| The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 M Komatsu, H Kurokawa, S Waguri, K Taguchi, A Kobayashi, Y Ichimura, ... Nature cell biology 12 (3), 213-223, 2010 | 2320 | 2010 |
| Nrf2–Keap1 defines a physiologically important stress response mechanism H Motohashi, M Yamamoto Trends in molecular medicine 10 (11), 549-557, 2004 | 1916 | 2004 |
| A promoter-level mammalian expression atlas Nature 507 (7493), 462-470, 2014 | 1692 | 2014 |
| Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution K Taguchi, H Motohashi, M Yamamoto Genes to cells 16 (2), 123-140, 2011 | 1643 | 2011 |
| Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription EH Kobayashi, T Suzuki, R Funayama, T Nagashima, M Hayashi, ... Nature communications 7 (1), 1-14, 2016 | 1395 | 2016 |
| Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming Y Mitsuishi, K Taguchi, Y Kawatani, T Shibata, T Nukiwa, H Aburatani, ... Cancer cell 22 (1), 66-79, 2012 | 1347 | 2012 |
| The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis M Yamamoto, TW Kensler, H Motohashi Physiological reviews 98 (3), 1169-1203, 2018 | 1208 | 2018 |
| Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy Y Ichimura, S Waguri, Y Sou, S Kageyama, J Hasegawa, R Ishimura, ... Molecular cell 51 (5), 618-631, 2013 | 1060 | 2013 |
| Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation N Wakabayashi, K Itoh, J Wakabayashi, H Motohashi, S Noda, ... Nature genetics 35 (3), 238-245, 2003 | 986 | 2003 |
| Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling T Ida, T Sawa, H Ihara, Y Tsuchiya, Y Watanabe, Y Kumagai, M Suematsu, ... Proceedings of the National Academy of Sciences 111 (21), 7606-7611, 2014 | 864 | 2014 |
| Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway: identification of novel gene clusters for cell survival MK Kwak, N Wakabayashi, K Itoh, H Motohashi, M Yamamoto, ... Journal of Biological Chemistry 278 (10), 8135-8145, 2003 | 802 | 2003 |
| Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site T Oyake, K Itoh, H Motohashi, N Hayashi, H Hoshino, M Nishizawa, ... Molecular and cellular biology 16 (11), 6083-6095, 1996 | 739 | 1996 |
| Toward clinical application of the Keap1–Nrf2 pathway T Suzuki, H Motohashi, M Yamamoto Trends in pharmacological sciences 34 (6), 340-346, 2013 | 702 | 2013 |
| Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity T Yamamoto, T Suzuki, A Kobayashi, J Wakabayashi, J Maher, ... Molecular and cellular biology 28 (8), 2758-2770, 2008 | 556 | 2008 |
| Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors H Motohashi, T O'Connor, F Katsuoka, JD Engel, M Yamamoto Gene 294 (1-2), 1-12, 2002 | 548 | 2002 |
| Keap1 degradation by autophagy for the maintenance of redox homeostasis K Taguchi, N Fujikawa, M Komatsu, T Ishii, M Unno, T Akaike, ... Proceedings of the National Academy of Sciences 109 (34), 13561-13566, 2012 | 465 | 2012 |
| Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity H Okawa, H Motohashi, A Kobayashi, H Aburatani, TW Kensler, ... Biochemical and biophysical research communications 339 (1), 79-88, 2006 | 452 | 2006 |
| The Keap1–Nrf2 system in cancers: stress response and anabolic metabolism Y Mitsuishi, H Motohashi, M Yamamoto Frontiers in oncology 2, 200, 2012 | 448 | 2012 |
| Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics T Akaike, T Ida, FY Wei, M Nishida, Y Kumagai, MM Alam, H Ihara, ... Nature communications 8 (1), 1177, 2017 | 438 | 2017 |
| Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1–Nrf2 regulatory pathway H Motohashi, F Katsuoka, JD Engel, M Yamamoto Proceedings of the National Academy of Sciences 101 (17), 6379-6384, 2004 | 395 | 2004 |
Masayuki YamamotoTohoku University, ProfessorVerified email at tohoku.ac.jp
