Justin Legleiter
TitleCited byYear
Accelerating amyloid-β fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models
IH Cheng, K Scearce-Levie, J Legleiter, JJ Palop, H Gerstein, N Bien-Ly, ...
Journal of Biological Chemistry 282 (33), 23818-23828, 2007
ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE
SE Wahrle, H Jiang, M Parsadanian, J Legleiter, X Han, JD Fryer, ...
Journal of Biological Chemistry 279 (39), 40987-40993, 2004
Green tea (−)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models
DE Ehrnhoefer, M Duennwald, P Markovic, JL Wacker, S Engemann, ...
Human molecular genetics 15 (18), 2743-2751, 2006
Structure of gel phase DMPC determined by X-ray diffraction
S Tristram-Nagle, Y Liu, J Legleiter, JF Nagle
Biophysical journal 83 (6), 3324-3335, 2002
Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo
J Legleiter, E Mitchell, GP Lotz, E Sapp, C Ng, M DiFiglia, LM Thompson, ...
Journal of Biological Chemistry 285 (19), 14777-14790, 2010
Effect of different anti-Aβ antibodies on Aβ fibrillogenesis as assessed by atomic force microscopy
J Legleiter, DL Czilli, B Gitter, RB DeMattos, DM Holtzman, T Kowalewski
Journal of molecular biology 335 (4), 997-1006, 2004
Identifying polyglutamine protein species in situ that best predict neurodegeneration
J Miller, M Arrasate, E Brooks, CP Libeu, J Legleiter, D Hatters, J Curtis, ...
Nature chemical biology 7 (12), 925, 2011
Scanning probe acceleration microscopy (SPAM) in fluids: mapping mechanical properties of surfaces at the nanoscale
J Legleiter, M Park, B Cusick, T Kowalewski
Proceedings of the National Academy of Sciences 103 (13), 4813-4818, 2006
Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease
K Sathasivam, A Lane, J Legleiter, A Warley, B Woodman, S Finkbeiner, ...
Human molecular genetics 19 (1), 65-78, 2009
Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment
J Legleiter, GP Lotz, J Miller, J Ko, C Ng, GL Williams, S Finkbeiner, ...
Journal of Biological Chemistry 284 (32), 21647-21658, 2009
Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein
LG Nucifora, KA Burke, X Feng, N Arbez, S Zhu, J Miller, G Yang, ...
Journal of Biological Chemistry 287 (19), 16017-16028, 2012
Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle
GP Lotz, J Legleiter, R Aron, EJ Mitchell, SY Huang, C Ng, C Glabe, ...
Journal of Biological Chemistry 285 (49), 38183-38193, 2010
Collagen VI protects neurons against Aβ toxicity
JS Cheng, DB Dubal, DH Kim, J Legleiter, IH Cheng, GQ Yu, I Tesseur, ...
Nature neuroscience 12 (2), 119, 2009
Biophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration
KA Burke, EA Yates, J Legleiter
Frontiers in neurology 4, 17, 2013
The interaction of polyglutamine peptides with lipid membranes is regulated by flanking sequences associated with huntingtin
KA Burke, KJ Kauffman, CS Umbaugh, SL Frey, J Legleiter
Journal of Biological Chemistry 288 (21), 14993-15005, 2013
Solid-state NMR study of cysteine on gold nanoparticles
A Abraham, E Mihaliuk, B Kumar, J Legleiter, T Gullion
The Journal of Physical Chemistry C 114 (42), 18109-18114, 2010
Insights into fluid tapping-mode atomic force microscopy provided by numerical simulations
J Legleiter, T Kowalewski
Applied Physics Letters 87 (16), 163120, 2005
Imaging stability and average tip-sample force in tapping mode atomic force microscopy
T Kowalewski, J Legleiter
Journal of Applied Physics 99 (6), 064903, 2006
Amyloid-forming proteins alter the local mechanical properties of lipid membranes
KA Burke, EA Yates, J Legleiter
Biochemistry 52 (5), 808-817, 2013
Huntingtin disrupts lipid bilayers in a polyQ-length dependent manner
KA Burke, KM Hensal, CS Umbaugh, M Chaibva, J Legleiter
Biochimica et Biophysica Acta (BBA)-Biomembranes 1828 (8), 1953-1961, 2013
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Articles 1–20