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Alexander Garvin
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Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection
RM Densham, AJ Garvin, HR Stone, J Strachan, RA Baldock, ...
Nature structural & molecular biology 23 (7), 647-655, 2016
2752016
The proteasomal de‐ubiquitinating enzyme POH1 promotes the double‐strand DNA break response
LR Butler, RM Densham, J Jia, AJ Garvin, HR Stone, V Shah, D Weekes, ...
The EMBO journal 31 (19), 3918-3934, 2012
1592012
The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair
AJ Garvin, RM Densham, SA Blair‐Reid, KM Pratt, HR Stone, D Weekes, ...
EMBO reports 14 (11), 975-983, 2013
1072013
Isomerization of BRCA1–BARD1 promotes replication fork protection
M Daza-Martin, K Starowicz, M Jamshad, S Tye, GE Ronson, HL MacKay, ...
Nature 571 (7766), 521-527, 2019
1032019
Sunlight Generates Multiple Tryptophan Photoproducts Eliciting High Efficacy CYP1A Induction in Chick Hepatocytes and In Vivo
S Diani-Moore, E Labitzke, R Brown, A Garvin, L Wong, AB Rifkind
Toxicological Sciences 90 (1), 96-110, 2006
762006
SUMO, a small, but powerful, regulator of double-strand break repair
AJ Garvin, JR Morris
Philosophical Transactions of the Royal Society B: Biological Sciences 372 …, 2017
742017
A ChIP–chip approach reveals a novel role for transcription factor IRF1 in the DNA damage response
M Frontini, M Vijayakumar, A Garvin, N Clarke
Nucleic acids research 37 (4), 1073-1085, 2009
722009
The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms
AJ Garvin, AK Walker, RM Densham, AS Chauhan, HR Stone, HL Mackay, ...
Genes & Development 33 (5-6), 333-347, 2019
362019
SUMO in the DNA double-stranded break response: similarities, differences, and cooperation with ubiquitin
JR Morris, AJ Garvin
Journal of molecular biology 429 (22), 3376-3387, 2017
322017
GSK3β-SCFFBXW7α mediated phosphorylation and ubiquitination of IRF1 are required for its transcription-dependent turnover
AJ Garvin, AHA Khalaf, A Rettino, J Xicluna, L Butler, JR Morris, ...
Nucleic acids research 47 (9), 4476-4494, 2019
242019
Beyond reversal: ubiquitin and ubiquitin-like proteases and the orchestration of the DNA double strand break repair response
AJ Garvin
Biochemical Society Transactions 47 (6), 1881-1893, 2019
152019
SUMO monoclonal antibodies vary in sensitivity, specificity, and ability to detect types of SUMO conjugate
AJ Garvin, AJ Lanz, JR Morris
Scientific Reports 12 (1), 21343, 2022
42022
SUMO monoclonal antibodies vary in sensitivity, specificity, and ability to detect SUMO conjugate types
AJ Garvin, AJ Lanz, JR Morris
bioRxiv, 2022.03. 19.484974, 2022
22022
Mechanisms of synthetic lethality between BRCA1/2 and 53BP1 deficiencies and DNA polymerase theta targeting
GE Ronson, K Starowicz, EJ Anthony, AL Piberger, LC Clarke, AJ Garvin, ...
Nature Communications 14 (1), 7834, 2023
12023
Pin1-promoted SUMOylation of RNF168 restrains its chromatin accumulation
AS Chauhan, AJ Garvin, M Jamshad, JR Morris
bioRxiv, 2022.03. 22.485326, 2022
2022
SUMO4 regulates DNA double-strand break repair independently of conjugation
AJ Garvin, AJ Lanz, RM Densham, JR Morris
bioRxiv, 2022.03. 23.485504, 2022
2022
RAD52 underlies the synthetic-lethal relationship between BRCA1/2 and 53BP1 deficiencies and DNA polymerase theta loss
K Starowicz, G Ronson, E Anthony, L Clarke, AJ Garvin, AD Beggs, ...
bioRxiv, 2022.03. 20.485027, 2022
2022
Modification of the SUMO activating enzyme subunit SAE2 directs SUMO isoform bias required for mitotic fidelity
AK Walker, AJ Lanz, M Jamshad, AJ Garvin, P Wotherspoon, BF Cooper, ...
bioRxiv, 2022.03. 18.484840, 2022
2022
GSK3β-SCFFBXW7 mediated phosphorylation and ubiquitination of IRF1 are required for its transcription-dependent turnover
AJ Garvin, AHA Khalaf, A Rettino, J Xicluna, L Butler, JR Morris, ...
bioRxiv, 481911, 2018
2018
Ubiquitin, SUMO and the DNA Double-Strand Break Response
RM Densham, AJ Garvin, JR Morris
DNA Repair and Replication, 167-203, 2018
2018
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