User profiles for author:Bart author:Staels
 | Bart StaelsProfesseur Université Lille Verified email at pasteur-lille.fr Cited by 86414 |
[CITATION][C] Mechanism of action of fibrates on lipid and lipoprotein metabolism
Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression.
The three types of peroxisome proliferator-activated receptors (PPAR), termed alpha, delta
(or beta), and gamma, belong to the nuclear receptor superfamily. Although peroxisome
proliferators, including fibrates and fatty acids, activate the transcriptional activity of these …
(or beta), and gamma, belong to the nuclear receptor superfamily. Although peroxisome
proliferators, including fibrates and fatty acids, activate the transcriptional activity of these …
The organization, promoter analysis, and expression of the human PPARγ gene
PPARγ is a member of the PPAR subfamily of nuclear receptors. In this work, the structure of
the human PPARγ cDNA and gene was determined, and its promoters and tissue-specific
expression were functionally characterized. Similar to the mouse, two PPAR isoforms …
the human PPARγ cDNA and gene was determined, and its promoters and tissue-specific
expression were functionally characterized. Similar to the mouse, two PPAR isoforms …
Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators
Peroxisome proliferator-activated receptors (PPARs) are key players in lipid and glucose
metabolism and are implicated in metabolic disorders predisposing to atherosclerosis, such
as dyslipidaemia and diabetes 1. Whereas PPARγ promotes lipid storage by regulating …
metabolism and are implicated in metabolic disorders predisposing to atherosclerosis, such
as dyslipidaemia and diabetes 1. Whereas PPARγ promotes lipid storage by regulating …
Transient increase in obese gene expression after food intake or insulin administration
…, M Guerre-Millot, A Leturque, J Girard, B Staels… - Nature, 1995 - nature.com
OBESITY is a disorder of energy balance, indicating a chronic disequilibrium between
energy intake and expenditure 1. Recently, the mouse ob gene 2, and subsequently its
human and rat homologues 2-6, have been cloned. The ob gene product, leptin 7, is …
energy intake and expenditure 1. Recently, the mouse ob gene 2, and subsequently its
human and rat homologues 2-6, have been cloned. The ob gene product, leptin 7, is …
PPARalpha and PPARgamma activators direct a distinct tissue‐specific transcriptional response via a PPRE in the lipoprotein lipase gene.
…, RA Heyman, M Briggs, S Deeb, B Staels… - The EMBO …, 1996 - Wiley Online Library
Increased activity of lipoprotein lipase (LPL) may explain the hypotriglyceridemic effects of
fibrates, thiazolidinediones and fatty acids, which are known activators (and/or ligands) of
the various peroxisome proliferator‐activated receptors (PPARs). Treatment with …
fibrates, thiazolidinediones and fatty acids, which are known activators (and/or ligands) of
the various peroxisome proliferator‐activated receptors (PPARs). Treatment with …
PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway
…, HB Brewer, JC Fruchart, V Clavey, B Staels - Nature medicine, 2001 - nature.com
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that regulate lipid
and glucose metabolism and cellular differentiation. PPAR-α and PPAR-γ are both
expressed in human macrophages where they exert anti-inflammatory effects. The activation …
and glucose metabolism and cellular differentiation. PPAR-α and PPAR-γ are both
expressed in human macrophages where they exert anti-inflammatory effects. The activation …
The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation
This review addresses recent developments regarding the peroxisome proliferator activated
receptors (PPARs). We will briefly review the older literature regarding the phenomenon of
peroxisome proliferation and discuss the central role of PPAR in this process. Next, we will …
receptors (PPARs). We will briefly review the older literature regarding the phenomenon of
peroxisome proliferation and discuss the central role of PPAR in this process. Next, we will …
Peroxisome proliferator-activated receptor α negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-κB and …
…, JC Fruchart, A Tedgui, G Haegeman, B Staels - Journal of Biological …, 1999 - ASBMB
Abstract Interleukin-6 (IL-6) is a pleiotropic cytokine, whose plasma levels are elevated in
inflammatory diseases such as atherosclerosis. We have previously reported that
peroxisome proliferator-activated receptor α (PPARα) ligands (fibrates) lower elevated …
inflammatory diseases such as atherosclerosis. We have previously reported that
peroxisome proliferator-activated receptor α (PPARα) ligands (fibrates) lower elevated …
Activation of proliferator-activated receptors α and γ induces apoptosis of human monocyte-derived macrophages
…, JC Fruchart, J Chapman, J Najib, B Staels - Journal of Biological …, 1998 - ASBMB
Peroxisome proliferator-activated receptors (PPARs) have been implicated in metabolic
diseases, such as obesity, diabetes, and atherosclerosis, due to their activity in liver and
adipose tissue on genes involved in lipid and glucose homeostasis. Here, we show that the …
diseases, such as obesity, diabetes, and atherosclerosis, due to their activity in liver and
adipose tissue on genes involved in lipid and glucose homeostasis. Here, we show that the …
