Christopher Cawthorne
Christopher Cawthorne
Senior Scientist, Preclinical PET
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Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and-independent mechanisms and contributes to drug resistance
JT Erler, CJ Cawthorne, KJ Williams, M Koritzinsky, BG Wouters, C Wilson, ...
Molecular and cellular biology 24 (7), 2875-2889, 2004
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters
R Boudewijns, HJ Thibaut, SJF Kaptein, R Li, V Vergote, L Seldeslachts, ...
Nature communications 11 (1), 1-10, 2020
Favipiravir at high doses has potent antiviral activity in SARS-CoV-2− infected hamsters, whereas hydroxychloroquine lacks activity
SJF Kaptein, S Jacobs, L Langendries, L Seldeslachts, S Ter Horst, ...
Proceedings of the National Academy of Sciences 117 (43), 26955-26965, 2020
A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate
L Sanchez-Felipe, T Vercruysse, S Sharma, J Ma, V Lemmens, ...
Nature 590 (7845), 320-325, 2021
Comparison of doxycycline delivery methods for Tet-inducible gene expression in a subcutaneous xenograft model
C Cawthorne, R Swindell, IJ Stratford, C Dive, A Welman
Journal of biomolecular techniques: JBT 18 (2), 120, 2007
[18F]DPA-714: Direct Comparison with [11C]PK11195 in a Model of Cerebral Ischemia in Rats
H Boutin, C Prenant, R Maroy, J Galea, AD Greenhalgh, A Smigova, ...
PloS one 8 (2), e56441, 2013
Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin-and Fas-induced apoptosis
GJ Griffiths, MY Koh, VG Brunton, C Cawthorne, NA Reeves, M Greaves, ...
Journal of Biological Chemistry 279 (44), 46113-46121, 2004
Multimodal nanoparticle imaging agents: design and applications
BP Burke, C Cawthorne, SJ Archibald
Philosophical Transactions of the Royal Society A: Mathematical, Physical …, 2017
Biodistribution, pharmacokinetics and metabolism of interleukin‐1 receptor antagonist (IL‐1RA) using [18F]‐IL1RA and PET imaging in rats
C Cawthorne, C Prenant, A Smigova, P Julyan, R Maroy, K Herholz, ...
British journal of pharmacology 162 (3), 659-672, 2011
Visualizing Kinetically Robust CoIII4L6 Assemblies in Vivo: SPECT Imaging of the Encapsulated [99mTc]TcO4 Anion
BP Burke, W Grantham, MJ Burke, GS Nichol, D Roberts, I Renard, ...
Journal of the American Chemical Society 140 (49), 16877-16881, 2018
Synthesis, characterization and in vivo evaluation of a magnetic cisplatin delivery nanosystem based on PMAA-graft-PEG copolymers
E Voulgari, A Bakandritsos, S Galtsidis, V Zoumpourlis, BP Burke, ...
Journal of Controlled Release 243, 342-356, 2016
Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions
BP Burke, N Baghdadi, AE Kownacka, S Nigam, GS Clemente, ...
Nanoscale 7 (36), 14889-14896, 2015
Imaging Cox‐2 expression in cancer using PET/SPECT radioligands: current status and future directions
A Pacelli, J Greenman, C Cawthorne, G Smith
Journal of Labelled Compounds and Radiopharmaceuticals 57 (4), 317-322, 2014
A caspase-3 ‘death-switch’in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell …
KL Simpson, C Cawthorne, C Zhou, CL Hodgkinson, MJ Walker, ...
Cell death & disease 4 (5), e613-e613, 2013
Implementation and validation of time-of-flight PET image reconstruction module for listmode and sinogram projection data in the STIR library
N Efthimiou, E Emond, P Wadhwa, C Cawthorne, C Tsoumpas, ...
Physics in Medicine & Biology 64 (3), 035004, 2019
Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells
S Nigam, BP Burke, LH Davies, J Domarkas, JF Wallis, PG Waddell, ...
Chemical Communications 52 (44), 7114-7117, 2016
New AMD3100 derivatives for CXCR4 chemokine receptor targeted molecular imaging studies: synthesis, anti-HIV-1 evaluation and binding affinities
S Poty, P Désogère, C Goze, F Boschetti, D Schols, C Cawthorne, ...
Dalton Transactions 44 (11), 5004-5016, 2015
Increases in c-Src expression level and activity do not promote the growth of human colorectal carcinoma cells in vitro and in vivo
A Welman, C Cawthome, L Ponce-Perez, J Barraclough, S Danson, ...
Neoplasia 8 (11), 905-IN2, 2006
Construction and characterization of multiple human colon cancer cell lines for inducibly regulated gene expression
A Welman, C Cawthorne, J Barraclough, N Smith, GJ Griffiths, RL Cowen, ...
Journal of cellular biochemistry 94 (6), 1148-1162, 2005
Development of PDT/PET Theranostics: Synthesis and Biological Evaluation of an 18F-Radiolabeled Water-Soluble Porphyrin
GM Entract, F Bryden, J Domarkas, H Savoie, L Allott, SJ Archibald, ...
Molecular Pharmaceutics 12 (12), 4414-4423, 2015
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