Targeting the RNA m6A reader YTHDF2 selectively compromises cancer stem cells in acute myeloid leukemia J Paris, M Morgan, J Campos, GJ Spencer, A Shmakova, I Ivanova, ... Cell stem cell 25 (1), 137-148. e6, 2019 | 413 | 2019 |
A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter M De Gobbi, V Viprakasit, JR Hughes, C Fisher, VJ Buckle, H Ayyub, ... Science 312 (5777), 1215-1217, 2006 | 364 | 2006 |
Intragenic enhancers act as alternative promoters MS Kowalczyk, JR Hughes, D Garrick, MD Lynch, JA Sharpe, ... Molecular cell 45 (4), 447-458, 2012 | 319 | 2012 |
Long‐range chromosomal interactions regulate the timing of the transition between poised and active gene expression D Vernimmen, MD Gobbi, JA Sloane‐Stanley, WG Wood, DR Higgs The EMBO journal 26 (8), 2041-2051, 2007 | 305 | 2007 |
An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment MD Lynch, AJH Smith, M De Gobbi, M Flenley, JR Hughes, D Vernimmen, ... The EMBO journal 31 (2), 317-329, 2012 | 239 | 2012 |
The hierarchy of transcriptional activation: from enhancer to promoter D Vernimmen, WA Bickmore Trends in Genetics 31 (12), 696-708, 2015 | 177 | 2015 |
Yin Yang 1 cooperates with activator protein 2 to stimulate ERBB2 gene expression in mammary cancer cells DY Begon, L Delacroix, D Vernimmen, P Jackers, R Winkler Journal of Biological Chemistry 280 (26), 24428-24434, 2005 | 133 | 2005 |
Cofactor competition between the ligand-bound oestrogen receptor and an intron 1 enhancer leads to oestrogen repression of ERBB2 expression in breast cancer SP Newman, NP Bates, D Vernimmen, MG Parker, HC Hurst Oncogene 19 (4), 490-497, 2000 | 132 | 2000 |
Different mechanisms are implicated in ERBB2 gene overexpression in breast and in other cancers D Vernimmen, M Gueders, S Pisvin, P Delvenne, R Winkler British journal of cancer 89 (5), 899-906, 2003 | 125 | 2003 |
Chromosome looping at the human α-globin locus is mediated via the major upstream regulatory element (HS− 40) D Vernimmen, F Marques-Kranc, JA Sharpe, JA Sloane-Stanley, ... Blood, The Journal of the American Society of Hematology 114 (19), 4253-4260, 2009 | 115 | 2009 |
Polycomb eviction as a new distant enhancer function D Vernimmen, MD Lynch, M De Gobbi, D Garrick, JA Sharpe, ... Genes & development 25 (15), 1583-1588, 2011 | 102 | 2011 |
The STAT3–IL-10–IL-6 pathway is a novel regulator of macrophage efferocytosis and phenotypic conversion in sterile liver injury L Campana, PJ Starkey Lewis, A Pellicoro, RL Aucott, J Man, E O’Duibhir, ... The Journal of Immunology 200 (3), 1169-1187, 2018 | 99 | 2018 |
Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition KM Lower, JR Hughes, M De Gobbi, S Henderson, V Viprakasit, C Fisher, ... Proceedings of the National Academy of Sciences 106 (51), 21771-21776, 2009 | 92 | 2009 |
Generation of bivalent chromatin domains during cell fate decisions M De Gobbi, D Garrick, M Lynch, D Vernimmen, JR Hughes, N Goardon, ... Epigenetics & chromatin 4, 1-12, 2011 | 81 | 2011 |
Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping KD Kernohan, D Vernimmen, GB Gloor, NG Bérubé Nucleic acids research 42 (13), 8356-8368, 2014 | 80 | 2014 |
Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions AV Guitart, TI Panagopoulou, A Villacreces, M Vukovic, C Sepulveda, ... Journal of Experimental Medicine 214 (3), 719-735, 2017 | 79 | 2017 |
Identification of HTF (HER2 transcription factor) as an AP-2 (activator protein-2) transcription factor and contribution of the HTF binding site to ERBB2 gene overexpression D Vernimmen, D Begon, C Salvador, S Gofflot, M Grooteclaes, R Winkler Biochemical Journal 370 (1), 323-329, 2003 | 75 | 2003 |
Understanding α‐globin gene regulation: aiming to improve the management of Thalassemia DR Higgs, D Garrick, E Anguita, M De Gobbi, J Hughes, M Muers, ... Annals of the New York Academy of Sciences 1054 (1), 92-102, 2005 | 66 | 2005 |
Long‐range regulation of α‐globin gene expression DR Higgs, D Vernimmen, B Wood Advances in genetics 61, 143-173, 2008 | 58 | 2008 |
Uncovering enhancer functions using the α-globin locus D Vernimmen PLoS genetics 10 (10), e1004668, 2014 | 56 | 2014 |