Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy
…, S Lancel, J Eeckhoute, MKC Hesselink, C Paquet… - Nature medicine, 2013 - nature.com
The nuclear receptor Rev-erb-α modulates hepatic lipid and glucose metabolism,
adipogenesis and the inflammatory response in macrophages. We show here that Rev-erb-
α is highly expressed in oxidative skeletal muscle and that its deficiency in muscle leads to …
adipogenesis and the inflammatory response in macrophages. We show here that Rev-erb-
α is highly expressed in oxidative skeletal muscle and that its deficiency in muscle leads to …
p16INK4a-deficiency promotes IL-4–induced polarization and inhibits pro-inflammatory signaling in macrophages
The CDKN2A locus, which contains the tumor suppressor gene p16 INK4a, is associated
with an increased risk of age-related inflammatory diseases, such as cardiovascular disease
and type 2 diabetes, in which macrophages play a crucial role. Monocytes can polarize …
with an increased risk of age-related inflammatory diseases, such as cardiovascular disease
and type 2 diabetes, in which macrophages play a crucial role. Monocytes can polarize …
The novel selective PPARα modulator (SPPARMα) pemafibrate improves dyslipidemia, enhances reverse cholesterol transport and decreases inflammation and …
N Hennuyer, I Duplan, C Paquet, J Vanhoutte… - Atherosclerosis, 2016 - Elsevier
Background Atherosclerosis is characterized by lipid accumulation and chronic inflammation
in the arterial wall. Elevated levels of apolipoprotein (apo) B-containing lipoproteins are a
risk factor for cardiovascular disease (CVD). By contrast, plasma levels of functional high …
in the arterial wall. Elevated levels of apolipoprotein (apo) B-containing lipoproteins are a
risk factor for cardiovascular disease (CVD). By contrast, plasma levels of functional high …
[HTML][HTML] Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice
…, E Woitrain, M Gauriot, C Paquet… - Nature …, 2015 - nature.com
Insulin-degrading enzyme (IDE) is a protease that cleaves insulin and other bioactive
peptides such as amyloid-β. Knockout and genetic studies have linked IDE to Alzheimer's
disease and type-2 diabetes. As the major insulin-degrading protease, IDE is a candidate …
peptides such as amyloid-β. Knockout and genetic studies have linked IDE to Alzheimer's
disease and type-2 diabetes. As the major insulin-degrading protease, IDE is a candidate …
[HTML][HTML] Bone marrow p16INK4a-deficiency does not modulate obesity, glucose homeostasis or atherosclerosis development
…, K Bantubungi, J Vanhoutte, R Dièvart, C Paquet… - PloS one, 2012 - journals.plos.org
Objective A genomic region near the CDKN2A locus, encoding p16INK4a, has been
associated to type 2 diabetes and atherosclerotic vascular disease, conditions in which
inflammation plays an important role. Recently, we found that deficiency of p16INK4a results …
associated to type 2 diabetes and atherosclerotic vascular disease, conditions in which
inflammation plays an important role. Recently, we found that deficiency of p16INK4a results …
[HTML][HTML] Semi-synthesis of a HGF/SF kringle one (K1) domain scaffold generates a potent in vivo MET receptor agonist
…, B Leclercq, A Mougel, E Adriaenssens, C Paquet… - Chemical …, 2015 - pubs.rsc.org
The development of MET receptor agonists is an important goal in regenerative medicine,
but is limited by the complexity and incomplete understanding of its interaction with HGF/SF
(Hepatocyte Growth Factor/Scatter Factor). NK1 is a natural occurring agonist comprising the …
but is limited by the complexity and incomplete understanding of its interaction with HGF/SF
(Hepatocyte Growth Factor/Scatter Factor). NK1 is a natural occurring agonist comprising the …
[BOOK][B] Taiwan: le prix de la réussite
R Dumont, C Paquet - 1986 - books.google.com
Face aux innombrables échecs des divers socialismes—de l'URSS à l'Éthiopie, en passant
par Cuba et le Viêt Nam—et face aux faillites économiques de la plupart des États du tiers
monde, le succès de Taïwan ne pouvait laisser insensible René Dumont. Avec sa …
par Cuba et le Viêt Nam—et face aux faillites économiques de la plupart des États du tiers
monde, le succès de Taïwan ne pouvait laisser insensible René Dumont. Avec sa …
[CITATION][C] Um Mundo intoleravel o liberalismo em questão
R Dumont, C Paquet - 1989 - sidalc.net
SIDALC.
Performance and complications of lumbar puncture in memory clinics: results of the multicenter lumbar puncture feasibility study
FH Duits, P Martinez-Lage, C Paquet… - Alzheimer's & …, 2016 - Elsevier
Introduction Lumbar puncture (LP) is increasingly performed in memory clinics. We
investigated patient-acceptance of LP, incidence of and risk factors for post-LP
complications in memory clinic populations. Methods We prospectively enrolled 3868 …
investigated patient-acceptance of LP, incidence of and risk factors for post-LP
complications in memory clinic populations. Methods We prospectively enrolled 3868 …
[CITATION][C] Démocratie pour l'Afrique: la longue marche de l'Afrique noire vers la liberté
R Dumont, C Paquet - 1991 - Seuil
