A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the
gold-standard analgesic morphine and other opiates. We found that hyperalgesia-inducing
treatment with morphine resulted in downregulation of the K+-Cl− co-transporter KCC2 …

By delivering optical images with spatial resolutions below the diffraction limit, several super-
resolution fluorescence microscopy techniques opened new opportunities to study
biological structures with details approaching molecular structure sizes. They have now …

Chloride homeostasis is a critical determinant of the strength and robustness of inhibition
mediated by GABAA receptors (GABAARs). The impact of changes in steady state Cl−
gradient is relatively straightforward to understand, but how dynamic interplay between Cl …

The subunit stoichiometry of heteromeric glycine-gated channels determines fundamental
properties of these key inhibitory neurotransmitter receptors; however, the ratio of α1-to β-
subunits per receptor remains controversial. We used single-molecule imaging and …

Measuring protein interactions is key to understanding cell signaling mechanisms, but
quantitative analysis of these interactions in situ has remained a major challenge. Here, we
present spatial intensity distribution analysis (SpIDA), an analysis technique for image data …

Cell signaling involves dynamic changes in protein oligomerization leading to the formation
of different signaling complexes and modulation of activity. Spatial intensity distribution
analysis (SpIDA) is an image analysis method that can directly measure oligomerization and …

The optical properties of core–shell CdSe–ZnS quantum dots (QDs) are characterized by
complex photophysics leading to difficulties in interpreting quantitative measurements based
on QD emission. By comparing the pH dependence of fluorescence of single QDs to that of …

Using single-nanotube absorption microscopy, we measured the absorption cross section of
(6, 5) carbon nanotubes at their second-order optical transition. We obtained a value of 3.2×
10–17 cm2/C atom with a precision of 15% and an accuracy below 20%. This constitutes the …

Endogenous acetylcholine is an important modulator of sensory processing, especially at
the spinal level, where nociceptive (pain‐related) stimuli enter the central nervous system
and are integrated before being relayed to the brain. To decipher the organization of the …

Here, we demonstrate a new approach for the design and assembly of a dynamic DNA cube
with an addressable cellular uptake profile. This cube can be selectively unzipped from a 3D
to a flat two-dimensional structure in the presence of a specific nucleic acid sequence …