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Robert Langan
Robert Langan
Scientist, Outpace Bio
Verified email at outpacebio.com
Title
Cited by
Cited by
Year
De novo design of protein homo-oligomers with modular hydrogen-bond network–mediated specificity
SE Boyken, Z Chen, B Groves, RA Langan, G Oberdorfer, A Ford, ...
Science 352 (6286), 680-687, 2016
3542016
De novo design of bioactive protein switches
RA Langan, SE Boyken, AH Ng, JA Samson, G Dods, AM Westbrook, ...
Nature 572 (7768), 205-210, 2019
2502019
Programmable design of orthogonal protein heterodimers
Z Chen, SE Boyken, M Jia, F Busch, D Flores-Solis, MJ Bick, P Lu, ...
Nature 565 (7737), 106-111, 2019
1802019
De novo design of modular and tunable protein biosensors
A Quijano-Rubio, HW Yeh, J Park, H Lee, RA Langan, SE Boyken, ...
Nature 591 (7850), 482-487, 2021
1772021
Designed protein logic to target cells with precise combinations of surface antigens
MJ Lajoie, SE Boyken, AI Salter, J Bruffey, A Rajan, RA Langan, ...
Science 369 (6511), 1637-1643, 2020
1442020
Modular and tunable biological feedback control using a de novo protein switch
AH Ng, TH Nguyen, M Gómez-Schiavon, G Dods, RA Langan, SE Boyken, ...
Nature 572 (7768), 265-269, 2019
1112019
Generation of ordered protein assemblies using rigid three-body fusion
I Vulovic, Q Yao, YJ Park, A Courbet, A Norris, F Busch, A Sahasrabuddhe, ...
Proceedings of the National Academy of Sciences 118 (23), e2015037118, 2021
322021
Conditional Recruitment to a DNA-Bound CRISPR–Cas Complex Using a Colocalization-Dependent Protein Switch
RL Kirkpatrick, K Lewis, RA Langan, MJ Lajoie, SE Boyken, M Eakman, ...
ACS synthetic biology 9 (9), 2316-2323, 2020
92020
De novo design of modular and tunable allosteric biosensors
A Quijano-Rubio, HW Yeh, J Park, H Lee, RA Langan, SE Boyken, ...
bioRxiv, 2020.07. 18.206946, 2020
72020
Publisher Correction: Modular and tunable biological feedback control using a de novo protein switch
AH Ng, TH Nguyen, M Gómez-Schiavon, G Dods, RA Langan, SE Boyken, ...
Nature 579 (7798), E8, 2020
32020
De novo design of protein switches
RA Langan, S Boyken, D Baker, W Novak, MJ Lajoie, AQ RUBIO
US Patent 10,851,135, 2020
22020
De novo design of phosphorylation inducible protein switches (phospho-switches)
N Woodall, S Boyken, MJ Lajoie, C Zibo, RA Langan, D Baker
US Patent App. 17/618,117, 2022
12022
Caged-degron-based molecular feedback circuits and methods of using the same
D Baker, S Boyken, ELS Hana, M Lajoie, R Langan, A Ng
US Patent App. 17/419,236, 2022
12022
Orthogonal protein heterodimers
C Zibo, S Boyken, S Bermeo, RA Langan, D Baker
US Patent App. 17/502,485, 2022
12022
De novo design of protein switches for tunable control of protein degradation
R Langan, A Ng, S Boyken, M Lajoie, ELS Hana, D Baker
US Patent App. 17/419,413, 2022
12022
heterodimers
Z Chen, SE Boyken, M Jia, F Busch, D Flores-solis, MJ Bick, P Lu, ...
Springer US, 2019
12019
De Novo Design of Bioactive Protein Switches, and Applications Thereof
RA Langan
12019
Orthogonal protein heterodimers
C Zibo, S Boyken, S Bermeo, RA Langan, D Baker
US Patent App. 18/158,384, 2024
2024
OPB-101: An optimized mesothelin-specific CAR T cell product expressing CD8-targeted IL-2/15 and engineered to resist T cell exhaustion
R Amin, H Moffett, K Haworth, J Chen, J Yokoyama, A Wang, L Tait, ...
Cancer Research 84 (6_Supplement), 51-51, 2024
2024
Outsmart™ IL-2/15, a Novel Cytokine Designed to Enhance ROR1-Specific CAR T Anti-Tumor Activity While Minimizing Treg Activation and Systemic Cytokine Exposure
H Moffett, B Weitzner, T Davenport, L Tait, T Tan, L Baker, J Crowl, ...
Blood 142, 3432, 2023
2023
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