Rachel E. Hewitt
Rachel E. Hewitt
Department of Veterinary Medicine, University of Cambridge
Verified email at cam.ac.uk
TitleCited byYear
High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay
MP Crawford, SX Yan, SB Ortega, RS Mehta, RE Hewitt, DA Price, ...
Blood 103 (11), 4222-4231, 2004
The bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is …
RE Hewitt, A Lissina, AE Green, ES Slay, DA Price, AK Sewell
Clinical & Experimental Immunology 139 (1), 101-111, 2005
High incidence of spontaneous disease in an HLA-DR15 and TCR transgenic multiple sclerosis model
S Ellmerich, M Mycko, K Takacs, H Waldner, FN Wahid, RJ Boyton, ...
The Journal of Immunology 174 (4), 1938-1946, 2005
Recognition of nonpeptide antigens by human Vγ9Vδ2 T cells requires contact with cells of human origin
AE Green, A Lissina, SL Hutchinson, RE Hewitt, B Temple, D James, ...
Clinical & Experimental Immunology 136 (3), 472-482, 2004
An endogenous nanomineral chaperones luminal antigen and peptidoglycan to intestinal immune cells
JJ Powell, E Thomas-McKay, V Thoree, J Robertson, RE Hewitt, ...
Nature nanotechnology 10 (4), 361-369, 2015
MHC class I molecules with superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs
L Wooldridge, M Clement, A Lissina, ESJ Edwards, K Ladell, J Ekeruche, ...
The Journal of Immunology, ji_0902398, 2010
Immuno-inhibitory PD-L1 can be induced by a Peptidoglycan/NOD2 mediated pathway in primary monocytic cells and is deficient in Crohn's patients with homozygous NOD2 mutations.
RE Hewitt, LC Pele, M Tremelling, A Metz, M Parkes, JJ Powell
Clinical immunology 143 (2), 162-169, 2012
Synthetic mimetics of the endogenous gastrointestinal nanomineral: silent constructs that trap macromolecules for intracellular delivery
LC Pele, CT Haas, RE Hewitt, J Robertson, J Skepper, A Brown, ...
Nanomedicine: Nanotechnology, Biology and Medicine 13 (2), 619-630, 2017
Intestinal APCs of the endogenous nanomineral pathway fail to express PD-L1 in Crohn’s disease
J Robertson, CT Haas, LC Pele, TP Monie, C Charalambos, M Parkes, ...
Scientific reports 6, 26747, 2016
Artefactual nanoparticle activation of the inflammasome platform: in vitro evidence with a nano-formed calcium phosphate
L Pele, CT Haas, R Hewitt, N Faria, A Brown, J Powell
Nanomedicine 10 (9), 1379-1390, 2015
Imaging flow cytometry assays for quantifying pigment grade titanium dioxide particle internalization and interactions with immune cells in whole blood
RE Hewitt, B Vis, LC Pele, N Faria, JJ Powell
Cytometry Part A 91 (10), 1009-1020, 2017
Pro-inflammatory adjuvant properties of pigment-grade titanium dioxide particles are augmented by a genotype that potentiates interleukin 1β processing
S Riedle, LC Pele, DE Otter, RE Hewitt, H Singh, NC Roy, JJ Powell
Particle and fibre toxicology 14 (1), 51, 2017
Non-functionalized ultrasmall silica nanoparticles directly and size-selectively activate T cells
B Vis, RE Hewitt, N Faria, C Bastos, H Chappell, L Pele, R Jugdaohsingh, ...
ACS nano 12 (11), 10843-10854, 2018
reduction of T-helper cell responses to recall antigen Mediated by codelivery with Peptidoglycan via the intestinal nanomineral–antigen Pathway
RE Hewitt, J Robertson, CT Haas, LC Pele, JJ Powell
Frontiers in immunology 8, 284, 2017
Widening the Applicability of Human Neutrophil Elastase and Proteinase 3 Peptide Vaccines by Elucidating Immunogenic Non-HLA-A2 MHC Class I Restricted Epitopes.
RE Hewitt, JJ Melenhorst, DA Price, E Gostick, NF Hensel, JP McCoy, ...
Blood 108 (11), 3708-3708, 2006
Compositions comprising nanosilica particles and their use in methods of activating t lymphocytes for therapy
JJ Powell, NJR Faria, RE Hewitt, BM Vis, C Bastos
US Patent App. 16/324,401, 2019
Amorphous magnesium-substituted calcium phosphate compositions and their uses
JJ Powell, NJR Faria, L Pele, R Hewitt, E Thomas-McKay
US Patent App. 15/033,750, 2014
Identification of a Shared CD4+ and CD8+ T Cell Epitope within Human Neutrophil Elastase for Peptide Vaccination in HLA-A02 Negative Leukemia Patients.
Q Le, JJ Melenhorst, RE Hewitt, N Hensel, AJ Barrett
Blood 110 (11), 1803-1803, 2007
Synthetic mimetics of the endogenous gastrointestinal nanomineral: Silent
RE Hewitt, J Robertson, J Skepper, A Brown, H Chappell, JJ Powell
PD-L1 expression in response to endogenously formed calcium phosphate nanoparticles in health and Crohn’s disease
RE Hewitt, J Robertson, C Haas, LC Pele, JJ Powell
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