The structures of type I polyketide synthases AT Keatinge-Clay Natural product reports 29 (10), 1050-1073, 2012 | 383 | 2012 |
A tylosin ketoreductase reveals how chirality is determined in polyketides AT Keatinge-Clay Chemistry & biology 14 (8), 898-908, 2007 | 361 | 2007 |
The structure of a ketoreductase determines the organization of the β-carbon processing enzymes of modular polyketide synthases AT Keatinge-Clay, RM Stroud Structure 14 (4), 737-748, 2006 | 271 | 2006 |
Crystal structure of the erythromycin polyketide synthase dehydratase A Keatinge-Clay Journal of molecular biology 384 (4), 941-953, 2008 | 241 | 2008 |
High-resolution macromolecular NMR spectroscopy inside living cells Z Serber, AT Keatinge-Clay, R Ledwidge, AE Kelly, SM Miller, V Dötsch Journal of the American Chemical Society 123 (10), 2446-2447, 2001 | 238 | 2001 |
An antibiotic factory caught in action AT Keatinge-Clay, DA Maltby, KF Medzihradszky, C Khosla, RM Stroud Nature structural & molecular biology 11 (9), 888-893, 2004 | 217 | 2004 |
Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA: ACP transacylase AT Keatinge-Clay, AA Shelat, DF Savage, SC Tsai, LJW Miercke, ... Structure 11 (2), 147-154, 2003 | 177 | 2003 |
Enzymatic extender unit generation for in vitro polyketide synthase reactions: structural and func-tional showcasing of Streptomyces coelicolor MatB AJ Hughes, A Keatinge-Clay Chemistry & biology 18 (2), 165-176, 2011 | 150 | 2011 |
Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase J Zheng, CA Taylor, SK Piasecki, AT Keatinge-Clay Structure 18 (8), 913-922, 2010 | 124 | 2010 |
The structure of SpnF, a standalone enzyme that catalyzes [4+ 2] cycloaddition CD Fage, EA Isiorho, Y Liu, DT Wagner, H Liu, AT Keatinge-Clay Nature chemical biology 11 (4), 256-258, 2015 | 114 | 2015 |
Divergence of multimodular polyketide synthases revealed by a didomain structure J Zheng, DC Gay, B Demeler, MA White, AT Keatinge-Clay Nature chemical biology 8 (7), 615-621, 2012 | 106 | 2012 |
Stereocontrol within polyketide assembly lines AT Keatinge-Clay Natural product reports 33 (2), 141-149, 2016 | 104 | 2016 |
Generalized bacterial genome editing using mobile group II introns and Cre‐lox PJ Enyeart, SM Chirieleison, MN Dao, J Perutka, EM Quandt, J Yao, ... Molecular systems biology 9 (1), 685, 2013 | 102 | 2013 |
Crystal structure of the priming β-ketosynthase from the R1128 polyketide biosynthetic pathway H Pan, S Tsai, ES Meadows, LJW Miercke, AT Keatinge-Clay, J O'Connell, ... Structure 10 (11), 1559-1568, 2002 | 102 | 2002 |
Employing modular polyketide synthase ketoreductases as biocatalysts in the preparative chemoenzymatic syntheses of diketide chiral building blocks SK Piasecki, CA Taylor, JF Detelich, J Liu, J Zheng, A Komsoukaniants, ... Chemistry & biology 18 (10), 1331-1340, 2011 | 97 | 2011 |
Stereospecificity of the dehydratase domain of the erythromycin polyketide synthase CR Valenzano, YO You, A Garg, A Keatinge-Clay, C Khosla, DE Cane Journal of the American Chemical Society 132 (42), 14697-14699, 2010 | 95 | 2010 |
A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase DC Gay, G Gay, AJ Axelrod, M Jenner, C Kohlhaas, A Kampa, NJ Oldham, ... Structure 22 (3), 444-451, 2014 | 83 | 2014 |
The uncommon enzymology of cis-acyltransferase assembly lines AT Keatinge-Clay Chemical reviews 117 (8), 5334-5366, 2017 | 80 | 2017 |
Polyketide synthase modules redefined AT Keatinge-Clay Angewandte Chemie (International ed. in English) 56 (17), 4658, 2017 | 77 | 2017 |
Structure and stereospecificity of the dehydratase domain from the terminal module of the rifamycin polyketide synthase D Gay, YO You, A Keatinge-Clay, DE Cane Biochemistry 52 (49), 8916-8928, 2013 | 72 | 2013 |