Pamela Lochhead
Pamela Lochhead
Verified email at babraham.ac.uk
TitleCited byYear
5-Aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.
PA Lochhead, IP Salt, KS Walker, DG Hardie, C Sutherland
Diabetes 49 (6), 896-903, 2000
4462000
Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs
PA Lochhead, G Sibbet, N Morrice, V Cleghon
Cell 121 (6), 925-936, 2005
2552005
Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression
PA Lochhead, M Coghlan, SQJ Rice, C Sutherland
Diabetes 50 (5), 937-946, 2001
2502001
A chaperone-dependent GSK3β transitional intermediate mediates activation-loop autophosphorylation
PA Lochhead, R Kinstrie, G Sibbet, T Rawjee, N Morrice, V Cleghon
Molecular cell 24 (4), 627-633, 2006
2402006
Activating ROCK1 somatic mutations in human cancer
PA Lochhead, G Wickman, M Mezna, MF Olson
Oncogene 29 (17), 2591, 2010
792010
ERK5 and its role in tumour development
PA Lochhead, R Gilley, SJ Cook
Biochemical Society Transactions 40 (1), 251-256, 2012
772012
Protein kinase activation loop autophosphorylation in cis: overcoming a Catch-22 situation
PA Lochhead
Sci. Signal. 2 (54), pe4-pe4, 2009
652009
dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila
PA Lochhead, G Sibbet, R Kinstrie, T Cleghon, M Rylatt, DK Morrison, ...
Biochemical Journal 374 (2), 381-391, 2003
512003
Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of rapamycin, but independent of ribosomal S6 kinase …
S Patel, PA Lochhead, G Rena, S Fumagalli, M Pende, SC Kozma, ...
Journal of Biological Chemistry 277 (12), 9889-9895, 2002
472002
Characterization of a domain that transiently converts class 2 DYRKs into intramolecular tyrosine kinases
R Kinstrie, N Luebbering, D Miranda-Saavedra, G Sibbet, J Han, ...
Sci. Signal. 3 (111), ra16-ra16, 2010
372010
DYRK1A-mediated cyclin D1 degradation in neural stem cells contributes to the neurogenic cortical defects in down syndrome
S Najas, J Arranz, PA Lochhead, AL Ashford, D Oxley, JM Delabar, ...
EBioMedicine 2 (2), 120-134, 2015
352015
A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr286, not Thr288
AL Ashford, D Oxley, J Kettle, K Hudson, S Guichard, SJ Cook, ...
Biochemical Journal 457 (1), 43-56, 2014
252014
dDYRK2 and Minibrain interact with the chromatin remodelling factors SNR1 and TRX
R Kinstrie, PA Lochhead, G Sibbet, N Morrice, V Cleghon
Biochemical Journal 398 (1), 45-54, 2006
242006
CDK1, not ERK1/2 or ERK5, is required for mitotic phosphorylation of BIMEL
R Gilley, PA Lochhead, K Balmanno, D Oxley, J Clark, SJ Cook
Cellular signalling 24 (1), 170-180, 2012
172012
Salt IP Walker KS Hardie DG Sutherland C. 5-Aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and …
PA Lochhead
Diabetes 49 (6), 896-903, 2000
172000
Antagonistic effects of phorbol esters on insulin regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) but not glucose-6-phosphatase gene expression
S Patel, PA Lochhead, R Graham, C Sutherland
Biochemical Journal 359 (3), 611-619, 2001
152001
Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation
PA Lochhead, J Clark, LZ Wang, L Gilmour, M Squires, R Gilley, C Foxton, ...
Cell Cycle 15 (4), 506-518, 2016
132016
The Rho-regulated ROCK kinases in cancer
GR Wickman, MS Samuel, PA Lochhead, MF Olson
The Rho GTPases in Cancer, 163-192, 2010
92010
Insulin regulation of IGF-binding protein-1 gene expression is dependent on mammalian target of rapamycin, but independent of ribosomal S6 kinase activity
S Patel, PA Lochhead, G Rena, S Fumagalli, M Pende, S Kozma, ...
Journal of Biological Chemistry, 2002
92002
Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome
AL Ashford, TPJ Dunkley, M Cockerill, RA Rowlinson, LM Baak, R Gallo, ...
Cellular and molecular life sciences 73 (4), 883-900, 2016
52016
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