The KRAS oncogene product is considered a major target in anticancer drug discovery 1, 2,
3. However, direct interference with KRAS signalling has not yet led to clinically useful drugs
3, 4, 5, 6, 7, 8. Correct localization and signalling by farnesylated KRAS is regulated by the …

Reversible S-palmitoylation of cysteine residues critically controls transient membrane
tethering of peripheral membrane proteins. Little is known about how the palmitoylation
machinery governs their defined localization and function. We monitored the spatially …

We identify a role for the GDI-like solubilizing factor (GSF) PDEδ in modulating signalling
through Ras family G proteins by sustaining their dynamic distribution in cellular
membranes. We show that the GDI-like pocket of PDEδ binds and solubilizes farnesylated …

Abstract Lipidated Rho and Rab GTP-binding proteins are transported between membranes
in complex with solubilizing factors called'guanine nucleotide dissociation inhibitors'(GDIs).
Unloading from GDIs using GDI displacement factors (GDFs) has been proposed but …

Field experiments were conducted on a Typic Hapludoll (Mollisols) soil in the Indo-Gangetic
Plains of India during the 2008 and 2009 rainy seasons to (1) find out the effect of irrigation
schedules and plant spacing on physiological parameters, yield and water productivity of …

Objective: To develop diagnostic criteria for myxedema coma (MC), a decompensated state
of extreme hypothyroidism with a high mortality rate if untreated, in order to facilitate its early
recognition and treatment. Methods: The frequencies of characteristics associated with MC …

Purpose We present our results of and operative principles essential for a successful
outcome of complex posterior urethral disruption management. Materials and Methods A
total of 25 patients underwent abdominal transpubic perineal urethroplasty for complex …

A 2-year field experiment was conducted during the wet seasons (July–October) of 2008
and 2009 on a Typic Hapludoll Mollisol in Indo-Gangetic Plains Region (IGPR) to:(i)
investigate the effects of field water re-ponding intervals and plant spacing on the growth …

A field experiment was conducted on a Typic Hapludoll soil in Indo-gangetic plains of India
during the 2008 and 2009 rainy seasons to find out the effect of irrigation schedules and
plant spacing on yield, quality, nutrient uptake and economics of two rice (Oryza sativa L.) …

Kalmegh (Andrographis paniculata) has been widely exploited in traditional medicine for the
treatment of infectious diseases and health disorders. Ent-labdane-related diterpene (ent-
LRD) specialized (ie, secondary) metabolites of kalmegh such as andrographolide …