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Dinesh Gautam
Dinesh Gautam
Pharmacologist, FDA
Verified email at fda.hhs.gov
Title
Cited by
Cited by
Year
Role of brain insulin receptor in control of body weight and reproduction
JC Bruning, D Gautam, DJ Burks, J Gillette, M Schubert, PC Orban, ...
Science 289 (5487), 2122-2125, 2000
27402000
Role for neuronal insulin resistance in neurodegenerative diseases
M Schubert, D Gautam, D Surjo, K Ueki, S Baudler, D Schubert, T Kondo, ...
Proceedings of the National Academy of Sciences 101 (9), 3100-3105, 2004
7672004
Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
J Wess, RM Eglen, D Gautam
Nature reviews Drug discovery 6 (9), 721-733, 2007
7422007
Muscarinic acetylcholine receptors: novel opportunities for drug development
AC Kruse, BK Kobilka, D Gautam, PM Sexton, A Christopoulos, J Wess
Nature reviews Drug discovery 13 (7), 549-560, 2014
4622014
A chemical-genetic approach to study G protein regulation of β cell function in vivo
JM Guettier, D Gautam, M Scarselli, IR de Azua, JH Li, E Rosemond, X Ma, ...
Proceedings of the National Academy of Sciences 106 (45), 19197-19202, 2009
3932009
A critical role for β cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo
D Gautam, SJ Han, FF Hamdan, J Jeon, B Li, JH Li, Y Cui, D Mears, H Lu, ...
Cell metabolism 3 (6), 449-461, 2006
3452006
Muscarinic Stimulation of Pancreatic Insulin and Glucagon Release Is Abolished in M3 Muscarinic Acetylcholine Receptor–Deficient Mice
A Duttaroy, CL Zimliki, D Gautam, Y Cui, D Mears, J Wess
Diabetes 53 (7), 1714-1720, 2004
2572004
Cholinergic stimulation of salivary secretion studied with M1 and M3 muscarinic receptor single-and double-knockout mice
D Gautam, TS Heard, Y Cui, G Miller, L Bloodworth, J Wess
Molecular pharmacology 66 (2), 260-267, 2004
1842004
Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance
M Röhl, M Pasparakis, S Baudler, J Baumgartl, D Gautam, M Huth, ...
The Journal of clinical investigation 113 (3), 474-481, 2004
1412004
Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency
D Gautam, O Gavrilova, J Jeon, S Pack, W Jou, Y Cui, JH Li, J Wess
Cell metabolism 4 (5), 363-375, 2006
1132006
RGS4 is a negative regulator of insulin release from pancreatic β-cells in vitro and in vivo
I Ruiz de Azua, M Scarselli, E Rosemond, D Gautam, W Jou, O Gavrilova, ...
Proceedings of the National Academy of Sciences 107 (17), 7999-8004, 2010
1092010
Role of the M3 muscarinic acetylcholine receptor in β‐cell function and glucose homeostasis
D Gautam, SJ Han, A Duttaroy, D Mears, FF Hamdan, JH Li, Y Cui, J Jeon, ...
Diabetes, Obesity and Metabolism 9, 158-169, 2007
972007
A Novel Experimental Strategy to Assess the Metabolic Effects of Selective Activation of a Gq-Coupled Receptor in Hepatocytes In Vivo
J Hua Li, S Jain, SM McMillin, Y Cui, D Gautam, W Sakamoto, H Lu, ...
Endocrinology 154 (10), 3539-3551, 2013
732013
Novel insights into the function of β-cell M3 muscarinic acetylcholine receptors: therapeutic implications
IR de Azua, D Gautam, JM Guettier, J Wess
Trends in Endocrinology & Metabolism 22 (2), 74-80, 2011
702011
Distinct muscarinic acetylcholine receptor subtypes contribute to stability and growth, but not compensatory plasticity, of neuromuscular synapses
MC Wright, S Potluri, X Wang, E Dentcheva, D Gautam, A Tessler, J Wess, ...
Journal of Neuroscience 29 (47), 14942-14955, 2009
702009
Muscarinic acetylcholine receptor knockout mice show distinct synaptic plasticity impairments in the visual cortex
N Origlia, N Kuczewski, E Aztiria, D Gautam, J Wess, L Domenici
The Journal of physiology 577 (3), 829-840, 2006
682006
Metabolic Roles of the M3 Muscarinic Acetylcholine Receptor Studied with M3 Receptor Mutant Mice: A Review
D Gautam, J Jeon, JH Li, SJ Han, FF Hamdan, Y Cui, H Lu, C Deng, ...
Journal of Receptors and Signal Transduction 28 (1-2), 93-108, 2008
672008
Cholinergic stimulation of amylase secretion from pancreatic acinar cells studied with muscarinic acetylcholine receptor mutant mice
D Gautam, SJ Han, TS Heard, Y Cui, G Miller, L Bloodworth, J Wess
Journal of Pharmacology and Experimental Therapeutics 313 (3), 995-1002, 2005
662005
Hepatic muscarinic acetylcholine receptors are not critically involved in maintaining glucose homeostasis in mice
JH Li, D Gautam, SJ Han, JM Guettier, Y Cui, H Lu, C Deng, J O'Hare, ...
Diabetes 58 (12), 2776-2787, 2009
602009
Beneficial Metabolic Effects Caused by Persistent Activation of β-Cell M3 Muscarinic Acetylcholine Receptors in Transgenic Mice
D Gautam, IR de Azua, JH Li, JM Guettier, T Heard, Y Cui, H Lu, W Jou, ...
Endocrinology 151 (11), 5185-5194, 2010
552010
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