Edward W. Tate
Edward W. Tate
Imperial College London & Francis Crick Institute
Verified email at imperial.ac.uk - Homepage
TitleCited byYear
Protein myristoylation in health and disease
MH Wright, WP Heal, DJ Mann, EW Tate
Journal of chemical biology 3 (1), 19-35, 2010
1862010
Activity-based probes: discovering new biology and new drug targets
WP Heal, THT Dang, EW Tate
Chemical Society reviews 40 (1), 246-257, 2011
1582011
Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides
P Thongyoo, N Roqué-Rosell, RJ Leatherbarrow, EW Tate
Organic & biomolecular chemistry 6 (8), 1462-1470, 2008
1372008
Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach
MH Wright, B Clough, MD Rackham, K Rangachari, JA Brannigan, ...
Nature chemistry 6 (2), 112, 2014
1352014
N-Myristoyl transferase-mediated protein labelling in vivo
WP Heal, SR Wickramasinghe, RJ Leatherbarrow, EW Tate
Organic & biomolecular chemistry 6 (13), 2308-2315, 2008
1312008
Global profiling of co- and post-translationally N-myristoylated proteomes in human cells
E Thinon, RA Serwa, M Broncel, JA Brannigan, U Brassat, MH Wright, ...
Nature communications 5, 4919, 2014
1242014
Potent inhibitors of β-tryptase and human leukocyte elastase based on the MCoTI-II scaffold
P Thongyoo, C Bonomelli, RJ Leatherbarrow, EW Tate
Journal of medicinal chemistry 52 (20), 6197-6200, 2009
1152009
Multifunctional protein labeling via enzymatic N-terminal tagging and elaboration by click chemistry
WP Heal, MH Wright, E Thinon, EW Tate
Nature protocols 7 (1), 105, 2012
872012
N-myristoyltransferase from Leishmania donovani: structural and functional characterisation of a potential drug target for visceral leishmaniasis
JA Brannigan, BA Smith, Z Yu, AM Brzozowski, MR Hodgkinson, A Maroof, ...
Journal of molecular biology 396 (4), 985-999, 2010
852010
Bioorthogonal chemical tagging of protein cholesterylation in living cells
WP Heal, B Jovanovic, S Bessin, MH Wright, AI Magee, EW Tate
Chemical communications 47 (14), 4081-4083, 2011
842011
Global profiling of protein lipidation using chemical proteomic technologies
EW Tate, KA Kalesh, T Lanyon-Hogg, EM Storck, E Thinon
Current opinion in chemical biology 24, 48-57, 2015
752015
Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation
DS Guttery, B Poulin, A Ramaprasad, RJ Wall, DJP Ferguson, D Brady, ...
Cell host & microbe 16 (1), 128-140, 2014
682014
Comparing experimental and computational alanine scanning techniques for probing a prototypical protein–protein interaction
RT Bradshaw, BH Patel, EW Tate, RJ Leatherbarrow, IR Gould
Protein Engineering, Design & Selection 24 (1-2), 197-207, 2010
682010
Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum
PW Bowyer, RS Gunaratne, M Grainger, C Withers-Martinez, ...
Biochemical Journal 408 (2), 173-180, 2007
682007
Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs
AS Bell, JE Mills, GP Williams, JA Brannigan, AJ Wilkinson, T Parkinson, ...
PLoS neglected tropical diseases 6 (4), e1625, 2012
642012
N‐Myristoyltransferase: a Prospective Drug Target for Protozoan Parasites
PW Bowyer, EW Tate, RJ Leatherbarrow, AA Holder, DF Smith, KA Brown
ChemMedChem: Chemistry Enabling Drug Discovery 3 (3), 402-408, 2008
622008
A fluorescence-based assay for N-myristoyltransferase activity
V Goncalves, JA Brannigan, E Thinon, TO Olaleye, R Serwa, S Lanzarone, ...
Analytical biochemistry 421 (1), 342-344, 2012
612012
Chemical probes of surface layer biogenesis in Clostridium difficile
THT Dang, L Riva, RP Fagan, EM Storck, WP Heal, C Janoir, ...
ACS chemical biology 5 (3), 279-285, 2010
612010
Site-specific N-terminal labelling of proteins in vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry
WP Heal, SR Wickramasinghe, PW Bowyer, AA Holder, DF Smith, ...
Chemical Communications, 480-482, 2008
582008
Multifunctional Reagents for Quantitative Proteome‐Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development
M Broncel, RA Serwa, P Ciepla, E Krause, MJ Dallman, AI Magee, ...
Angewandte Chemie International Edition 54 (20), 5948-5951, 2015
572015
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