Laura Spagnolo
Laura Spagnolo
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Structure and mechanism of the CMR complex for CRISPR-mediated antiviral immunity
J Zhang, C Rouillon, M Kerou, J Reeks, K Brugger, S Graham, J Reimann, ...
Molecular cell 45 (3), 303-313, 2012
Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair
L Spagnolo, A Rivera-Calzada, LH Pearl, O Llorca
Molecular cell 22 (4), 511-519, 2006
Structure of the CRISPR interference complex CSM reveals key similarities with cascade
C Rouillon, M Zhou, J Zhang, A Politis, V Beilsten-Edmands, G Cannone, ...
Molecular cell 52 (1), 124-134, 2013
Structural model of full‐length human Ku70–Ku80 heterodimer and its recognition of DNA and DNA‐PKcs
A Rivera‐Calzada, L Spagnolo, LH Pearl, O Llorca
EMBO reports 8 (1), 56-62, 2007
Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs)
A Rivera-Calzada, JP Maman, L Spagnolo, LH Pearl, O Llorca
Structure 13 (2), 243-255, 2005
Conformational strain in the hydrophobic core and its implications for protein folding and design
S Ventura, M Cristina Vega, E Lacroix, I Angrand, L Spagnolo, L Serrano
Nature structural biology 9 (6), 485-493, 2002
Visualization of a DNA-PK/PARP1 complex
L Spagnolo, J Barbeau, NJ Curtin, EP Morris, LH Pearl
Nucleic acids research 40 (9), 4168-4177, 2012
Unique features of the sodC-encoded superoxide dismutase from Mycobacterium tuberculosis, a fully functional copper-containing enzyme lacking zinc in the active site
L Spagnolo, I Törö, M D'orazio, P O'Neill, JZ Pedersen, O Carugo, ...
Journal of Biological Chemistry 279 (32), 33447-33455, 2004
Cyclic nucleotide-induced helical structure activates a TIR immune effector
G Hogrel, A Guild, S Graham, H Rickman, S Grüschow, Q Bertrand, ...
Nature 608 (7924), 808-812, 2022
PARP power: a structural perspective on PARP1, PARP2, and PARP3 in DNA damage repair and nucleosome remodelling
L van Beek, É McClay, S Patel, M Schimpl, L Spagnolo, ...
International journal of molecular sciences 22 (10), 5112, 2021
Photobacterium profundum under pressure: a MS-based label-free quantitative proteomics study
T Le Bihan, J Rayner, MM Roy, L Spagnolo
PLoS One 8 (5), e60897, 2013
Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA
ML Rennie, K Lemonidis, C Arkinson, VK Chaugule, M Clarke, J Streetley, ...
EMBO reports 21 (7), e50133, 2020
Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies
EP Morris, A Rivera-Calzada, PCA da Fonseca, O Llorca, LH Pearl, ...
Nucleic acids research 39 (13), 5757-5767, 2011
The architecture of an Okazaki fragment-processing holoenzyme from the archaeon Sulfolobus solfataricus
G Cannone, Y Xu, TR Beattie, SD Bell, L Spagnolo
Biochemical Journal, 2015
Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations
DS Froese, F Forouhar, TH Tran, M Vollmar, YS Kim, S Lew, H Neely, ...
Structure 21 (7), 1182-1192, 2013
Folding specificity induced by loop stiffness
L Spagnolo, S Ventura, L Serrano
Protein science 12 (7), 1473-1482, 2003
A multipronged approach to understanding the form and function of hStaufen protein
S Visentin, G Cannone, J Doutch, G Harris, ML Gleghorn, L Clifton, ...
RNA 26 (3), 265-277, 2020
Structure of an octameric form of the minichromosome maintenance protein from the archaeon Pyrococcus abyssi
G Cannone, S Visentin, A Palud, G Henneke, L Spagnolo
Scientific Reports 7 (1), 42019, 2017
Electron microscopy studies of Type III CRISPR machines in Sulfolobus solfataricus
G Cannone, M Webber-Birungi, L Spagnolo
Biochemical Society Transactions 41 (6), 1427-1430, 2013
Author Correction: Cyclic nucleotide-induced helical structure activates a TIR immune effector (Nature,(2022), 608, 7924,(808-812), 10.1038/s41586-022-05070-9)
G Hogrel, A Guild, S Graham, H Rickman, S Grüschow, Q Bertrand, ...
Nature 614 (7946), E15, 2023
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