| Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells Hendel A, Bak RO, Clark TJ, Kennedy AB, Ryan DE, Roy S, Steinfeld I, Lunstad ... Nature Biotechnology, 2015 | 1163 | 2015 |
| CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells DP Dever, RO Bak, A Reinisch, J Camarena, G Washington, CE Nicolas, ... Nature 539 (7629), 384-389, 2016 | 899 | 2016 |
| Uridine depletion and chemical modification increase Cas9 mRNA activity and reduce immunogenicity without HPLC purification S Vaidyanathan, KT Azizian, AKMA Haque, JM Henderson, A Hendel, ... Molecular Therapy-Nucleic Acids 12, 530-542, 2018 | 214 | 2018 |
| Quantifying on-and off-target genome editing A Hendel, EJ Fine, G Bao, MH Porteus Trends in biotechnology 33 (2), 132-140, 2015 | 173 | 2015 |
| PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells A Hendel, PHL Krijger, N Diamant, Z Goren, P Langerak, J Kim, ... PLoS genetics 7 (9), e1002262, 2011 | 167 | 2011 |
| Quantifying genome-editing outcomes at endogenous loci with SMRT sequencing A Hendel, EJ Kildebeck, EJ Fine, JT Clark, N Punjya, V Sebastiano, ... Cell reports 7 (1), 293-305, 2014 | 145 | 2014 |
| DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity N Diamant, A Hendel, I Vered, T Carell, T Reißner, N De Wind, ... Nucleic acids research 40 (1), 170-180, 2012 | 127 | 2012 |
| Nuclease-mediated gene editing by homologous recombination of the human globin locus RA Voit, A Hendel, SM Pruett-Miller, MH Porteus Nucleic acids research 42 (2), 1365-1378, 2014 | 120 | 2014 |
| Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells JG Jansen, A Tsaalbi-Shtylik, G Hendriks, H Gali, A Hendel, F Johansson, ... Molecular and cellular biology 29 (11), 3113-3123, 2009 | 116 | 2009 |
| Global transcriptional response to CRISPR/Cas9-AAV6-based genome editing in CD34+ hematopoietic stem and progenitor cells MK Cromer, S Vaidyanathan, DE Ryan, B Curry, AB Lucas, J Camarena, ... Molecular Therapy 26 (10), 2431-2442, 2018 | 110 | 2018 |
| CRISPR-based gene editing enables FOXP3 gene repair in IPEX patient cells M Goodwin, E Lee, U Lakshmanan, S Shipp, L Froessl, F Barzaghi, ... Science advances 6 (19), eaaz0571, 2020 | 97 | 2020 |
| Reduced efficiency and increased mutagenicity of translesion DNA synthesis across a TT cyclobutane pyrimidine dimer, but not a TT 6-4 photoproduct, in human cells lacking DNA … A Hendel, O Ziv, Q Gueranger, N Geacintov, Z Livneh DNA repair 7 (10), 1636-1646, 2008 | 77 | 2008 |
| A comprehensive TALEN-based knockout library for generating human-induced pluripotent stem cell–based models for cardiovascular diseases I Karakikes, V Termglinchan, DA Cepeda, J Lee, S Diecke, A Hendel, ... Circulation Research 120 (10), 1561-1571, 2017 | 63 | 2017 |
| Repair of gaps opposite lesions by homologous recombination in mammalian cells S Adar, L Izhar, A Hendel, N Geacintov, Z Livneh Nucleic acids research 37 (17), 5737-5748, 2009 | 61 | 2009 |
| Using synthetically engineered guide RNAs to enhance CRISPR genome editing systems in mammalian cells D Allen, M Rosenberg, A Hendel Frontiers in Genome Editing 2, 617910, 2021 | 60 | 2021 |
| Increasing CRISPR efficiency and measuring its specificity in HSPCs using a clinically relevant system J Shapiro, O Iancu, AM Jacobi, MS McNeill, R Turk, GR Rettig, I Amit, ... Molecular Therapy Methods & Clinical Development 17, 1097-1107, 2020 | 52 | 2020 |
| The cell line A-to-I RNA editing catalogue AA Schaffer, E Kopel, A Hendel, E Picardi, EY Levanon, E Eisenberg Nucleic acids research 48 (11), 5849-5858, 2020 | 50 | 2020 |
| Single-stranded DNA-binding protein recruits DNA polymerase V to primer termini on RecA-coated DNA G Arad, A Hendel, C Urbanke, U Curth, Z Livneh Journal of biological chemistry 283 (13), 8274-8282, 2008 | 49 | 2008 |
| Ha-rasval12 induces HSP70b transcription via the HSE/HSF1 system, but HSP70b expression is suppressed in Ha-rasval12-transformed cells A Stanhill, V Levin, A Hendel, I Shachar, D Kazanov, N Arber, N Kaminski, ... Oncogene 25 (10), 1485-1495, 2006 | 33 | 2006 |
| Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients O Hassin, NB Nataraj, M Shreberk-Shaked, Y Aylon, R Yaeger, ... Nature communications 13 (1), 2800, 2022 | 29 | 2022 |
Rasmus O. BakAssociate Professor, PhD, Aarhus University, Dept. of BiomedicineVerified email at biomed.au.dk
