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Tessa Keenan
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Site-selective C–C modification of proteins at neutral pH using organocatalyst-mediated cross aldol ligations
RJ Spears, RL Brabham, D Budhadev, T Keenan, S McKenna, J Walton, ...
Chemical Science 9 (25), 5585-5593, 2018
452018
Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands
SJ Richards, T Keenan, JB Vendeville, DE Wheatley, H Chidwick, ...
Chemical science 12 (3), 905-910, 2021
282021
Cell-specific bioorthogonal tagging of glycoproteins
A Cioce, B Calle, T Rizou, SC Lowery, VL Bridgeman, KE Mahoney, ...
Nature Communications 13 (1), 6237, 2022
232022
Profiling substrate promiscuity of wild-type sugar kinases for multi-fluorinated monosaccharides
T Keenan, F Parmeggiani, J Malassis, CQ Fontenelle, JB Vendeville, ...
Cell Chemical Biology 27 (9), 1199-1206. e5, 2020
182020
Reconstitution and optimisation of the biosynthesis of bacterial sugar pseudaminic acid (Pse5Ac7Ac) enables preparative enzymatic synthesis of CMP-Pse5Ac7Ac
HS Chidwick, EKP Flack, T Keenan, J Walton, GH Thomas, MA Fascione
Scientific Reports 11 (1), 4756, 2021
162021
Characterization of the Streptomyces coelicolor glycoproteome reveals glycoproteins important for cell wall biogenesis
T Keenan, A Dowle, R Bates, MCM Smith
MBio 10 (3), 10.1128/mbio. 01092-19, 2019
142019
Rapid sodium periodate cleavage of an unnatural amino acid enables unmasking of a highly reactive α-oxo aldehyde for protein bioconjugation
RL Brabham, T Keenan, A Husken, J Bilsborrow, R McBerney, V Kumar, ...
Organic & Biomolecular Chemistry 18 (21), 4000-4003, 2020
122020
Biocatalytic transfer of pseudaminic acid (Pse5Ac7Ac) using promiscuous sialyltransferases in a chemoenzymatic approach to Pse5Ac7Ac-containing glycosides
EKP Flack, HS Chidwick, G Guchhait, T Keenan, D Budhadev, K Huang, ...
ACS Catalysis 10 (17), 9986-9993, 2020
112020
The characterisation of a galactokinase from Streptomyces coelicolor
T Keenan, R Mills, E Pocock, D Budhadev, F Parmeggiani, S Flitsch, ...
Carbohydrate research 472, 132-137, 2019
112019
Chemoenzymatic synthesis of 3-deoxy-3-fluoro-l-fucose and its enzymatic incorporation into glycoconjugates
P Valverde, JB Vendeville, K Hollingsworth, AP Mattey, T Keenan, ...
Chemical communications 56 (47), 6408-6411, 2020
82020
A Tale of Two Bioconjugations: pH Controlled Divergent Reactivity of Protein α-oxo-Aldehydes in Competing α-oxo-Mannich and Catalyst-Free Aldol Ligations
T Keenan, RJ Spears, S Akkad, CS Mahon, NE Hatton, J Walton, A Noble, ...
ACS Chemical Biology 16 (11), 2387-2400, 2021
42021
Chemical Bioconjugation of Proteins in an Undergraduate Lab: One-Pot Oxidation and Derivatization of the N-Terminus
NDJ Yates, RL Brabham, RJ Spears, T Keenan, PA Helliwell, DS Pugh, ...
Journal of Chemical Education 96 (6), 1245-1249, 2019
32019
Catalyst-free site-selective cross-aldol bioconjugations
NDJ Yates, S Akkad, A Noble, T Keenan, NE Hatton, N Signoret, ...
Green Chemistry 24 (20), 8046-8053, 2022
22022
Characterization of the Streptomyces coelicolor glycoproteome reveals glycoproteins important for cell wall biogenesis. mBio 10: e01092-19
T Keenan, A Dowle, R Bates, MCM Smith
22019
The Retaining Pse5Ac7Ac Pseudaminyltransferase KpsS1 Defines a Previously Unreported glycosyltransferase family (GT118)
AJ Walklett, EKP Flack, HS Chidwick, NE Hatton, T Keenan, D Budhadev, ...
Angewandte Chemie, e202318523, 2024
12024
The retaining Pse5Ac7Ac pseudaminyltransferase KpsS1 defines a new glycosyltransferase family (GTXXX)
A Walklett, E Flack, H Chidwick, N Hatton, T Keenan, D Budhadev, ...
12023
A ‘glyco-fluorine’code revealing differential recognition by glycan binding partners
K Hollingsworth, A Di Maio, SJ Richards, JB Vendeville, DE Wheatley, ...
12023
SUPPLEMENTARY INFORMATION: In the
G Beard
RIN 7, 25-99, 2005
12005
Bioconjugation of polypeptides
MA Fascione, RJ Spears, R Brabham, D Budhadev, T Keenan
US Patent 11,897,917, 2024
2024
Cross aldol OPAL bioconjugation outcompetes intramolecular hemiaminal cyclisation of proline adjacent N-terminal α-oxo aldehydes at acidic pH
A Tufail, S Akkad, NE Hatton, NDJ Yates, RJ Spears, T Keenan, A Parkin, ...
RSC advances 14 (6), 3723-3729, 2024
2024
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