Darrell J. Irvine
Darrell J. Irvine
Verified email at mit.edu - Homepage
TitleCited byYear
Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles
A Verma, O Uzun, Y Hu, Y Hu, HS Han, N Watson, S Chen, DJ Irvine, ...
Nature materials 7 (7), 588, 2008
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
CM Metallo, PA Gameiro, EL Bell, KR Mattaini, J Yang, K Hiller, ...
Nature 481 (7381), 380, 2012
Direct observation of ligand recognition by T cells
DJ Irvine, MA Purbhoo, M Krogsgaard, MM Davis
Nature 419 (6909), 845, 2002
Bio-inspired, bioengineered and biomimetic drug delivery carriers
JW Yoo, DJ Irvine, DE Discher, S Mitragotri
Nature reviews Drug discovery 10 (7), 521, 2011
T cell killing does not require the formation of a stable mature immunological synapse
MA Purbhoo, DJ Irvine, JB Huppa, MM Davis
Nature immunology 5 (5), 524, 2004
Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus
LY Koo, DJ Irvine, AM Mayes, DA Lauffenburger, LG Griffith
Journal of cell science 115 (7), 1423-1433, 2002
Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses
JJ Moon, H Suh, A Bershteyn, MT Stephan, H Liu, B Huang, M Sohail, ...
Nature materials 10 (3), 243, 2011
Therapeutic cell engineering with surface-conjugated synthetic nanoparticles
MT Stephan, JJ Moon, SH Um, A Bershteyn, DJ Irvine
Nature medicine 16 (9), 1035, 2010
Structure-based programming of lymph-node targeting in molecular vaccines
H Liu, KD Moynihan, Y Zheng, GL Szeto, AV Li, B Huang, DS Van Egeren, ...
Nature 507 (7493), 519, 2014
Synthetic nanoparticles for vaccines and immunotherapy
DJ Irvine, MC Hanson, K Rakhra, T Tokatlian
Chemical reviews 115 (19), 11109-11146, 2015
Engineering nano‐and microparticles to tune immunity
JJ Moon, B Huang, DJ Irvine
Advanced materials 24 (28), 3724-3746, 2012
Engineering synthetic vaccines using cues from natural immunity
DJ Irvine, MA Swartz, GL Szeto
Nature materials 12 (11), 978, 2013
Cytosolic delivery of membrane-impermeable molecules in dendritic cells using pH-responsive core− shell nanoparticles
Y Hu, T Litwin, AR Nagaraja, B Kwong, J Katz, N Watson, DJ Irvine
Nano letters 7 (10), 3056-3064, 2007
CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse
QJ Li, AR Dinner, S Qi, DJ Irvine, JB Huppa, MM Davis, AK Chakraborty
Nature immunology 5 (8), 791, 2004
Nanoscale clustering of RGD peptides at surfaces using comb polymers. 1. Synthesis and characterization of comb thin films
DJ Irvine, AM Mayes, LG Griffith
Biomacromolecules 2 (1), 85-94, 2001
Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction
JJ Moon, H Suh, AV Li, CF Ockenhouse, A Yadava, DJ Irvine
Proceedings of the National Academy of Sciences 109 (4), 1080-1085, 2012
Particulate vaccines: on the quest for optimal delivery and immune response
ML De Temmerman, J Rejman, J Demeester, DJ Irvine, B Gander, ...
Drug discovery today 16 (13-14), 569-582, 2011
A role for the immunological synapse in lineage commitment of CD4 lymphocytes
RA Maldonado, DJ Irvine, R Schreiber, LH Glimcher
Nature 431 (7008), 527, 2004
Surface functionalization of living cells with multilayer patches
AJ Swiston, C Cheng, SH Um, DJ Irvine, RE Cohen, MF Rubner
Nano letters 8 (12), 4446-4453, 2008
Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses
KD Moynihan, CF Opel, GL Szeto, A Tzeng, EF Zhu, JM Engreitz, ...
Nature medicine 22 (12), 1402, 2016
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