Douglas Vernimmen
Douglas Vernimmen
The Roslin Institute, University of Edinburgh
Verified email at - Homepage
Cited by
Cited by
Targeting the RNA m6A reader YTHDF2 selectively compromises cancer stem cells in acute myeloid leukemia
J Paris, M Morgan, J Campos, GJ Spencer, A Shmakova, I Ivanova, ...
Cell stem cell 25 (1), 137-148. e6, 2019
A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter
M De Gobbi, V Viprakasit, JR Hughes, C Fisher, VJ Buckle, H Ayyub, ...
Science 312 (5777), 1215-1217, 2006
Intragenic enhancers act as alternative promoters
MS Kowalczyk, JR Hughes, D Garrick, MD Lynch, JA Sharpe, ...
Molecular cell 45 (4), 447-458, 2012
Long‐range chromosomal interactions regulate the timing of the transition between poised and active gene expression
D Vernimmen, MD Gobbi, JA Sloane‐Stanley, WG Wood, DR Higgs
The EMBO journal 26 (8), 2041-2051, 2007
An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment
MD Lynch, AJH Smith, M De Gobbi, M Flenley, JR Hughes, D Vernimmen, ...
The EMBO journal 31 (2), 317-329, 2012
The hierarchy of transcriptional activation: from enhancer to promoter
D Vernimmen, WA Bickmore
Trends in Genetics 31 (12), 696-708, 2015
Yin Yang 1 cooperates with activator protein 2 to stimulate ERBB2 gene expression in mammary cancer cells
DY Begon, L Delacroix, D Vernimmen, P Jackers, R Winkler
Journal of Biological Chemistry 280 (26), 24428-24434, 2005
Cofactor competition between the ligand-bound oestrogen receptor and an intron 1 enhancer leads to oestrogen repression of ERBB2 expression in breast cancer
SP Newman, NP Bates, D Vernimmen, MG Parker, HC Hurst
Oncogene 19 (4), 490-497, 2000
Different mechanisms are implicated in ERBB2 gene overexpression in breast and in other cancers
D Vernimmen, M Gueders, S Pisvin, P Delvenne, R Winkler
British journal of cancer 89 (5), 899-906, 2003
Chromosome looping at the human α-globin locus is mediated via the major upstream regulatory element (HS− 40)
D Vernimmen, F Marques-Kranc, JA Sharpe, JA Sloane-Stanley, ...
Blood, The Journal of the American Society of Hematology 114 (19), 4253-4260, 2009
Polycomb eviction as a new distant enhancer function
D Vernimmen, MD Lynch, M De Gobbi, D Garrick, JA Sharpe, ...
Genes & development 25 (15), 1583-1588, 2011
The STAT3–IL-10–IL-6 pathway is a novel regulator of macrophage efferocytosis and phenotypic conversion in sterile liver injury
L Campana, PJ Starkey Lewis, A Pellicoro, RL Aucott, J Man, E O’Duibhir, ...
The Journal of Immunology 200 (3), 1169-1187, 2018
Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition
KM Lower, JR Hughes, M De Gobbi, S Henderson, V Viprakasit, C Fisher, ...
Proceedings of the National Academy of Sciences 106 (51), 21771-21776, 2009
Generation of bivalent chromatin domains during cell fate decisions
M De Gobbi, D Garrick, M Lynch, D Vernimmen, JR Hughes, N Goardon, ...
Epigenetics & chromatin 4, 1-12, 2011
Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping
KD Kernohan, D Vernimmen, GB Gloor, NG Bérubé
Nucleic acids research 42 (13), 8356-8368, 2014
Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions
AV Guitart, TI Panagopoulou, A Villacreces, M Vukovic, C Sepulveda, ...
Journal of Experimental Medicine 214 (3), 719-735, 2017
Identification of HTF (HER2 transcription factor) as an AP-2 (activator protein-2) transcription factor and contribution of the HTF binding site to ERBB2 gene overexpression
D Vernimmen, D Begon, C Salvador, S Gofflot, M Grooteclaes, R Winkler
Biochemical Journal 370 (1), 323-329, 2003
Understanding α‐globin gene regulation: aiming to improve the management of Thalassemia
DR Higgs, D Garrick, E Anguita, M De Gobbi, J Hughes, M Muers, ...
Annals of the New York Academy of Sciences 1054 (1), 92-102, 2005
Long‐range regulation of α‐globin gene expression
DR Higgs, D Vernimmen, B Wood
Advances in genetics 61, 143-173, 2008
Uncovering enhancer functions using the α-globin locus
D Vernimmen
PLoS genetics 10 (10), e1004668, 2014
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