| Human tumor-associated macrophage and monocyte transcriptional landscapes reveal cancer-specific reprogramming, biomarkers, and therapeutic targets L Cassetta, S Fragkogianni, AH Sims, A Swierczak, LM Forrester, ... Cancer cell 35 (4), 588-602. e10, 2019 | 636 | 2019 |
| MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures T Mondal, S Subhash, R Vaid, S Enroth, S Uday, B Reinius, S Mitra, ... Nature communications 6 (1), 7743, 2015 | 596 | 2015 |
| Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity A Serrels, T Lund, B Serrels, A Byron, RC McPherson, A von Kriegsheim, ... Cell 163 (1), 160-173, 2015 | 366 | 2015 |
| Origins of breast cancer subtypes and therapeutic implications AH Sims, A Howell, SJ Howell, RB Clarke Nature Clinical Practice Oncology 4 (9), 516-525, 2007 | 258 | 2007 |
| Anti-estrogen resistance in human breast tumors is driven by JAG1-NOTCH4-dependent cancer stem cell activity BM Simoes, CS O’Brien, R Eyre, A Silva, L Yu, A Sarmiento-Castro, ... Cell reports 12 (12), 1968-1977, 2015 | 187 | 2015 |
| The removal of multiplicative, systematic bias allows integration of breast cancer gene expression datasets–improving meta-analysis and prediction of prognosis AH Sims, GJ Smethurst, Y Hey, MJ Okoniewski, SD Pepper, A Howell, ... BMC medical genomics 1, 1-14, 2008 | 182 | 2008 |
| Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns D Sproul, RR Kitchen, CE Nestor, JM Dixon, AH Sims, DJ Harrison, ... Genome biology 13 (10), 1-16, 2012 | 177 | 2012 |
| Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer D Sproul, C Nestor, J Culley, JH Dickson, JM Dixon, DJ Harrison, ... Proceedings of the National Academy of Sciences 108 (11), 4364-4369, 2011 | 176 | 2011 |
| MCL-1 is a prognostic indicator and drug target in breast cancer KJ Campbell, S Dhayade, N Ferrari, AH Sims, E Johnson, SM Mason, ... Cell death & disease 9 (2), 19, 2018 | 162 | 2018 |
| Immune cell gene signatures for profiling the microenvironment of solid tumors AJ Nirmal, T Regan, BB Shih, DA Hume, AH Sims, TC Freeman Cancer immunology research 6 (11), 1388-1400, 2018 | 158 | 2018 |
| Wnt pathway activity in breast cancer sub-types and stem-like cells R Lamb, MP Ablett, K Spence, G Landberg, AH Sims, RB Clarke PloS one 8 (7), e67811, 2013 | 154 | 2013 |
| KIBRA exhibits MST-independent functional regulation of the Hippo signaling pathway in mammals S Moleirinho, N Chang, AH Sims, AM Tilston-Lünel, L Angus, A Steele, ... Oncogene 32 (14), 1821-1830, 2013 | 137 | 2013 |
| Cyclin D1, Id1 and EMT in breast cancer NP Tobin, AH Sims, KL Lundgren, S Lehn, G Landberg BMC cancer 11, 1-14, 2011 | 131 | 2011 |
| Accurate prediction and validation of response to endocrine therapy in breast cancer AK Turnbull, LM Arthur, L Renshaw, AA Larionov, C Kay, AK Dunbier, ... Journal of Clinical Oncology 33 (20), 2270-2278, 2015 | 122 | 2015 |
| Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling R Eyre, DG Alférez, A Santiago-Gómez, K Spence, JC McConnell, C Hart, ... Nature communications 10 (1), 5016, 2019 | 106 | 2019 |
| Effects of oestrogen on gene expression in epithelium and stroma of normal human breast tissue CL Wilson, AH Sims, A Howell, CJ Miller, RB Clarke Endocrine-related cancer 13 (2), 617-628, 2006 | 105 | 2006 |
| The embryonic transcription cofactor LBH is a direct target of the Wnt signaling pathway in epithelial development and in aggressive basal subtype breast cancers ME Rieger, AH Sims, ER Coats, RB Clarke, KJ Briegel Molecular and cellular biology 30 (17), 4267-4279, 2010 | 104 | 2010 |
| Transcriptome Analysis of Recombinant Protein Secretion by Aspergillus nidulans and the Unfolded-Protein Response In Vivo AH Sims, ME Gent, K Lanthaler, NS Dunn-Coleman, SG Oliver, ... Applied and environmental microbiology 71 (5), 2737-2747, 2005 | 104 | 2005 |
| Accurate prediction of response to endocrine therapy in breast cancer patients: current and future biomarkers C Selli, JM Dixon, AH Sims Breast Cancer Research 18 (1), 1-10, 2016 | 95 | 2016 |
| PIK3CA genotype and a PIK3CA mutation-related gene signature and response to everolimus and letrozole in estrogen receptor positive breast cancer S Loi, S Michiels, J Baselga, JMS Bartlett, SK Singhal, VS Sabine, ... PloS one 8 (1), e53292, 2013 | 91 | 2013 |
Robert B ClarkeProfessor of Breast Biology, University of ManchesterVerified email at manchester.ac.uk
