SM Saalau-Bethell, AJ Woodhead, G Chessari, MG Carr, J Coyle, ... Nature chemical biology 8 (11), 920, 2012 | 122 | 2012 |
| Ferryl intermediates of catalase captured by time-resolved Weissenberg crystallography and UV-VIS spectroscopy P Gouet, HM Jouve, PA Williams, I Andersson, P Andreoletti, L Nussaume, ... Nature structural biology 3 (11), 951-956, 1996 | 98 | 1996 |
| Fragment-based drug discovery targeting inhibitor of apoptosis proteins: discovery of a non-alanine lead series with dual activity against cIAP1 and XIAP G Chessari, IM Buck, JEH Day, PJ Day, A Iqbal, CN Johnson, EJ Lewis, ... Journal of medicinal chemistry 58 (16), 6574-6588, 2015 | 93 | 2015 |
| Crystallographic and Biochemical Analyses of the Metal-Free Haemophilus influenzae Fe3+-Binding Protein CM Bruns, DS Anderson, KG Vaughan, PA Williams, AJ Nowalk, ... Biochemistry 40 (51), 15631-15637, 2001 | 88 | 2001 |
| Determination of the structure of a decay accelerating factor-binding clinical isolate of echovirus 11 allows mapping of mutants with altered receptor requirements for infection AD Stuart, TA McKee, PA Williams, C Harley, S Shen, DI Stuart, ... Journal of virology 76 (15), 7694-7704, 2002 | 73 | 2002 |
| Discovery of a potent nonpeptidomimetic, small-molecule antagonist of cellular inhibitor of apoptosis protein 1 (cIAP1) and X-linked inhibitor of apoptosis protein (XIAP) E Tamanini, IM Buck, G Chessari, E Chiarparin, JEH Day, M Frederickson, ... Journal of medicinal chemistry 60 (11), 4611-4625, 2017 | 70 | 2017 |
| Mapping CD55 Function THE STRUCTURE OF TWO PATHOGEN-BINDING DOMAINS AT 1.7 Å P Williams, Y Chaudhry, IG Goodfellow, J Billington, R Powell, OB Spiller, ... Journal of Biological Chemistry 278 (12), 10691-10696, 2003 | 70 | 2003 |
| Integrity of Thermus thermophilus cytochrome c 552 synthesized by Escherichia coli cells expressing the host-specific cytochrome c maturation genes, ccmABCDEFGH: Biochemical … JA Fee, Y Chen, TR Todaro, KL Bren, KM Patel, MG Hill, E Gomez-Moran, ... Protein Science 9 (11), 2074-2084, 2000 | 69 | 2000 |
| Outcome of the first wwPDB/CCDC/D3R ligand validation workshop PD Adams, K Aertgeerts, C Bauer, JA Bell, HM Berman, TN Bhat, ... Structure 24 (4), 502-508, 2016 | 68 | 2016 |
| Fragment-based drug discovery using cryo-EM M Saur, MJ Hartshorn, J Dong, J Reeks, G Bunkoczi, H Jhoti, PA Williams Drug Discovery Today, 2019 | 65 | 2019 |
