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Sachitanand M Mali
Sachitanand M Mali
Director of Chemistry
Verified email at lilly.com
Title
Cited by
Cited by
Year
Ubiquitin signaling: chemistry comes to the rescue
SM Mali, SK Singh, E Eid, A Brik
Journal of the American Chemical Society 139 (14), 4971-4986, 2017
892017
Convergent versus sequential protein synthesis: the case of ubiquitinated and glycosylated H2B
M Seenaiah, M Jbara, SM Mali, A Brik
Angewandte Chemie 127 (42), 12551-12555, 2015
872015
Thioacids mediated selective and mild N-acylation of amines
SM Mali, RD Bhaisare, HN Gopi
The Journal of organic chemistry 78 (11), 5550-5555, 2013
792013
Total chemical synthesis of SUMO-2-Lys63-linked diubiquitin hybrid chains assisted by removable solubilizing tags
S Bondalapati, E Eid, SM Mali, C Wolberger, A Brik
Chemical science 8 (5), 4027-4034, 2017
702017
The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag
I Sahu, SM Mali, P Sulkshane, C Xu, A Rozenberg, R Morag, MP Sahoo, ...
Nature communications 12 (1), 6173, 2021
692021
De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains
M Nawatha, JM Rogers, SM Bonn, I Livneh, B Lemma, SM Mali, ...
Nature chemistry 11 (7), 644-652, 2019
672019
Synthetic uncleavable ubiquitinated proteins dissect proteasome deubiquitination and degradation, and highlight distinctive fate of tetraubiquitin
SK Singh, I Sahu, SM Mali, HP Hemantha, O Kleifeld, MH Glickman, ...
Journal of the American Chemical Society 138 (49), 16004-16015, 2016
612016
Copper (II) mediated facile and ultra fast peptide synthesis in methanol
SM Mali, SV Jadhav, HN Gopi
Chemical communications 48 (56), 7085-7087, 2012
562012
Protein ubiquitination via dehydroalanine: development and insights into the diastereoselective 1, 4-addition step
R Meledin, SM Mali, SK Singh, A Brik
Organic & biomolecular chemistry 14 (21), 4817-4823, 2016
512016
Diverse fate of ubiquitin chain moieties: The proximal is degraded with the target, and the distal protects the proximal from removal and recycles
H Sun, SM Mali, SK Singh, R Meledin, A Brik, YT Kwon, ...
Proceedings of the National Academy of Sciences 116 (16), 7805-7812, 2019
492019
Activity‐Based Probes Developed by Applying a Sequential Dehydroalanine Formation Strategy to Expressed Proteins Reveal a Potential α‐Globin‐Modulating Deubiquitinase
R Meledin, SM Mali, O Kleifeld, A Brik
Angewandte Chemie 130 (20), 5747-5751, 2018
452018
Thioacetic Acid/NaSH-Mediated Synthesis of N-Protected Amino Thioacids and Their Utility in Peptide Synthesis
SM Mali, HN Gopi
The Journal of Organic Chemistry 79 (6), 2377-2383, 2014
402014
Synthesis of α, β-unsaturated γ-amino esters with unprecedented high (E)-stereoselectivity and their conformational analysis in peptides
SM Mali, A Bandyopadhyay, SV Jadhav, MG Kumar, HN Gopi
Organic & Biomolecular Chemistry 9 (19), 6566-6574, 2011
382011
Tin (II) chloride assisted synthesis of N-protected γ-amino β-keto esters through semipinacol rearrangement
A Bandyopadhyay, N Agrawal, SM Mali, SV Jadhav, HN Gopi
Organic & Biomolecular Chemistry 8 (21), 4855-4860, 2010
282010
Blocking SHH/Patched interaction triggers tumor growth inhibition through Patched-induced apoptosis
PA Bissey, P Mathot, C Guix, M Jasmin, I Goddard, C Costechareyre, ...
Cancer research 80 (10), 1970-1980, 2020
232020
HBTU mediated 1-hydroxybenzotriazole (HOBt) conjugate addition: synthesis and stereochemical analysis of β-benzotriazole N-oxide substituted γ-amino acids and hybrid peptides
SM Mali, MG Kumar, MM Katariya, HN Gopi
Organic & Biomolecular Chemistry 12 (42), 8462-8472, 2014
222014
Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors
SS Chavali, SM Mali, JL Jenkins, R Fasan, JE Wedekind
Journal of Biological Chemistry 295 (49), 16470-16486, 2020
212020
Total chemical synthesis of ester-linked ubiquitinated proteins unravels their behavior with deubiquitinases
H Sun, R Meledin, SM Mali, A Brik
Chemical Science 9 (6), 1661-1665, 2018
212018
Synthesis and structural investigations of functionalizable hybrid β-hairpin
A Bandyopadhyay, SM Mali, P Lunawat, KMP Raja, HN Gopi
Organic Letters 13 (17), 4482-4485, 2011
202011
A facile synthesis and crystallographic analysis of N-protected β-amino alcohols and short peptaibols
SV Jadhav, A Bandyopadhyay, SN Benke, SM Mali, HN Gopi
Organic & biomolecular chemistry 9 (11), 4182-4187, 2011
172011
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