Pietro Sormanni
Pietro Sormanni
Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge
Verified email at cam.ac.uk
TitleCited byYear
The CamSol method of rational design of protein mutants with enhanced solubility
P Sormanni, FA Aprile, M Vendruscolo
Journal of molecular biology 427 (2), 478-490, 2015
1152015
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, ...
Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017
1012017
MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins
D Piovesan, F Tabaro, L Paladin, M Necci, I Mičetić, C Camilloni, N Davey, ...
Nucleic acids research 46 (D1), D471-D476, 2018
742018
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins
P Sormanni, FA Aprile, M Vendruscolo
Proceedings of the National Academy of Sciences 112 (32), 9902-9907, 2015
632015
A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer’s disease
R Freer, P Sormanni, G Vecchi, P Ciryam, CM Dobson, M Vendruscolo
Science advances 2 (8), e1600947, 2016
542016
The s2D method: simultaneous sequence-based prediction of the statistical populations of ordered and disordered regions in proteins
P Sormanni, C Camilloni, P Fariselli, M Vendruscolo
Journal of molecular biology 427 (4), 982-996, 2015
542015
Simultaneous quantification of protein order and disorder
P Sormanni, D Piovesan, GT Heller, M Bonomi, P Kukic, C Camilloni, ...
Nature chemical biology 13 (4), 339-342, 2017
532017
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, ...
Science advances 3 (6), e1700488, 2017
462017
Targeting disordered proteins with small molecules using entropy
GT Heller, P Sormanni, M Vendruscolo
Trends in biochemical sciences 40 (9), 491-496, 2015
402015
Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability
C Camilloni, BM Sala, P Sormanni, R Porcari, A Corazza, M De Rosa, ...
Scientific reports 6 (1), 1-11, 2016
382016
Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein
S Gianni, C Camilloni, R Giri, A Toto, D Bonetti, A Morrone, P Sormanni, ...
Proceedings of the National Academy of Sciences 111 (39), 14141-14146, 2014
372014
Rapid and accurate in silico solubility screening of a monoclonal antibody library
P Sormanni, L Amery, S Ekizoglou, M Vendruscolo, B Popovic
Scientific reports 7 (1), 1-9, 2017
342017
Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery
M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, ...
Journal of neuroscience methods 306, 57-67, 2018
202018
Oxetane Grafts Installed Site‐Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo
N Martínez‐Sáez, S Sun, D Oldrini, P Sormanni, O Boutureira, F Carboni, ...
Angewandte Chemie International Edition 56 (47), 14963-14967, 2017
182017
Parapred: antibody paratope prediction using convolutional and recurrent neural networks
E Liberis, P Veličković, P Sormanni, M Vendruscolo, P Liň
Bioinformatics 34 (17), 2944-2950, 2018
172018
A rational design strategy for the selective activity enhancement of a molecular chaperone toward a target substrate
FA Aprile, P Sormanni, M Vendruscolo
Biochemistry 54 (32), 5103-5112, 2015
172015
Fibrillogenic propensity of the GroEL apical domain: a Janus-faced minichaperone
J Chen, H Yagi, P Sormanni, M Vendruscolo, K Makabe, T Nakamura, ...
FEBS letters 586 (8), 1120-1127, 2012
172012
Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity
T Le Marchand, M de Rosa, N Salvi, BM Sala, LB Andreas, ...
Nature communications 9 (1), 1-11, 2018
162018
Developability assessment of engineered monoclonal antibody variants with a complex self-association behavior using complementary analytical and in silico tools
L Shan, N Mody, P Sormani, KL Rosenthal, MM Damschroder, ...
Molecular pharmaceutics 15 (12), 5697-5710, 2018
132018
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, ...
Nature communications 10 (1), 1-11, 2019
122019
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Articles 1–20