| Tight control of hypoxia-inducible factor-α transient dynamics is essential for cell survival in hypoxia J Bagnall, J Leedale, SE Taylor, DG Spiller, MRH White, KJ Sharkey, ... Journal of Biological Chemistry 289 (9), 5549-5564, 2014 | 71 | 2014 |
| Impact of cell types and culture methods on the functionality of in vitro liver systems–A review of cell systems for hepatotoxicity assessment JA Kyffin, P Sharma, J Leedale, HE Colley, C Murdoch, P Mistry, ... Toxicology In Vitro 48, 262-275, 2018 | 62 | 2018 |
| Projecting malaria hazard from climate change in eastern Africa using large ensembles to estimate uncertainty J Leedale, AM Tompkins, C Caminade, AE Jones, G Nikulin, AP Morse Geospatial health 11, 102-114, 2016 | 50 | 2016 |
| Characterisation of a functional rat hepatocyte spheroid model JA Kyffin, P Sharma, J Leedale, HE Colley, C Murdoch, AL Harding, ... Toxicology in Vitro 55, 160-172, 2019 | 45 | 2019 |
| Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms CS Pridgeon, C Schlott, MW Wong, MB Heringa, T Heckel, J Leedale, ... Archives of toxicology 92, 557-569, 2018 | 41 | 2018 |
| Multiscale modelling of drug transport and metabolism in liver spheroids JA Leedale, JA Kyffin, AL Harding, HE Colley, C Murdoch, P Sharma, ... Interface focus 10 (2), 20190041, 2020 | 40 | 2020 |
| Environmental change and Rift Valley fever in eastern Africa: projecting beyond HEALTHY FUTURES D Taylor, M Hagenlocher, AE Jones, S Kienberger, J Leedale, AP Morse Geospatial Health 11 (s1), 2016 | 36 | 2016 |
| Modeling the dynamics of hypoxia inducible factor-1α (HIF-1α) within single cells and 3D cell culture systems J Leedale, A Herrmann, J Bagnall, A Fercher, D Papkovsky, V Sée, ... Mathematical biosciences 258, 33-43, 2014 | 36 | 2014 |
| A dynamic, climate-driven model of Rift Valley fever J Leedale, AE Jones, C Caminade, AP Morse Geospatial health 11 (s1), 2016 | 25 | 2016 |
| Modelling changes in glutathione homeostasis as a function of quinone redox metabolism RA Kelly, J Leedale, D Calleja, SJ Enoch, A Harrell, AE Chadwick, ... Scientific reports 9 (1), 6333, 2019 | 24 | 2019 |
| Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture RA Kelly, J Leedale, A Harrell, DA Beard, LE Randle, AE Chadwick, ... PloS one 13 (11), e0207803, 2018 | 14 | 2018 |
| Mathematical modelling of oxygen gradients in stem cell-derived liver tissue JA Leedale, B Lucendo-Villarin, J Meseguer-Ripolles, A Kasarinaite, ... Plos one 16 (2), e0244070, 2021 | 13 | 2021 |
| Systems toxicology approach to identifying paracetamol overdose CL Mason, J Leedale, S Tasoulis, I Jarman, DJ Antoine, SD Webb CPT: Pharmacometrics & Systems Pharmacology 7 (6), 394-403, 2018 | 11 | 2018 |
| In silico-guided optimisation of oxygen gradients in hepatic spheroids J Leedale, HE Colley, H Gaskell, DP Williams, RN Bearon, AE Chadwick, ... Computational Toxicology 12, 100093, 2019 | 10 | 2019 |
| Preparation of primary rat hepatocyte spheroids utilizing the liquid‐overlay technique JA Kyffin, CR Cox, J Leedale, HE Colley, C Murdoch, P Mistry, SD Webb, ... Current Protocols in Toxicology 81 (1), e87, 2019 | 9 | 2019 |
| A combined in vitro/in silico approach to identifying off-target receptor toxicity J Leedale, KJ Sharkey, HE Colley, ÁM Norton, D Peeney, CL Mason, ... Iscience 4, 84-96, 2018 | 5 | 2018 |
| A mathematical investigation into the uptake kinetics of nanoparticles in vitro H West, F Roberts, P Sweeney, S Walker-Samuel, J Leedale, H Colley, ... Plos one 16 (7), e0254208, 2021 | 4 | 2021 |
| A systems toxicology paracetamol overdose framework: accounting for high-risk individuals CL Mason, J Leedale, S Tasoulis, I Jarman, SD Webb Computational Toxicology 12, 100103, 2019 | 2 | 2019 |
| Using Read-Across to build Physiologically-Based Kinetic models: Part 2. Case studies for atenolol and flumioxazin CV Thompson, SD Webb, JA Leedale, PE Penson, A Paini, D Ebbrell, ... Computational Toxicology 29, 100293, 2024 | 1 | 2024 |
| Using read-across to build physiologically-based kinetic models: Part 1. Development of a KNIME workflow to assist analogue selection for PBK modelling CV Thompson, SD Webb, JA Leedale, PE Penson, A Paini, D Ebbrell, ... Computational Toxicology 29, 100292, 2024 | 1 | 2024 |
Steven WebbReader in Applied Mathematics, Liverpool John Moores UniversityVerified email at ljmu.ac.uk
