John Hadfield
John Hadfield
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Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle
A Jordan, JA Hadfield, NJ Lawrence, AT McGown
Medicinal research reviews 18 (4), 259-296, 1998
Potent antimitotic and cell growth inhibitory properties of substituted chalcones
S Ducki, R Forrest, JA Hadfield, A Kendall, NJ Lawrence, AT McGown, ...
Bioorganic & medicinal chemistry letters 8 (9), 1051-1056, 1998
Tubulin and microtubules as targets for anticancer drugs
JA Hadfield, S Ducki, N Hirst, AT McGown
Progress in Cell Cycle Research. 5, 309-326, 2003
The interaction with tubulin of a series of stilbenes based on combretastatin A-4
JA Woods, JA Hadfield, GR Pettit, BW Fox, AT McGown
British journal of cancer 71 (4), 705-711, 1995
Novel syntheses of cis and trans isomers of combretastatin A-4
K Gaukroger, JA Hadfield, LA Hepworth, NJ Lawrence, AT McGown
The Journal of organic chemistry 66 (24), 8135-8138, 2001
The total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents
NJ Lawrence, D Rennison, AT McGown, JA Hadfield
Bioorganic & medicinal chemistry letters 13 (21), 3759-3763, 2003
Structural requirements for the interaction of combretastatins with tubulin: how important is the trimethoxy unit?
K Gaukroger, JA Hadfield, NJ Lawrence, S Nolan, AT McGown
Organic & biomolecular chemistry 1 (17), 3033-3037, 2003
The interaction of chalcones with tubulin
NJ Lawrence, AT McGown, S Ducki, JA Hadfield
Anti-cancer drug design 15 (2), 135-141, 2000
Synthesis and biological evaluation of 2-and 3-aminobenzo [b] thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization
R Romagnoli, PG Baraldi, MD Carrion, CL Cara, D Preti, F Fruttarolo, ...
Journal of medicinal chemistry 50 (9), 2273-2277, 2007
Linked parallel synthesis and MTT bioassay screening of substituted chalcones
NJ Lawrence, D Rennison, AT McGown, S Ducki, LA Gul, JA Hadfield, ...
Journal of combinatorial chemistry 3 (5), 421-426, 2001
Isoflavones inhibit intestinal epithelial cell proliferation and induce apoptosis in vitro
C Booth, DF Hargreaves, JA Hadfield, AT McGown, CS Potten
British Journal of Cancer 80 (10), 1550-1557, 1999
Comparison of different busulfan analogues for depletion of hematopoietic stem cells and promotion of donor-type chimerism in murine bone marrow transplant recipients
GR Westerhof, RE Ploemacher, A Boudewijn, I Blokland, JH Dillingh, ...
Cancer Research 60 (19), 5470-5478, 2000
The effect of ifosfamide and its metabolites on intracellular glutathione levels in vitro and in vivo
MJ Lind, AT McGown, JA Hadfield, N Thatcher, D Crowther, BW Fox
Biochemical pharmacology 38 (11), 1835-1840, 1989
Reaction of Baylis–Hillman products with Swern and Dess–Martin oxidants
NJ Lawrence, JP Crump, AT McGown, JA Hadfield
Tetrahedron Letters 42 (23), 3939-3941, 2001
Cytotoxic michael-type amine adducts of α-methylene lactones alantolactone and isoalantolactone
NJ Lawrence, AT McGown, J Nduka, JA Hadfield, RG Pritchard
Bioorganic & medicinal chemistry letters 11 (3), 429-431, 2001
Synthesis and anticancer activity of fluorinated analogues of combretastatin A-4
NJ Lawrence, LA Hepworth, D Rennison, AT McGown, JA Hadfield
Journal of fluorine chemistry 123 (1), 101-108, 2003
Isolation of E-1-(4′-Hydroxyphenyl)-but-1-en-2-one from Scutellaria barbata
S Ducki, JA Hadfield, NJ Lawrence, CY Liu, AT McGown, X Zhang
Planta medica 62 (02), 185-186, 1996
Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers
NJ Lawrence, D Rennison, M Woo, AT McGown, JA Hadfield
Bioorganic & medicinal chemistry letters 11 (1), 51-54, 2001
The synthesis of (E) and (Z)-combretastatins A-4 and a phenanthrene from Combretum caffrum
NJ Lawrence, FA Ghani, LA Hepworth, JA Hadfield, AT McGown, ...
Synthesis 1999 (09), 1656-1660, 1999
Bioactivity and molecular modelling of diphenylsulfides and diphenylselenides
JA Woods, JA Hadfield, AT McGown, BW Fox
Bioorganic & medicinal chemistry 1 (5), 333-340, 1993
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