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Paulo Roque Lino
Paulo Roque Lino
Hovione
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Title
Cited by
Cited by
Year
Annealing as a tool for the optimization of lyophilization and ensuring of the stability of protein-loaded PLGA nanoparticles
P Fonte, PR Lino, V Seabra, AJ Almeida, S Reis, B Sarmento
International journal of pharmaceutics 503 (1-2), 163-173, 2016
512016
Microencapsulated SLN: an innovative strategy for pulmonary protein delivery
DP Gaspar, C Serra, PR Lino, L Gonçalves, P Taboada, ...
International Journal of Pharmaceutics 516 (1-2), 231-246, 2017
412017
Polyol additives modulate the in vitro stability and activity of recombinant human phenylalanine hydroxylase
C Nascimento, J Leandro, PR Lino, L Ramos, AJ Almeida, IT de Almeida, ...
Applied biochemistry and biotechnology 162, 192-207, 2010
252010
Phenylalanine iminoboronates as new phenylalanine hydroxylase modulators
F Montalbano, J Leandro, GDVF Farias, PR Lino, RC Guedes, JB Vicente, ...
Rsc Advances 4 (105), 61022-61027, 2014
242014
Microfluidic production of mRNA-loaded lipid nanoparticles for vaccine applications
C Lopes, J Cristóvão, V Silvério, PR Lino, P Fonte
Expert Opinion on Drug Delivery 19 (10), 1381-1395, 2022
182022
Insights into the Regulatory Domain of Cystathionine Beta‐Synthase: Characterization of Six Variant Proteins
MIS Mendes, AS Santos, DEC Smith, PR Lino, HG Colaço, IT de Almeida, ...
Human mutation 35 (10), 1195-1202, 2014
172014
Spray freeze drying of biologics: a review and applications for inhalation delivery
S Farinha, JV Sá, PR Lino, M Galésio, J Pires, MÂ Rodrigues, ...
Pharmaceutical Research 40 (5), 1115-1140, 2023
82023
Laser diffraction as a powerful tool for amorphous solid dispersion screening and dissolution understanding
MC Paisana, PR Lino, PD Nunes, JF Pinto, J Henriques, AM Paiva
European Journal of Pharmaceutical Sciences 163, 105853, 2021
82021
In silico and in vitro tailoring of a chitosan nanoformulation of a human metabolic enzyme
PR Lino, J Leandro, M Amaro, LMD Gonçalves, P Leandro, AJ Almeida
Pharmaceutics 13 (3), 329, 2021
62021
Isothermal denaturation fluorimetry vs differential scanning fluorimetry as tools for screening of stabilizers for protein freeze-drying: Human phenylalanine hydroxylase as the …
P Leandro, PR Lino, R Lopes, J Leandro, MP Amaro, P Sousa, JB Vicente, ...
European Journal of Pharmaceutics and Biopharmaceutics 187, 1-11, 2023
12023
Systematic Modification and Evaluation of Enzyme-Loaded Chitosan Nanoparticles
PR Lino, J Leandro, L Figueiredo, MP Amaro, LMD Gonçalves, P Leandro, ...
International Journal of Molecular Sciences 22 (15), 7987, 2021
12021
Leveraging Hollow Fibre Membranes and High Boiling Point Organic Solvents in the Production of Enteric Amorphous Solid Dispersions
RF Mota, CM Portugal, P Lino, R Silva, AA Ricardo, J Vicente
2020 Virtual AIChE Annual Meeting, 2020
12020
Lyophilisation of human phenylalanine hydroxylase
PR Lino, AJ Almeida, IT de Almeida, P Leandro
FEBS JOURNAL 276, 323-323, 2009
12009
Disintegration and Dissolution Modeling for Accelerated Drug Product Process Development
P Valente, S Doktorovova, N Enes, J Henriques, P Lino, I Lopes, N Neves, ...
2017 AIChE Annual Meeting, 2017
2017
High molecular weight forms of human phenylalanine hydroxylase: the role of the ACT domain in the balance between a fully functional protein and the large inactive aggregates
J Leandro, MP Amaro, PR Lino, T Flatmark, P Leandro
FEBS JOURNAL 280, 119-119, 2013
2013
PROTEIN ENGINEERING TO OBTAIN PHENYLALANINE HYDROXYLASE PROTEINS WITH HIGHER STABILITY
PR Lino, C Lourenco, J Leandro, I Tavares de Almeida, AJ Almeida, ...
JOURNAL OF INHERITED METABOLIC DISEASE 34, S96-S96, 2011
2011
HOT N COLD formulation of biologics for the optimization of drying technologies
S Farinha, L Marques, M Galésio, J Cristóvão, MÂ Rodrigues, P Lino
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