Lentivector‐mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia
T Torashima, C Koyama, A Iizuka, K Mitsumura… - EMBO …, 2008 - embor.embopress.org
Polyglutamine disorders are inherited neurodegenerative diseases caused by the
accumulation of expanded polyglutamine protein (polyQ). Previously, we identified a new
guanosine triphosphatase, CRAG, which facilitates the degradation of polyQ aggregates …
accumulation of expanded polyglutamine protein (polyQ). Previously, we identified a new
guanosine triphosphatase, CRAG, which facilitates the degradation of polyQ aggregates …
High transgene expression by lentiviral vectors causes maldevelopment of Purkinje cells in vivo
…, A Iizuka, K Takayama, AN Shuvaev, C Koyama… - The Cerebellum, 2010 - Springer
Lentiviral vectors are promising as gene-transfer vehicles for gene therapy targeted to
intractable brain diseases. Although lentiviral vectors are thought to exert little toxicity on
infected cells, the adverse influence of viral infection on vulnerable developing neurons has …
intractable brain diseases. Although lentiviral vectors are thought to exert little toxicity on
infected cells, the adverse influence of viral infection on vulnerable developing neurons has …
[HTML][HTML] The X-ray observatory Suzaku
…, M Bautz, H Inoue, RL Kelley, K Koyama… - Publications of the …, 2007 - academic.oup.com
High-sensitivity wide-band X-ray spectroscopy is the key feature of the Suzaku X-ray
observatory, launched on 2005 July 10. This paper summarizes the spacecraft, in-orbit
performance, operations, and data processing that are related to observations. The scientific …
observatory, launched on 2005 July 10. This paper summarizes the spacecraft, in-orbit
performance, operations, and data processing that are related to observations. The scientific …
Rescue of abnormal phenotypes in δ2 glutamate receptor‐deficient mice by the extracellular N‐terminal and intracellular C‐terminal domains of the δ2 glutamate …
…, K Mitsumura, M Yamasaki, C Koyama… - European Journal of …, 2009 - Wiley Online Library
The δ2 glutamate receptor (GluRδ2) is expressed predominantly in cerebellar Purkinje cells.
GluRδ2 knock‐out mice show impaired synaptogenesis and loss of long‐term depression
(LTD) at parallel fiber/Purkinje cell synapses, and persistent multiple climbing fiber (CF) …
GluRδ2 knock‐out mice show impaired synaptogenesis and loss of long‐term depression
(LTD) at parallel fiber/Purkinje cell synapses, and persistent multiple climbing fiber (CF) …
Lentiviral vector-mediated rescue of motor behavior in spontaneously occurring hereditary ataxic mice
…, T Torashima, M Yamasaki, C Koyama… - Neurobiology of …, 2009 - Elsevier
Hotfoot5J mice are spontaneously occurring ataxic mice that lack δ2 glutamate receptor
(GluRδ2) protein in cerebellar Purkinje cells. Here we aimed to rescue the ataxic phenotype
of hotfoot5J mice by lentiviral vector-mediated expression of recombinant GluRδ2 in …
(GluRδ2) protein in cerebellar Purkinje cells. Here we aimed to rescue the ataxic phenotype
of hotfoot5J mice by lentiviral vector-mediated expression of recombinant GluRδ2 in …
Characterization of mutant mice that express polyglutamine in cerebellar Purkinje cells
M Oue, K Mitsumura, T Torashima, C Koyama… - Brain research, 2009 - Elsevier
We recently produced transgenic mice that expressed an abnormally expanded
polyglutamine (polyQ) specifically in cerebellar Purkinje cells (polyQ mice). The polyQ mice
showed inclusion body formation, cerebellar atrophy and severe ataxia. Here we analyzed …
polyglutamine (polyQ) specifically in cerebellar Purkinje cells (polyQ mice). The polyQ mice
showed inclusion body formation, cerebellar atrophy and severe ataxia. Here we analyzed …
Free radical scavenging and hepatoprotective actions of the medicinal herb, Crassocephalum crepidioides from the Okinawa Islands
Y Aniya, T Koyama, C Miyagi, M Miyahira… - Biological and …, 2005 - jstage.jst.go.jp
MATERIALS AND METHODS Chemicals Reduced glutathione (GSH), glucose 6-phosphate,
and lipopolysaccharide (Salmonella enteritidis) were obtained from Sigma Chemicals (St.
Louis, MO, USA). D-Galactosamine (GalN) was obtained from Nacalai Tesque (Kyoto). 1 …
and lipopolysaccharide (Salmonella enteritidis) were obtained from Sigma Chemicals (St.
Louis, MO, USA). D-Galactosamine (GalN) was obtained from Nacalai Tesque (Kyoto). 1 …
Separation of selenium-containing proteins in human and mouse plasma using tandem high-performance liquid chromatography columns coupled with inductively …
H Koyama, K Omura, A Ejima, Y Kasanuma… - Analytical …, 1999 - Elsevier
An analytical method that uses two different high-performance liquid chromatography
(HPLC) columns in tandem has been developed that separates three major selenium-
containing proteins (albumin, glutathione peroxidase, and selenoprotein P) found in human …
(HPLC) columns in tandem has been developed that separates three major selenium-
containing proteins (albumin, glutathione peroxidase, and selenoprotein P) found in human …
MDR1 haplotype frequencies in Japanese and Caucasian, and in Japanese patients with colorectal cancer and esophageal cancer
…, DL Kroetz, T Yamada, H Omatsu, T Koyama… - Drug metabolism and …, 2006 - Elsevier
The genotype frequencies of MDR1 T-129C, C1236T, G2677A, T and C3435T SNPs were
compared in 154 healthy Japanese and 100 healthy Caucasians to provide basic
information on the interethnic differences of pharmacotherapeutic outcome. The variants …
compared in 154 healthy Japanese and 100 healthy Caucasians to provide basic
information on the interethnic differences of pharmacotherapeutic outcome. The variants …
STIR turbo SE MR imaging vs. coregistered FDG‐PET/CT: Quantitative and qualitative assessment of N‐stage in non‐small‐cell lung cancer patients
Y Ohno, H Koyama, M Nogami… - Journal of Magnetic …, 2007 - Wiley Online Library
Purpose To conduct a prospective comparison of the accuracy of short inversion time (TI)
inversion‐recovery (STIR) turbo spin‐echo (SE) imaging and coregistered 2‐[fluorine‐18]
fluoro‐2‐deoxy‐D‐glucose (FDG)–positron emission tomography (PET) with computed …
inversion‐recovery (STIR) turbo spin‐echo (SE) imaging and coregistered 2‐[fluorine‐18]
fluoro‐2‐deoxy‐D‐glucose (FDG)–positron emission tomography (PET) with computed …
