Tuomas Knowles
Tuomas Knowles
Professor of Physical Chemistry and Biophysics, University of Cambridge
Verified email at cam.ac.uk - Homepage
Title
Cited by
Cited by
Year
The amyloid state and its association with protein misfolding diseases
TPJ Knowles, M Vendruscolo, CM Dobson
Nature reviews Molecular cell biology 15 (6), 384-396, 2014
13162014
An analytical solution to the kinetics of breakable filament assembly
TPJ Knowles, CA Waudby, GL Devlin, SIA Cohen, A Aguzzi, ...
Science 326 (5959), 1533-1537, 2009
8022009
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
SIA Cohen, S Linse, LM Luheshi, E Hellstrand, DA White, L Rajah, ...
Proceedings of the National Academy of Sciences 110 (24), 9758-9763, 2013
7522013
Role of intermolecular forces in defining material properties of protein nanofibrils
TP Knowles, AW Fitzpatrick, S Meehan, HR Mott, M Vendruscolo, ...
Science 318 (5858), 1900-1903, 2007
6552007
Nanomechanics of functional and pathological amyloid materials
TPJ Knowles, MJ Buehler
Nature nanotechnology 6 (8), 469-479, 2011
5872011
Characterization of the nanoscale properties of individual amyloid fibrils
JF Smith, TPJ Knowles, CM Dobson, CE MacPhee, ME Welland
Proceedings of the National Academy of Sciences 103 (43), 15806-15811, 2006
5522006
Direct observation of the interconversion of normal and toxic forms of α-synuclein
N Cremades, SIA Cohen, E Deas, AY Abramov, AY Chen, A Orte, ...
Cell 149 (5), 1048-1059, 2012
5362012
Atomic structure and hierarchical assembly of a cross-β amyloid fibril
AWP Fitzpatrick, GT Debelouchina, MJ Bayro, DK Clare, MA Caporini, ...
Proceedings of the National Academy of Sciences 110 (14), 5468-5473, 2013
4012013
Metastability of native proteins and the phenomenon of amyloid formation
AJ Baldwin, TPJ Knowles, GG Tartaglia, AW Fitzpatrick, GL Devlin, ...
Journal of the American Chemical Society 133 (36), 14160-14163, 2011
3222011
On the lag phase in amyloid fibril formation
P Arosio, TPJ Knowles, S Linse
Physical Chemistry Chemical Physics 17 (12), 7606-7618, 2015
3212015
From macroscopic measurements to microscopic mechanisms of protein aggregation
SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
Journal of molecular biology 421 (2-3), 160-171, 2012
3162012
Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation
AK Buell, C Galvagnion, R Gaspar, E Sparr, M Vendruscolo, TPJ Knowles, ...
Proceedings of the National Academy of Sciences 111 (21), 7671-7676, 2014
3092014
Nanostructured films from hierarchical self-assembly of amyloidogenic proteins
TPJ Knowles, TW Oppenheim, AK Buell, DY Chirgadze, ME Welland
Nature nanotechnology 5 (3), 204, 2010
2972010
Stabilization of neurotoxic Alzheimer amyloid-β oligomers by protein engineering
A Sandberg, LM Luheshi, S Söllvander, TP de Barros, B Macao, ...
Proceedings of the National Academy of Sciences 107 (35), 15595-15600, 2010
2892010
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
C Galvagnion, AK Buell, G Meisl, TCT Michaels, M Vendruscolo, ...
Nature chemical biology 11 (3), 229, 2015
2862015
Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides
G Meisl, X Yang, E Hellstrand, B Frohm, JB Kirkegaard, SIA Cohen, ...
Proceedings of the National Academy of Sciences 111 (26), 9384-9389, 2014
2622014
Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments
SIA Cohen, M Vendruscolo, ME Welland, CM Dobson, EM Terentjev, ...
The Journal of chemical physics 135 (6), 08B615, 2011
2422011
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, ...
Proceedings of the National Academy of Sciences 112 (16), E1994-E2003, 2015
2262015
A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers
SIA Cohen, P Arosio, J Presto, FR Kurudenkandy, H Biverstĺl, L Dolfe, ...
Nature structural & molecular biology 22 (3), 207, 2015
2252015
Molecular mechanisms of protein aggregation from global fitting of kinetic models
G Meisl, JB Kirkegaard, P Arosio, TCT Michaels, M Vendruscolo, ...
Nature protocols 11 (2), 252, 2016
2142016
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