The KRAS oncogene product is considered a major target in anticancer drug discovery 1, 2,
3. However, direct interference with KRAS signalling has not yet led to clinically useful drugs
3, 4, 5, 6, 7, 8. Correct localization and signalling by farnesylated KRAS is regulated by the …

KRas is a major proto-oncogene product whose signaling activity depends on its level of
enrichment on the plasma membrane (PM). This PM localization relies on posttranslational
prenylation for membrane affinity, while PM specificity has been attributed to electrostatic …

Precise quantification of endogenous protein–protein interactions across live cells would be
a major boon to biology. Such precise measurement is theoretically possible with
fluorescence lifetime imaging microscopy (FLIM) but requires first properly addressing …

The prenyl-binding protein PDEδ is crucial for the plasma membrane localization of
prenylated Ras. Recently, we have reported that the small-molecule Deltarasin binds to the
prenyl-binding pocket of PDEδ, and impairs Ras enrichment at the plasma membrane …

Bistatic synthetic aperture radar (SAR) enables high resolution imaging in forward direction
of a moving receiver, if the motion of the transmitter guarantees an adequate aspect angle
variation with respect to the scene center. Such a configuration could be realized at an …

Ras or “Rat sarcoma” is a central node in signal transduction networks that includes a range
of oncogenic proteins in its family. These small guanine nucleotide-binding proteins transmit
signals from lipid membranes in the cell with which they interact by an acquired affinity …