| Structure of the human κ-opioid receptor in complex with JDTic H Wu, D Wacker, M Mileni, V Katritch, GW Han, E Vardy, W Liu, ... Nature 485 (7398), 327-332, 2012 | 1077 | 2012 |
| Designer drugs: a medicinal chemistry perspective FI Carroll, AH Lewin, SW Mascarella, HH Seltzman, PA Reddy Annals of the New York Academy of Sciences 1248 (1), 18-38, 2012 | 187 | 2012 |
| Identification of the first trans-(3 R, 4 R)-dimethyl-4-(3-hydroxyphenyl) piperidine derivative to possess highly potent and selective opioid κ receptor antagonist activity JB Thomas, RN Atkinson, RB Rothman, SE Fix, SW Mascarella, ... Journal of medicinal chemistry 44 (17), 2687-2690, 2001 | 134 | 2001 |
| Structure− activity analysis of anandamide analogs: relationship to a cannabinoid pharmacophore BF Thomas, IB Adams, SW Mascarella, BR Martin, RK Razdan Journal of medicinal chemistry 39 (2), 471-479, 1996 | 133 | 1996 |
| Kappa opioid receptor ligands FI Carroll, JB Thomas, SW Mascarella US Patent 6,559,159, 2003 | 129* | 2003 |
| Synthesis, Ligand Binding, and QSAR (CoMFA and Classical) Study of 3. beta.-(3'-Substituted phenyl)-, 3. beta.-(4'-Substituted phenyl)-, and 3. beta.-(3', 4'-Disubstituted … FI Carroll, SW Mascarella, MA Kuzemko, Y Gao, P Abraham, AH Lewin, ... Journal of medicinal chemistry 37 (18), 2865-2873, 1994 | 128 | 1994 |
| A comparison of (−)-deoxybenzomorphans devoid of opiate activity with their dextrorotatory phenolic counterparts suggests role of σ2 receptors in motor function JM Walker, WD Bowen, SL Patrick, WE Williams, SW Mascarella, X Bai, ... European journal of pharmacology 231 (1), 61-68, 1993 | 104 | 1993 |
| Intramolecular photocycloaddition-cyclobutane fragmentation: total synthesis of (.+-.)-silphinene MT Crimmins, SW Mascarella Journal Of The American Chemical Society 108 (12), 3435-3438, 1986 | 97* | 1986 |
| Identification of (3 R)-7-Hydroxy-N-((1 S)-1-{[(3 R, 4 R)-4-(3-hydroxyphenyl)-3, 4-dimethyl-1-piperidinyl] methyl}-2-methylpropyl)-1, 2, 3, 4-tetrahydro-3 … JB Thomas, RN Atkinson, NA Vinson, JL Catanzaro, CL Perretta, SE Fix, ... Journal of medicinal chemistry 46 (14), 3127-3137, 2003 | 94 | 2003 |
| Emergence and properties of spice and bath salts: a medicinal chemistry perspective AH Lewin, HH Seltzman, FI Carroll, SW Mascarella, PA Reddy Life sciences 97 (1), 9-19, 2014 | 88 | 2014 |
| Bupropion and bupropion analogs as treatments for CNS disorders FI Carroll, BE Blough, SW Mascarella, HA Navarro, RJ Lukas, MI Damaj Advances in Pharmacology 69, 177-216, 2014 | 87 | 2014 |
| Enantiomeric N-substituted N-normetazocines: a comparative study of affinities at. sigma., PCP, and. mu. opioid receptors FI Carroll, P Abraham, K Parham, X Bai, X Zhang, GA Brine, ... Journal of medicinal chemistry 35 (15), 2812-2818, 1992 | 86 | 1992 |
| Identification of an opioid κ receptor subtype-selective N-substituent for (+)-(3 R, 4 R)-dimethyl-4-(3-hydroxyphenyl) piperidine JB Thomas, MJ Fall, JB Cooper, RB Rothman, SW Mascarella, H Xu, ... Journal of medicinal chemistry 41 (26), 5188-5197, 1998 | 78 | 1998 |
| Synthesis, Ligand Binding, and Quantitative Structure− Activity Relationship Study of 3β-(4 ‘-Substituted phenyl)-2β-heterocyclic Tropanes: Evidence for an Electrostatic … P Kotian, SW Mascarella, P Abraham, AH Lewin, JW Boja, MJ Kuhar, ... Journal of medicinal chemistry 39 (14), 2753-2763, 1996 | 76 | 1996 |
| Dopamine-transporter uptake blockers: structure-activity relationships FI Carroll, AH Lewin, SW Mascarella Neurotransmitter Transporters: Structure, Function, and Regulation, 381-432, 2002 | 71 | 2002 |
| Investigation of the N-Substituent Conformation Governing Potency and μ Receptor Subtype-Selectivity in (+)-(3 R, 4 R)-Dimethyl-4-(3-hydroxyphenyl)-piperidine Opioid Antagonists JB Thomas, SW Mascarella, RB Rothman, JS Partilla, H Xu, ... Journal of medicinal chemistry 41 (11), 1980-1990, 1998 | 66 | 1998 |
| Hydrolytic instability of the important orexin 1 receptor antagonist SB-334867: possible confounding effects on in vivo and in vitro studies CJ McElhinny Jr, AH Lewin, SW Mascarella, S Runyon, L Brieaddy, ... Bioorganic & medicinal chemistry letters 22 (21), 6661-6664, 2012 | 64 | 2012 |
| Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation RJ Lukas, AZ Muresan, MI Damaj, BE Blough, X Huang, HA Navarro, ... Journal of medicinal chemistry 53 (12), 4731-4748, 2010 | 62 | 2010 |
| Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation FI Carroll, BE Blough, SW Mascarella, HA Navarro, JB Eaton, RJ Lukas, ... Journal of medicinal chemistry 53 (5), 2204-2214, 2010 | 61 | 2010 |
| Synthesis and nicotinic acetylcholine receptor binding properties of bridged and fused ring analogues of epibatidine FI Carroll, TP Robinson, LE Brieaddy, RN Atkinson, SW Mascarella, ... Journal of medicinal chemistry 50 (25), 6383-6391, 2007 | 58 | 2007 |
