| Is cooperative oxygen binding by hemoglobin really understood? WA Eaton, E Henry, J Hofrichter, A Mozzarelli Nature structural biology 6 (4), 351-358, 1999 | 408 | 1999 |
| Delay time of hemoglobin S polymerization prevents most cells from sickling in vivo A Mozzarelli, J Hofrichter, WA Eaton Science 237 (4814), 500-506, 1987 | 281 | 1987 |
| Pyridoxal 5'-phosphate enzymes as targets for therapeutic agents A Amadasi, M Bertoldi, R Contestabile, S Bettati, B Cellini, ... Current medicinal chemistry 14 (12), 1291-1324, 2007 | 226 | 2007 |
| Crystal structures and inhibitor binding in the octameric flavoenzyme vanillyl-alcohol oxidase: the shape of the active-site cavity controls substrate specificity A Mattevi, MW Fraaije, A Mozzarelli, L Olivi, A Coda, WJH van Berkel Structure 5 (7), 907-920, 1997 | 195 | 1997 |
| “Muscle to meat” molecular events and technological transformations: The proteomics insight G Paredi, S Raboni, E Bendixen, AM de Almeida, A Mozzarelli Journal of proteomics 75 (14), 4275-4289, 2012 | 185 | 2012 |
| Structures of γ-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5′-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with γ-ethynyl-GABA and with the … P Storici, D De Biase, F Bossa, S Bruno, A Mozzarelli, C Peneff, ... Journal of Biological Chemistry 279 (1), 363-373, 2004 | 179 | 2004 |
| Simple, intuitive calculations of free energy of binding for protein− ligand complexes. 1. Models without explicit constrained water P Cozzini, M Fornabaio, A Marabotti, DJ Abraham, GE Kellogg, ... Journal of medicinal chemistry 45 (12), 2469-2483, 2002 | 164 | 2002 |
| Oxygen binding by single crystals of hemoglobin C Rivetti, A Mozzarelli, GL Rossi, ER Henry, WA Eaton Biochemistry 32 (11), 2888-2906, 1993 | 144 | 1993 |
| T state hemoglobin binds oxygen noncooperatively with allosteric effects of protons, inositol hexaphosphate, and chloride S Bettati, A Mozzarelli Journal of Biological Chemistry 272 (51), 32050-32055, 1997 | 142 | 1997 |
| Simple, intuitive calculations of free energy of binding for protein− ligand complexes. 3. The free energy contribution of structural water molecules in HIV-1 protease complexes M Fornabaio, F Spyrakis, A Mozzarelli, P Cozzini, DJ Abraham, ... Journal of Medicinal Chemistry 47 (18), 4507-4516, 2004 | 137 | 2004 |
| Protein function in the crystal A Mozzarelli, GL Rossi Annual review of biophysics and biomolecular structure 25 (1), 343-365, 1996 | 133 | 1996 |
| The roles of water in the protein matrix: a largely untapped resource for drug discovery F Spyrakis, MH Ahmed, AS Bayden, P Cozzini, A Mozzarelli, GE Kellogg Journal of medicinal chemistry 60 (16), 6781-6827, 2017 | 132 | 2017 |
| Crystals of haemoglobin with the T quaternary structure bind oxygen noncooperatively with no Bohr effect A Mozzarelli, C Rivetti, GL Rossi, ER Henry, WA Eaton Nature 351 (6325), 416-419, 1991 | 129 | 1991 |
| New insights into allosteric mechanisms from trapping unstable protein conformations in silica gels C Viappiani, S Bettati, S Bruno, L Ronda, S Abbruzzetti, A Mozzarelli, ... Proceedings of the National Academy of Sciences 101 (40), 14414-14419, 2004 | 128 | 2004 |
| Evolution of allosteric models for hemoglobin WA Eaton, ER Henry, J Hofrichter, S Bettati, C Viappiani, A Mozzarelli IUBMB life 59 (8‐9), 586-599, 2007 | 127 | 2007 |
| Free energy of ligand binding to protein: evaluation of the contribution of water molecules by computational methods P Cozzini, M Fornabaio, A Marabotti, DJ Abraham, GE Kellogg, ... Current medicinal chemistry 11 (23), 3093-3118, 2004 | 126 | 2004 |
| Drug discovery targeting amino acid racemases P Conti, L Tamborini, A Pinto, A Blondel, P Minoprio, A Mozzarelli, ... Chemical reviews 111 (11), 6919-6946, 2011 | 125 | 2011 |
| Identification of xenoestrogens in food additives by an integrated in silico and in vitro approach A Amadasi, A Mozzarelli, C Meda, A Maggi, P Cozzini Chemical research in toxicology 22 (1), 52-63, 2009 | 115 | 2009 |
| High and low oxygen affinity conformations of T state hemoglobin S Bruno, M Bonaccio, S Bettati, C Rivetti, C Viappiani, S Abbruzzetti, ... Protein Science 10 (11), 2401-2407, 2001 | 113 | 2001 |
| Robust classification of “relevant” water molecules in putative protein binding sites A Amadasi, JA Surface, F Spyrakis, P Cozzini, A Mozzarelli, GE Kellogg Journal of medicinal chemistry 51 (4), 1063-1067, 2008 | 112 | 2008 |
