Derek Mann
Derek Mann
Professor of Hepatology, Newcastle University
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Chronic inflammation induces telomere dysfunction and accelerates ageing in mice
D Jurk, C Wilson, JF Passos, F Oakley, C Correia-Melo, L Greaves, ...
Nature communications 5 (1), 1-14, 2014
The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis
AM Elsharkawy, F Oakley, DA Mann
Apoptosis 10 (5), 927-939, 2005
Cellular senescence drives age-dependent hepatic steatosis
M Ogrodnik, S Miwa, T Tchkonia, D Tiniakos, CL Wilson, A Lahat, CP Day, ...
Nature communications 8 (1), 1-12, 2017
Nuclear factor‐κB and the hepatic inflammation‐fibrosis‐cancer axis
AM Elsharkawy, DA Mann
Hepatology 46 (2), 590-597, 2007
Clinical evidence for the regression of liver fibrosis
EL Ellis, DA Mann
Journal of hepatology 56 (5), 1171-1180, 2012
Mitochondria are required for pro‐ageing features of the senescent phenotype
C Correia‐Melo, FDM Marques, R Anderson, G Hewitt, R Hewitt, J Cole, ...
The EMBO journal 35 (7), 724-742, 2016
Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats
MC Wright, R Issa, DE Smart, N Trim, GI Murray, JN Primrose, MJP Arthur, ...
Gastroenterology 121 (3), 685-698, 2001
MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis
J Mann, DCK Chu, A Maxwell, F Oakley, NL Zhu, H Tsukamoto, DA Mann
Gastroenterology 138 (2), 705-714. e4, 2010
Inhibition of inhibitor of κB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis
F Oakley, M Meso, JP Iredale, K Green, CJ Marek, X Zhou, MJ May, ...
Gastroenterology 128 (1), 108-120, 2005
Transcriptional regulation of hepatic stellate cell activation
DA Mann, DE Smart
Gut 50 (6), 891-896, 2002
Multigenerational epigenetic adaptation of the hepatic wound-healing response
M Zeybel, T Hardy, YK Wong, JC Mathers, CR Fox, A Gackowska, ...
Nature medicine 18 (9), 1369-1377, 2012
Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis
J Mann, F Oakley, F Akiboye, A Elsharkawy, AW Thorne, DA Mann
Cell Death & Differentiation 14 (2), 275-285, 2007
A molecular rheostat: Co-operative rev binding to stem I of the Rev-response element modulates human immunodeficiency virus type-1 late gene expression
DA Mann, I Mikaélian, RW Zemmel, SM Green, AD Lowe, T Kimura, ...
Journal of molecular biology 241 (2), 193-207, 1994
Neurite outgrowth in response to transfected N-CAM and N-cadherin reveals fundamental differences in neuronal responsiveness to CAMs
P Doherty, LH Rowett, SE Moore, DA Mann, FS Walsh
Neuron 6 (2), 247-258, 1991
Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer
M Malehmir, D Pfister, S Gallage, M Szydlowska, D Inverso, E Kotsiliti, ...
Nature medicine 25 (4), 641-655, 2019
A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis
RG Ruddell, F Oakley, Z Hussain, I Yeung, LJ Bryan-Lluka, GA Ramm, ...
The American journal of pathology 169 (3), 861-876, 2006
Stimulating healthy tissue regeneration by targeting the 5-HT2B receptor in chronic liver disease
MR Ebrahimkhani, F Oakley, LB Murphy, J Mann, A Moles, MJ Perugorria, ...
Nature medicine 17 (12), 1668-1673, 2011
Tissue inhibitors of metalloproteinases, hepatic stellate cells and liver fibrosis
MJP Arthur, DA Mann, JP Iredale
Journal of gastroenterology and hepatology 13 (S1), S33-S38, 1998
Signal transduction via the NF‐κB pathway: a targeted treatment modality for infection, inflammation and repair
S Ali, DA Mann
Cell Biochemistry and Function: Cellular biochemistry and its modulation by …, 2004
Identification of the Nef-associated kinase as p21-activated kinase 2
GH Renkema, A Manninen, DA Mann, M Harris, K Saksela
Current Biology 9 (23), 1407-1411, 1999
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