Electronics that are capable of intimate, non-invasive integration with the soft, curvilinear
surfaces of biological tissues offer important opportunities for diagnosing and treating
disease and for improving brain/machine interfaces. This article describes a material …

Arrays of electrodes for recording and stimulating the brain are used throughout clinical
medicine and basic neuroscience research, yet are unable to sample large areas of the
brain while maintaining high spatial resolution because of the need to individually wire each …

Mechanisms underlying seizure generation are traditionally thought to act over seconds to
minutes before clinical seizure onset. We analyzed continuous 3-to 14-day intracranial EEG
recordings from five patients with mesial temporal lobe epilepsy obtained during evaluation …

Developing advanced surgical tools for minimally invasive procedures represents an activity
of central importance to improving human health. A key challenge is in establishing
biocompatible interfaces between the classes of semiconductor device and sensor …

Neocortical seizures are often poorly localized, explosive and widespread at onset, making
them poorly amenable to epilepsy surgery in the absence of associated focal brain lesions.
We describe, for the first time in an unselected group of patients with neocortical epilepsy …

For almost 40 years, neuroscientists thought that epileptic seizures began abruptly, just a
few seconds before clinical attacks. There is now mounting evidence that seizures develop
minutes to hours before clinical onset. This change in thinking is based on quantitative …

Purpose: Animal studies and sporadic case reports in human subjects have suggested that
intermittent electrical stimulation of the anterior nucleus of the thalamus reduces seizure
activity. We embarked on an open‐label pilot study to determine initial safety and tolerability …

Neuronal oscillations span a wide range of spatial and temporal scales that extend beyond
traditional clinical EEG. Recent research suggests that high-frequency oscillations (HFO), in
the ripple (80–250 Hz) and fast ripple (250–1000 Hz) frequency range, may be signatures of …

The fractal dimension of a waveform represents a powerful tool for transient detection. In
particular, in analysis of electroencephalograms and electrocardiograms, this feature has
been used to identify and distinguish specific states of physiologic function. A variety of …

A method and apparatus for forecasting and controlling neurological abnormalities in
humans such as seizures or other brain disturbances. The system is based on a multi-level
control strategy. Using as inputs one or more types of physiological measures such as brain …