A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the
gold-standard analgesic morphine and other opiates. We found that hyperalgesia-inducing
treatment with morphine resulted in downregulation of the K+-Cl− co-transporter KCC2 …

Abstract The K+-Cl− cotransporter KCC2 is responsible for maintaining low Cl−
concentration in neurons of the central nervous system (CNS), which is essential for
postsynaptic inhibition through GABA A and glycine receptors. Although no CNS disorders …

The differential regulation of synaptic transmission by internal Ca 2+ stores of presynaptic
terminals and perisynaptic Schwann cells (PSCs) was studied at the frog neuromuscular
junction. Thapsigargin (tg), an inhibitor of Ca 2+-ATPase pumps of internal stores, caused a …

Reaction of the diphosphine ligand i-Pr2P (CH2) 5P (i-Pr) 2 with NiBr2 at 110° C gives a
mixture of the 16-membered bimetallacycle {i-Pr2P (CH2) 5P (i-Pr) 2} 2Ni2Br4, 1, and the
pincer-type complex {(i-Pr2PCH2CH2) 2CH} NiBr, 2; the latter can also be obtained by …

The cationic pincer-type complexes [{(i-Pr2PCH2CH2) 2CH} Ni (NCCH3)][BPh4](1),[{2, 6-(i-
Pr2PCH2) 2-C6H3} Ni (NCCH3)][BPh4](2),[{2, 6-(i-Pr2PO) 2-C6H3} Ni (NCCH3)][BPh4](3),
and [{2, 6-(i-Pr2PO) 2-3, 5-Cl2-C6H} Ni (NCCH3)][BPh4](6) have been prepared and fully …

Chloride homeostasis is a critical determinant of the strength and robustness of inhibition
mediated by GABAA receptors (GABAARs). The impact of changes in steady state Cl−
gradient is relatively straightforward to understand, but how dynamic interplay between Cl …

Heating Ni (II) halides with 1 equiv of But2P (CH2) 5PBut2 gives the PCsp3P pincer
complexes [{(But2P (CH2) 2) 2CH} NiX](X= Cl, 1a; Br, 1b; I, 1c). These compounds react with
MeMgCl or n-BuLi to give, respectively, the methyl species {(But2P (CH2) 2) 2CH} NiMe, 2 …

Novel ruthenium–letrozole complexes have been prepared, and cell viability of two human
cancer cell types (breast and glioblastoma) was determined. Some ruthenium compounds
are known for their cytotoxicity to cancer cells, whereas letrozole is an aromatase inhibitor …

Chronic pain attenuates midbrain dopamine (DA) transmission, as evidenced by a decrease
in opioid-evoked DA release in the ventral striatum, suggesting that the occurrence of
chronic pain impairs reward-related behaviors. However, mechanisms by which pain …

A divergent dendrimer construction methodology that employs CuI-catalysed alkyne–azide
cycloaddition (CuAAC) and furan–maleimide Diels–Alder (DA)“click” chemistry in a layer-by-
layer fashion, is described. This synergisitic approach yields dendrimers that undergo …