|Human tumor-associated macrophage and monocyte transcriptional landscapes reveal cancer-specific reprogramming, biomarkers, and therapeutic targets|
L Cassetta, S Fragkogianni, AH Sims, A Swierczak, LM Forrester, ...
Cancer cell 35 (4), 588-602. e10, 2019
|MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures|
T Mondal, S Subhash, R Vaid, S Enroth, S Uday, B Reinius, S Mitra, ...
Nature communications 6 (1), 7743, 2015
|Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity|
A Serrels, T Lund, B Serrels, A Byron, RC McPherson, A von Kriegsheim, ...
Cell 163 (1), 160-173, 2015
|Origins of breast cancer subtypes and therapeutic implications|
AH Sims, A Howell, SJ Howell, RB Clarke
Nature Clinical Practice Oncology 4 (9), 516-525, 2007
|Anti-estrogen resistance in human breast tumors is driven by JAG1-NOTCH4-dependent cancer stem cell activity|
BM Simoes, CS O’Brien, R Eyre, A Silva, L Yu, A Sarmiento-Castro, ...
Cell reports 12 (12), 1968-1977, 2015
|The removal of multiplicative, systematic bias allows integration of breast cancer gene expression datasets–improving meta-analysis and prediction of prognosis|
AH Sims, GJ Smethurst, Y Hey, MJ Okoniewski, SD Pepper, A Howell, ...
BMC medical genomics 1, 1-14, 2008
|Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns|
D Sproul, RR Kitchen, CE Nestor, JM Dixon, AH Sims, DJ Harrison, ...
Genome biology 13 (10), 1-16, 2012
|Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer|
D Sproul, C Nestor, J Culley, JH Dickson, JM Dixon, DJ Harrison, ...
Proceedings of the National Academy of Sciences 108 (11), 4364-4369, 2011
|MCL-1 is a prognostic indicator and drug target in breast cancer|
KJ Campbell, S Dhayade, N Ferrari, AH Sims, E Johnson, SM Mason, ...
Cell death & disease 9 (2), 19, 2018
|Immune cell gene signatures for profiling the microenvironment of solid tumors|
AJ Nirmal, T Regan, BB Shih, DA Hume, AH Sims, TC Freeman
Cancer immunology research 6 (11), 1388-1400, 2018
|Wnt pathway activity in breast cancer sub-types and stem-like cells|
R Lamb, MP Ablett, K Spence, G Landberg, AH Sims, RB Clarke
PloS one 8 (7), e67811, 2013
|KIBRA exhibits MST-independent functional regulation of the Hippo signaling pathway in mammals|
S Moleirinho, N Chang, AH Sims, AM Tilston-Lünel, L Angus, A Steele, ...
Oncogene 32 (14), 1821-1830, 2013
|Cyclin D1, Id1 and EMT in breast cancer|
NP Tobin, AH Sims, KL Lundgren, S Lehn, G Landberg
BMC cancer 11, 1-14, 2011
|Accurate prediction and validation of response to endocrine therapy in breast cancer|
AK Turnbull, LM Arthur, L Renshaw, AA Larionov, C Kay, AK Dunbier, ...
Journal of Clinical Oncology 33 (20), 2270-2278, 2015
|Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling|
R Eyre, DG Alférez, A Santiago-Gómez, K Spence, JC McConnell, C Hart, ...
Nature communications 10 (1), 5016, 2019
|Effects of oestrogen on gene expression in epithelium and stroma of normal human breast tissue|
CL Wilson, AH Sims, A Howell, CJ Miller, RB Clarke
Endocrine-related cancer 13 (2), 617-628, 2006
|The embryonic transcription cofactor LBH is a direct target of the Wnt signaling pathway in epithelial development and in aggressive basal subtype breast cancers|
ME Rieger, AH Sims, ER Coats, RB Clarke, KJ Briegel
Molecular and cellular biology 30 (17), 4267-4279, 2010
|Transcriptome Analysis of Recombinant Protein Secretion by Aspergillus nidulans and the Unfolded-Protein Response In Vivo|
AH Sims, ME Gent, K Lanthaler, NS Dunn-Coleman, SG Oliver, ...
Applied and environmental microbiology 71 (5), 2737-2747, 2005
|Accurate prediction of response to endocrine therapy in breast cancer patients: current and future biomarkers|
C Selli, JM Dixon, AH Sims
Breast Cancer Research 18 (1), 1-10, 2016
|PIK3CA genotype and a PIK3CA mutation-related gene signature and response to everolimus and letrozole in estrogen receptor positive breast cancer|
S Loi, S Michiels, J Baselga, JMS Bartlett, SK Singhal, VS Sabine, ...
PloS one 8 (1), e53292, 2013