Joseph Leedale
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Tight control of hypoxia-inducible factor-α transient dynamics is essential for cell survival in hypoxia
J Bagnall, J Leedale, SE Taylor, DG Spiller, MRH White, KJ Sharkey, ...
Journal of Biological Chemistry 289 (9), 5549-5564, 2014
Impact of cell types and culture methods on the functionality of in vitro liver systems–A review of cell systems for hepatotoxicity assessment
JA Kyffin, P Sharma, J Leedale, HE Colley, C Murdoch, P Mistry, ...
Toxicology In Vitro 48, 262-275, 2018
Projecting malaria hazard from climate change in eastern Africa using large ensembles to estimate uncertainty
J Leedale, AM Tompkins, C Caminade, AE Jones, G Nikulin, AP Morse
Geospatial health 11 (1 Supp), 102-114, 2016
Characterisation of a functional rat hepatocyte spheroid model
JA Kyffin, P Sharma, J Leedale, HE Colley, C Murdoch, AL Harding, ...
Toxicology in Vitro 55, 160-172, 2019
Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms
CS Pridgeon, C Schlott, MW Wong, MB Heringa, T Heckel, J Leedale, ...
Archives of toxicology 92, 557-569, 2018
Multiscale modelling of drug transport and metabolism in liver spheroids
JA Leedale, JA Kyffin, AL Harding, HE Colley, C Murdoch, P Sharma, ...
Interface focus 10 (2), 20190041, 2020
Modeling the dynamics of hypoxia inducible factor-1α (HIF-1α) within single cells and 3D cell culture systems
J Leedale, A Herrmann, J Bagnall, A Fercher, D Papkovsky, V Se, ...
Mathematical biosciences 258, 33-43, 2014
Environmental change and Rift Valley fever in eastern Africa: projecting beyond HEALTHY FUTURES
D Taylor, M Hagenlocher, AE Jones, S Kienberger, J Leedale, AP Morse
Geospatial Health 11 (s1), 2016
A dynamic, climate-driven model of Rift Valley fever
J Leedale, AE Jones, C Caminade, AP Morse
Geospatial health 11 (s1), 2016
Modelling changes in glutathione homeostasis as a function of quinone redox metabolism
RA Kelly, J Leedale, D Calleja, SJ Enoch, A Harrell, AE Chadwick, ...
Scientific reports 9 (1), 6333, 2019
Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture
RA Kelly, J Leedale, A Harrell, DA Beard, LE Randle, AE Chadwick, ...
PloS one 13 (11), e0207803, 2018
Mathematical modelling of oxygen gradients in stem cell-derived liver tissue
JA Leedale, B Lucendo-Villarin, J Meseguer-Ripolles, A Kasarinaite, ...
Plos one 16 (2), e0244070, 2021
Systems toxicology approach to identifying paracetamol overdose
CL Mason, J Leedale, S Tasoulis, I Jarman, DJ Antoine, SD Webb
CPT: Pharmacometrics & Systems Pharmacology 7 (6), 394-403, 2018
In silico-guided optimisation of oxygen gradients in hepatic spheroids
J Leedale, HE Colley, H Gaskell, DP Williams, RN Bearon, AE Chadwick, ...
Computational Toxicology 12, 100093, 2019
Preparation of primary rat hepatocyte spheroids utilizing the liquid‐overlay technique
JA Kyffin, CR Cox, J Leedale, HE Colley, C Murdoch, P Mistry, SD Webb, ...
Current protocols in toxicology 81 (1), e87, 2019
A combined in vitro/in silico approach to identifying off-target receptor toxicity
J Leedale, KJ Sharkey, HE Colley, M Norton, D Peeney, CL Mason, ...
Iscience 4, 84-96, 2018
A mathematical investigation into the uptake kinetics of nanoparticles in vitro
H West, F Roberts, P Sweeney, S Walker-Samuel, J Leedale, H Colley, ...
Plos one 16 (7), e0254208, 2021
A systems toxicology paracetamol overdose framework: accounting for high-risk individuals
CL Mason, J Leedale, S Tasoulis, I Jarman, SD Webb
Computational Toxicology 12, 100103, 2019
Using Read-Across to build Physiologically-Based Kinetic models: Part 2. Case studies for atenolol and flumioxazin
CV Thompson, SD Webb, JA Leedale, PE Penson, A Paini, D Ebbrell, ...
Computational Toxicology 29, 100293, 2024
Using read-across to build physiologically-based kinetic models: Part 1. Development of a KNIME workflow to assist analogue selection for PBK modelling
CV Thompson, SD Webb, JA Leedale, PE Penson, A Paini, D Ebbrell, ...
Computational Toxicology 29, 100292, 2024
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