Cytoplasmic dynein and kinesin-1 are microtubule-based motors with opposite polarity that
transport a wide variety of cargo in eukaryotic cells. Many cellular cargos demonstrate
bidirectional movement due to the presence of ensembles of dynein and kinesin, but are …

Processivity, the ability of single molecules to move continuously along a track, is a
fundamental requirement of cargo-transporting molecular motors. Here, we investigate how
cytoplasmic dynein, a homodimeric, microtubule-based motor, achieves processive motion …

Background Patients with a myocardial infarction with ST-segment elevation who present to
hospitals that do not have the capability of performing percutaneous coronary intervention
(PCI) often cannot undergo timely primary PCI and therefore receive fibrinolysis. The role …

We conducted a large-scale screen for Drosophila mutants that have structural
abnormalities of the larval neuromuscular junction (NMJ). We recovered mutations in wishful
thinking (wit), a gene that positively regulates synaptic growth. wit encodes a BMP type II …

We show that the BMP ortholog Gbb can signal by a retrograde mechanism to regulate
synapse growth of the Drosophila neuromuscular junction (NMJ). gbb mutants have a
reduced NMJ synapse size, decreased neurotransmitter release, and aberrant presynaptic …

Background Andexanet alfa (andexanet) is a recombinant modified human factor Xa decoy
protein that has been shown to reverse the inhibition of factor Xa in healthy volunteers.
Methods In this multicenter, prospective, open-label, single-group study, we evaluated 67 …

Highwire (Hiw), a putative RING finger E3 ubiquitin ligase, negatively regulates synaptic
growth at the neuromuscular junction (NMJ) in Drosophila. hiw mutants have dramatically
larger synaptic size and increased numbers of synaptic boutons. Here we show that Hiw …

Rationale Use of etomidate in the critically ill is controversial due to its links with an
inadequate response to corticotropin and potential for excess mortality. In a septic shock
population, we tested the hypotheses that etomidate administration induces more non …

Integrins are αβ heterodimeric cell surface receptors that mediate transmembrane signaling
by binding extracellular and cytoplasmic ligands. The ectodomain of integrin αVβ3
crystallizes in a bent, genuflexed conformation considered to be inactive (unable to bind …

Background The Global Registry of Acute Coronary Events (GRACE)—a prospective,
multinational study of patients hospitalized with acute coronary syndromes (ACSs)—was
designed to improve the quality of care for patients with an ACS. Expanded GRACE aims to …