neil carragher
neil carragher
Professor of Drug Discovery, University of Edinburgh
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Cited by
Cited by
The role of focal-adhesion kinase in cancer—a new therapeutic opportunity
GW McLean, NO Carragher, E Avizienyte, J Evans, VG Brunton, ...
Nature Reviews Cancer 5 (7), 505-515, 2005
Resolving the fibrotic niche of human liver cirrhosis at single-cell level
P Ramachandran, R Dobie, JR Wilson-Kanamori, EF Dora, ...
Nature 575 (7783), 512-518, 2019
The calpain system and cancer
SJ Storr, NO Carragher, MC Frame, T Parr, SG Martin
Nature Reviews Cancer 11 (5), 364-374, 2011
Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion
NO Carragher, MC Frame
Trends in cell biology 14 (5), 241-249, 2004
v-Src's hold over actin and cell adhesions
MC Frame, VJ Fincham, NO Carragher, JA Wyke
Nature Reviews Molecular Cell Biology 3 (4), 233-245, 2002
Screening out irrelevant cell-based models of disease
P Horvath, N Aulner, M Bickle, AM Davies, ED Nery, D Ebner, ...
Nature reviews Drug discovery 15 (11), 751-769, 2016
Degraded Collagen Fragments Promote Rapid Disassembly of Smooth Muscle Focal Adhesions That Correlates with Cleavage of Pp125FAK, Paxillin, and Talin
NO Carragher, B Levkau, R Ross, EW Raines
The Journal of cell biology 147 (3), 619-630, 1999
SRC-mediated phosphorylation of focal adhesion kinase couples actin and adhesion dynamics to survival signaling
MA Westhoff, B Serrels, VJ Fincham, MC Frame, NO Carragher
Molecular and cellular biology 24 (18), 8113-8133, 2004
A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src
NO Carragher, MA Westhoff, VJ Fincham, MD Schaller, MC Frame
Current biology 13 (16), 1442-1450, 2003
Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach
JT Weiss, JC Dawson, KG Macleod, W Rybski, C Fraser, ...
Nature communications 5 (1), 1-9, 2014
Calpain inhibition: a therapeutic strategy targeting multiple disease states
NO Carragher
Current pharmaceutical design 12 (5), 615-638, 2006
Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530
TP Green, M Fennell, R Whittaker, J Curwen, V Jacobs, J Allen, A Logie, ...
Molecular oncology 3 (3), 248-261, 2009
Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis
N Ferri, NO Carragher, EW Raines
The American journal of pathology 164 (5), 1575-1585, 2004
Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma
MR Girotti, F Lopes, N Preece, D Niculescu-Duvaz, A Zambon, L Davies, ...
Cancer cell 27 (1), 85-96, 2015
Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function
NO Carragher, SM Walker, LA Scott Carragher, F Harris, TK Sawyer, ...
Oncogene 25 (42), 5726-5740, 2006
Cleavage of focal adhesion kinase by different proteases during Src-regulated transformation and apoptosis: distinct roles for calpain and caspases
NO Carragher, VJ Fincham, D Riley, MC Frame
Journal of Biological Chemistry 276 (6), 4270-4275, 2001
Calpain: a role in cell transformation and migration
NO Carragher, MC Frame
The international journal of biochemistry & cell biology 34 (12), 1539-1543, 2002
Development and bioorthogonal activation of palladium-labile prodrugs of gemcitabine
JT Weiss, JC Dawson, C Fraser, W Rybski, C Torres-Sánchez, M Bradley, ...
Journal of medicinal chemistry 57 (12), 5395-5404, 2014
FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis
BZ Qian, H Zhang, J Li, T He, EJ Yeo, DYH Soong, NO Carragher, ...
Journal of Experimental Medicine 212 (9), 1433-1448, 2015
Realizing the promise of reverse phase protein arrays for clinical, translational, and basic research: a workshop report: the RPPA (Reverse Phase Protein Array) society
R Akbani, KF Becker, N Carragher, T Goldstein, L De Koning, U Korf, ...
Molecular & cellular proteomics 13 (7), 1625-1643, 2014
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