Follow
Roland Hjerpe
Roland Hjerpe
Sygnature Discovery
Verified email at sygnaturediscovery.com
Title
Cited by
Cited by
Year
Efficient protection and isolation of ubiquitylated proteins using tandem ubiquitin‐binding entities
R Hjerpe, F Aillet, F Lopitz‐Otsoa, V Lang, P England, MS Rodriguez
EMBO reports 10 (11), 1250-1258, 2009
4922009
UBQLN2 mediates autophagy-independent protein aggregate clearance by the proteasome
R Hjerpe, JS Bett, MJ Keuss, A Solovyova, TG McWilliams, C Johnson, ...
Cell 166 (4), 935-949, 2016
2912016
Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes
R Hjerpe, Y Thomas, J Chen, A Zemla, S Curran, N Shpiro, LR Dick, ...
Biochemical Journal 441 (3), 927-939, 2012
1242012
Heterologous SUMO-2/3-ubiquitin chains optimize IκBα degradation and NF-κB activity
F Aillet, F Lopitz-Otsoa, I Egana, R Hjerpe, P Fraser, RT Hay, ...
PloS one 7 (12), e51672, 2012
712012
NEDD8 overexpression results in neddylation of ubiquitin substrates by the ubiquitin pathway
R Hjerpe, Y Thomas, T Kurz
Journal of molecular biology 421 (1), 27-29, 2012
642012
Isolation of ubiquitylated proteins using tandem ubiquitin-binding entities
F Aillet, F Lopitz-Otsoa, R Hjerpe, M Torres-Ramos, V Lang, ...
Ubiquitin family modifiers and the proteasome: reviews and protocols, 173-183, 2012
462012
Efficient approaches for characterizing ubiquitinated proteins
R Hjerpe, MS Rodríguez
Biochemical Society Transactions 36 (5), 823-827, 2008
412008
Unanchored tri‐NEDD8 inhibits PARP‐1 to protect from oxidative stress‐induced cell death
MJ Keuss, R Hjerpe, O Hsia, R Gourlay, R Burchmore, M Trost, T Kurz
The EMBO journal 38 (6), e100024, 2019
392019
Sumoylation modulates the activity of Spalt-like proteins during wing development in Drosophila
J Sánchez, A Talamillo, F Lopitz-Otsoa, C Pérez, R Hjerpe, JD Sutherland, ...
Journal of biological chemistry 285 (33), 25841-25849, 2010
312010
Tetramerization-defects of p53 result in aberrant ubiquitylation and transcriptional activity
V Lang, C Pallara, A Zabala, S Lobato-Gil, F Lopitz-Otsoa, R Farrás, ...
Molecular oncology 8 (5), 1026-1042, 2014
292014
Alternative UPS drug targets upstream the 26S proteasome
R Hjerpe, MS Rodríguez
The international journal of biochemistry & cell biology 40 (6-7), 1126-1140, 2008
282008
Oligomerization conditions Mdm2-mediated efficient p53 polyubiquitylation but not its proteasomal degradation
R Hjerpe, F Aillet, F Lopitz-Otsoa, V Lang, M Torres-Ramos, R Farrás, ...
The international journal of biochemistry & cell biology 42 (5), 725-735, 2010
152010
SUMO and ubiquitin modifications during steroid hormone synthesis and function.
A Talamillo, D Martín, R Hjerpe, J Sánchez, R Barrio
Biochemical Society Transactions 38 (Pt 1), 54-59, 2010
112010
Ubiquitin binding polypeptides
MSR Medina, R Hjerpe
US Patent 8,716,441, 2014
62014
U1A is a positive regulator of the expression of heterologous and cellular genes involved in cell proliferation and migration
E Rovira, B Moreno, N Razquin, R Hjerpe, M Gonzalez-Lopez, R Barrio, ...
Molecular Therapy-Nucleic Acids 28, 831-846, 2022
12022
Breaking Bad Proteins—Discovery Approaches and the Road to Clinic for Degraders
C Bouvier, R Lawrence, F Cavallo, W Xolalpa, A Jordan, R Hjerpe, ...
Cells 13 (7), 578, 2024
2024
Cryo-EM reveals important regulatory mechanism of the workhorses of targeted protein degradation
R Hjerpe, T Kurz
Molecular Cell 83 (13), 2159-2160, 2023
2023
Beyond cereblon IMIDs-biophysics-based discovery of novel molecular glue chemotypes
Y Zhang, J Bates, B Gourdet, L Birch, P Addis, R Hjerpe, AM Jordan
Cancer Research 83 (7_Supplement), 3429-3429, 2023
2023
The Sygnature CHARMD platform-combinatorial high-throughput assembly and review of molecular degraders
R Hjerpe, L Birch, A Brien, L Cusin, L Duffy, B Gourdet, R Lawrence, ...
Cancer Research 83 (7_Supplement), 3111-3111, 2023
2023
The system can't perform the operation now. Try again later.
Articles 1–19