| Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease J Yao, RW Irwin, L Zhao, J Nilsen, RT Hamilton, RD Brinton Proceedings of the National Academy of Sciences 106 (34), 14670-14675, 2009 | 997 | 2009 |
| Progesterone and estrogen regulate oxidative metabolism in brain mitochondria RW Irwin, J Yao, RT Hamilton, E Cadenas, RD Brinton, J Nilsen Endocrinology 149 (6), 3167-3175, 2008 | 317 | 2008 |
| Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease JM Wang, C Singh, L Liu, RW Irwin, S Chen, EJ Chung, RF Thompson, ... Proceedings of the National Academy of Sciences 107 (14), 6498-6503, 2010 | 308 | 2010 |
| Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function J Nilsen, S Chen, RW Irwin, S Iwamoto, RD Brinton BMC neuroscience 7, 1-14, 2006 | 225 | 2006 |
| Estradiol in vivo regulation of brain mitochondrial proteome J Nilsen, RW Irwin, TK Gallaher, RD Brinton Journal of Neuroscience 27 (51), 14069-14077, 2007 | 203 | 2007 |
| Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's disease S Chen, JM Wang, RW Irwin, J Yao, L Liu, RD Brinton PloS one 6 (8), e24293, 2011 | 144 | 2011 |
| Ovarian hormone loss induces bioenergetic deficits and mitochondrial β-amyloid J Yao, R Irwin, S Chen, R Hamilton, E Cadenas, RD Brinton Neurobiology of aging 33 (8), 1507-1521, 2012 | 142 | 2012 |
| Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice C Singh, L Liu, JM Wang, RW Irwin, J Yao, S Chen, S Henry, ... Neurobiology of aging 33 (8), 1493-1506, 2012 | 139 | 2012 |
| 1α,25-(OH)2-D3 and Its Synthetic Analogue Decrease Tumor Load in the Apcmin Mouse S Huerta, RW Irwin, D Heber, VLW Go, HP Koeffler, MR Uskokovic, ... Cancer research 62 (3), 741-746, 2002 | 139 | 2002 |
| Regenerative potential of allopregnanolone JM Wang, L Liu, RW Irwin, S Chen, RD Brinton Brain research reviews 57 (2), 398-409, 2008 | 121 | 2008 |
| Activation of estrogen receptor α increases and estrogen receptor β decreases apolipoprotein E expression in hippocampus in vitro and in vivo JM Wang, RW Irwin, RD Brinton Proceedings of the National Academy of Sciences 103 (45), 16983-16988, 2006 | 118 | 2006 |
| Allopregnanolone as regenerative therapeutic for Alzheimer's disease: translational development and clinical promise RW Irwin, RD Brinton Progress in neurobiology 113, 40-55, 2014 | 107 | 2014 |
| Selective oestrogen receptor modulators differentially potentiate brain mitochondrial function RW Irwin, J Yao, J To, RT Hamilton, E Cadenas, RD Brinton Journal of neuroendocrinology 24 (1), 236-248, 2012 | 93 | 2012 |
| Frontiers in therapeutic development of allopregnanolone for Alzheimer’s disease and other neurological disorders RW Irwin, CM Solinsky, RD Brinton Frontiers in cellular neuroscience 8, 203, 2014 | 74 | 2014 |
| Medroxyprogesterone acetate antagonizes estrogen up-regulation of brain mitochondrial function RW Irwin, J Yao, SS Ahmed, RT Hamilton, E Cadenas, RD Brinton Endocrinology 152 (2), 556-567, 2011 | 66 | 2011 |
| Regeneration in a degenerating brain: potential of allopregnanolone as a neuroregenerative agent JM Wang, RW Irwin, L Liu, S Chen, RD Brinton Current Alzheimer Research 4 (5), 510-517, 2007 | 57 | 2007 |
| Neuroregenerative mechanisms of allopregnanolone in Alzheimer’s disease RW Irwin, JM Wang, S Chen, RD Brinton Frontiers in endocrinology 2, 117, 2012 | 56 | 2012 |
| Open-label allopregnanolone treatment of men with fragile X-associated tremor/ataxia syndrome JY Wang, AM Trivedi, NR Carrillo, J Yang, A Schneider, C Giulivi, ... Neurotherapeutics 14 (4), 1073-1083, 2017 | 53 | 2017 |
| PC-SPES Inhibits Colon Cancer Growth in Vitro and in Vivo S Huerta, JR Arteaga, RW Irwin, T Ikezoe, D Heber, HP Koeffler Cancer research 62 (18), 5204-5209, 2002 | 50 | 2002 |
| Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for Alzheimer’s disease RW Irwin, CM Solinsky, CM Loya, FG Salituro, KE Rodgers, G Bauer, ... PloS one 10 (6), e0128313, 2015 | 49 | 2015 |
