Prajwal Gurung
Prajwal Gurung
Assistant Professor at the University of Iowa
Verified email at
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RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3
CP Dillon, R Weinlich, DA Rodriguez, JG Cripps, G Quarato, P Gurung, ...
Cell 157 (5), 1189-1202, 2014
FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes
P Gurung, PK Anand, RKS Malireddi, LV Walle, N Van Opdenbosch, ...
The Journal of Immunology 192 (4), 1835-1846, 2014
Mitochondria: diversity in the regulation of the NLRP3 inflammasome
P Gurung, JR Lukens, TD Kanneganti
Trends in molecular medicine 21 (3), 193-201, 2015
Critical role for the DNA sensor AIM2 in stem cell proliferation and cancer
SM Man, Q Zhu, L Zhu, Z Liu, R Karki, A Malik, D Sharma, L Li, ...
Cell 162 (1), 45-58, 2015
Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-β (TRIF)-mediated caspase-11 protease production integrates Toll-like receptor 4 (TLR4 …
P Gurung, RKS Malireddi, PK Anand, D Demon, LV Walle, Z Liu, P Vogel, ...
Journal of Biological Chemistry 287 (41), 34474-34483, 2012
Dietary modulation of the microbiome affects autoinflammatory disease
JR Lukens, P Gurung, P Vogel, GR Johnson, RA Carter, DJ McGoldrick, ...
Nature 516 (7530), 246-249, 2014
Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection
R Karki, SM Man, RKS Malireddi, P Gurung, P Vogel, M Lamkanfi, ...
Cell host & microbe 17 (3), 357-368, 2015
Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation
N Van Opdenbosch, P Gurung, LV Walle, A Fossoul, TD Kanneganti, ...
Nature communications 5 (1), 1-14, 2014
Protective roles for caspase-8 and cFLIP in adult homeostasis
R Weinlich, A Oberst, CP Dillon, LJ Janke, S Milasta, JR Lukens, ...
Cell reports 5 (2), 340-348, 2013
Role of inflammasomes in host defense against Citrobacter rodentium infection
Z Liu, MH Zaki, P Vogel, P Gurung, BB Finlay, W Deng, M Lamkanfi, ...
Journal of Biological chemistry 287 (20), 16955-16964, 2012
Novel roles for caspase-8 in IL-1β and inflammasome regulation
P Gurung, TD Kanneganti
The American journal of pathology 185 (1), 17-25, 2015
NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells
SW Paugh, EJ Bonten, D Savic, LB Ramsey, WE Thierfelder, P Gurung, ...
Nature genetics 47 (6), 607-614, 2015
Chronic TLR stimulation controls NLRP3 inflammasome activation through IL-10 mediated regulation of NLRP3 expression and caspase-8 activation
P Gurung, B Li, RKS Malireddi, M Lamkanfi, TL Geiger, TD Kanneganti
Scientific reports 5 (1), 1-10, 2015
Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation
Q Zhu, SM Man, P Gurung, Z Liu, P Vogel, M Lamkanfi, TD Kanneganti
The Journal of Immunology 193 (10), 4779-4782, 2014
An NLRP3 inflammasome–triggered Th2-biased adaptive immune response promotes leishmaniasis
P Gurung, R Karki, P Vogel, M Watanabe, M Bix, M Lamkanfi, ...
The Journal of clinical investigation 125 (3), 1329-1338, 2015
TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation
RKS Malireddi, P Gurung, J Mavuluri, TK Dasari, JM Klco, H Chi, ...
Journal of Experimental Medicine 215 (4), 1023-1034, 2018
The NLRP12 sensor negatively regulates autoinflammatory disease by modulating interleukin-4 production in T cells
JR Lukens, P Gurung, PJ Shaw, MJ Barr, MH Zaki, SA Brown, P Vogel, ...
Immunity 42 (4), 654-664, 2015
Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity–independent pyroptosis, apoptosis, necroptosis, and inflammatory disease
RK Malireddi, P Gurung, S Kesavardhana, P Samir, A Burton, ...
Journal of Experimental Medicine 217 (3), 2020
Innate immunity against Leishmania infections
P Gurung, TD Kanneganti
Cellular microbiology 17 (9), 1286-1294, 2015
Recent advances in lipopolysaccharide recognition systems
L Mazgaeen, P Gurung
International journal of molecular sciences 21 (2), 379, 2020
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