Mammalian pre-implantation development is a complex process involving dramatic changes
in the transcriptional architecture 1, 2, 3, 4. We report here a comprehensive analysis of
transcriptome dynamics from oocyte to morula in both human and mouse embryos, using …

Genomic and other high dimensional analyses often require one to summarize multiple
related variables by a single representative. This task is also variously referred to as
collapsing, combining, reducing, or aggregating variables. Examples include summarizing …

Copy-number variants (CNVs) are a major contributor to the pathophysiology of autism
spectrum disorders (ASDs), but the functional impact of CNVs remains largely unexplored.
Because brain tissue is not available from most samples, we interrogated gene expression …

Symptoms of Major Depressive Disorder (MDD) are hypothesized to arise from dysfunction
in brain networks linking the limbic system and cortical regions. Alterations in brain
functional cortical connectivity in resting-state networks have been detected with functional …

Since human brain tissue is often unavailable for transcriptional profiling studies, blood
expression data is frequently used as a substitute. The underlying hypothesis in such
studies is that genes expressed in brain tissue leave a transcriptional footprint in blood. We …

It has been debated whether human induced pluripotent stem cells (iPSCs) and embryonic
stem cells (ESCs) express distinctive transcriptomes. By using the method of weighted gene
co-expression network analysis, we showed here that iPSCs exhibit altered functional …

Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease with complex
etiopathogenesis. Despite extensive studies to understand the disease process utilizing
human and mouse models, the intersection between these species remains elusive. To …

To provide a detailed analysis of the molecular components and underlying mechanisms
associated with ovarian cancer, we performed a comprehensive mass-spectrometry-based
proteomic characterization of 174 ovarian tumors previously analyzed by The Cancer …

Protocatechuic acid (PCA) is a major metabolite of anthocyanins. It has numerous
pharmacological effects, including anti-inflammatory, antioxidant, and antitumoral activities.
In the present study, we investigated the in vivo protective effect of PCA on acute lung injury …

Objectives To evaluate alterations of the intestinal bacteria and its associations with the
inflammation in acute pancreatitis (AP). Methods A multihospital prospective clinical study
was conducted, and a total of 108 participants were enrolled in our study, including 44 with …