Chromosomal deletions on 16p11.2 encompassing SH2B1 are associated with accelerated metabolic disease R Hanssen, C Auwerx, M Jõeloo, MC Sadler, EBR Team, E Henning, ... Cell Reports Medicine 4 (8), 101155, 2023 | 6 | 2023 |
A rare human variant that disrupts GPR10 signalling causes weight gain in mice F Talbot, CH Feetham, J Mokrosiński, K Lawler, JM Keogh, E Henning, ... Nature Communications 14 (1), 1450, 2023 | | 2023 |
Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior Y He, B Brouwers, H Liu, H Liu, K Lawler, E Mendes de Oliveira, DK Lee, ... Nature Medicine 28 (12), 2537-2546, 2022 | 11 | 2022 |
MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis MP LaPierre, K Lawler, S Godbersen, IS Farooqi, M Stoffel Nature Communications 13 (1), 5733, 2022 | 8 | 2022 |
Osimertinib and anti-HER3 combination therapy engages immune dependent tumor toxicity via STING activation in trans JM Vicencio, R Evans, R Green, Z An, J Deng, C Treacy, R Mustapha, ... Cell Death & Disease 13 (3), 1-14, 2022 | 12 | 2022 |
Predicting novel candidate human obesity genes and their site of action by systematic functional screening in Drosophila N Agrawal, K Lawler, CM Davidson, JM Keogh, R Legg, INTERVAL, ... PLoS Biology 19 (11), e3001255, 2021 | 11 | 2021 |
Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity I Cimino, D Rimmington, YC Tung, K Lawler, P Larraufie, RG Kay, S Virtue, ... Scientific Reports 11 (1), 1-15, 2021 | 7 | 2021 |
HER2-HER3 heterodimer quantification by FRET-FLIM and patient subclass analysis of the COIN colorectal trial PR Barber, G Weitsman, K Lawler, JE Barrett, M Rowley, ... JNCI: Journal of the National Cancer Institute 112 (9), 944-954, 2020 | 12 | 2020 |
Leptin-mediated changes in the human metabolome K Lawler, I Huang-Doran, T Sonoyama, TH Collet, JM Keogh, E Henning, ... JCEM, https://doi.org/10.1210/clinem/dgaa251, 2020 | 25 | 2020 |
Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer R Evans, F Flores-Borja, S Nassiri, E Miranda, K Lawler, A Grigoriadis, ... Cell Reports 27 (7), 1967-1978. e4, 2019 | 41 | 2019 |
Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis Y Yang, AA van der Klaauw, L Zhu, TM Cacciottolo, Y He, LKJ Stadler, ... Nature Communications 10 (1), 1718, 2019 | 53 | 2019 |
ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation J Monypenny, H Milewicz, F Flores-Borja, G Weitsman, A Cheung, ... Cell Reports 24 (3), 630-641, 2018 | 118 | 2018 |
A transcriptomic signature of the hypothalamic response to fasting and BDNF deficiency in Prader-Willi syndrome E Bochukova, K Lawler, S Croizier, JM Keogh, N Patel, G Strohbehn, ... Cell Reports 22 (13), 3401-3408, 2018 | 84 | 2018 |
Mutational landscape of lymph node metastasis exomes in breast cancers Q Guo, K Lawler, C Gillett, T Pai, J Quist, S Nowinski, M Simpson, T Ng, ... European Journal of Surgical Oncology 44 (S30), doi:10.1016/j.ejso.2018.01.550, 2018 | | 2018 |
Gene expression modules in primary breast cancers as risk factors for organotropic patterns of first metastatic spread: a case control study K Lawler, E Papouli, C Naceur-Lombardelli, A Mera, K Ougham, A Tutt, ... Breast Cancer Research 19, 113, 2017 | 8 | 2017 |
Association between hypoxic volume and underlying hypoxia-induced gene expression in oropharyngeal squamous cell carcinoma Y Suh, K Lawler, R Henley-Smith, L Pike, R Leek, S Barrington, EW Odell, ... British Journal of Cancer 116 (8), 1057-1064, 2017 | 22 | 2017 |
RORγt+ Innate Lymphoid Cells Promote Lymph Node Metastasis of Breast Cancers S Irshad, F Flores-Borja, K Lawler, J Monypenny, R Evans, V Male, ... Cancer Research 77 (5), 1083-1096, 2017 | 119 | 2017 |
HER2-HER3 dimer quantification by FLIM-FRET predicts breast cancer metastatic relapse independently of HER2 IHC status G Weitsman, PR Barber, LK Nguyen, K Lawler, G Patel, N Woodman, ... Oncotarget 7 (32), 51012-51026, 2016 | 37 | 2016 |
MicroRNA‐196a promotes an oncogenic effect in head and neck cancer cells by suppressing annexin A1 and enhancing radioresistance YE Suh, N Raulf, J Gäken, K Lawler, TG Urbano, J Bullenkamp, S Gobeil, ... International Journal of Cancer 137 (5), 1021-1034, 2015 | 104 | 2015 |
Use of FLIM histology-based HER2-HER3 heterodimer quantification and a Bayesian latent class proportional hazards model to predict cetuximab response in the COIN and new EPOC … T Ng, G Weitsman, P Barber, K Lawler, M Rowley, G Elshtein, ... ASCO Annual Meeting Proceedings 33 (15_suppl), e14535, 2015 | | 2015 |