Statins are inhibitors of 3-hydroxy-3-methylglutaryl–coenzyme A (HMG-CoA) reductase used
in the prevention of cardiovascular disease (CVD). In addition to their cholesterol-lowering
activities, statins exert pleiotropic antiinflammatory effects, which might contribute to their …

The nuclear receptor Rev-erb-α modulates hepatic lipid and glucose metabolism,
adipogenesis and the inflammatory response in macrophages. We show here that Rev-erb-
α is highly expressed in oxidative skeletal muscle and that its deficiency in muscle leads to …

Peroxisome proliferator-activated receptor (PPAR) α and γ are ligand-activated transcription
factors belonging to the nuclear receptor family. PPARα mediates the hypolipidemic action
of the fibrates, whereas PPARγ is a receptor for the antidiabetic glitazones. In the present …

Background & Aims: Conversion into bile acids represents an important route to remove
excess cholesterol from the body. Rev-erbα is a nuclear receptor that participates as one of
the clock genes in the control of circadian rhythmicity and plays a regulatory role in lipid …

Background: Resveratrol (a naturally occurring phytoalexin found in grapes and wine) has
cardiovascular protective effects that suggest the antiatherogenic (ie, antiinflammatory)
activities of the compound on endothelial cells. Objective: The antiinflammatory activity of …

Purpose. The objective of this work was to assess, in vitro, the passage of P-glycoprotein
dependent drugs across brain capillary endothelial cells, when these drugs are associated
with a reversing agent. Methods. An in vitro model of the blood-brain barrier consisting of a …

Objective—The newly identified apolipoprotein A5 (APOA5), selectively expressed in the
liver, is a crucial determinant of plasma triglyceride levels. Because elevated plasma
triglyceride concentrations constitute an independent risk factor for cardiovascular diseases …

The bile acid receptor Farnesoid X Receptor (FXR) is expressed in adipose tissue, but its
function remains poorly defined. Peroxisome proliferator-activated receptor-γ (PPARγ) is a
master regulator of adipocyte differentiation and function. The aim of this study was to …

A role of the nuclear receptor Rev-erbα in the regulation of transcription pathways involving
other nuclear receptors is emerging. Indeed, Rev-erbα is a negative regulator of
transcription by binding to overlapping response elements shared with various nuclear …

We have developed two methods for measuring the alpha-tocopherol content in plasma and
lipoproteins (LDL and HDL). In procedure 1, plasma or lipoproteins are deproteinized with
ethanol containing delta-tocopherol as internal standard and then extracted with hexane or …