● Pathological Q waves with or without symptoms in the absence of non-ischemic
causes.● Imaging evidence of a region of loss of viable myocardium that is thinned and fails
to contract, in the absence of a non-ischemic cause.● Pathological findings of a prior MI.

Genomic analysis provides insights into the role of copy number variation in disease, but
most methods are not designed to resolve mixed populations of cells. In tumours, where
genetic heterogeneity is common 1, 2, 3, very important information may be lost that would …

Exome sequencing of 343 families, each with a single child on the autism spectrum and at
least one unaffected sibling, reveal de novo small indels and point substitutions, which come
mostly from the paternal line in an age-dependent manner. We do not see significantly …

Whole exome sequencing has proven to be a powerful tool for understanding the genetic
architecture of human disease. Here we apply it to more than 2,500 simplex families, each
having a child with an autistic spectrum disorder. By comparing affected to unaffected …

To explore the genetic contribution to autistic spectrum disorders (ASDs), we have studied
genomic copy-number variation in a large cohort of families with a single affected child and
at least one unaffected sibling. We confirm a major contribution from de novo deletions and …

Identification of complex molecular networks underlying common human phenotypes is a
major challenge of modern genetics. In this study, we develop a method for network-based
analysis of genetic associations (NETBAG). We use NETBAG to identify a large biological …

Cancer progression in humans is difficult to infer because we do not routinely sample
patients at multiple stages of their disease. However, heterogeneous breast tumors provide
a unique opportunity to study human tumor progression because they still contain evidence …

Hybridization with oligonucleotide microchips (microarrays) was used for discrimination
among strains of Escherichia coli and other pathogenic enteric bacteria harboring various
virulence factors. Oligonucleotide microchips are miniature arrays of gene-specific …

To assess nonexperimental (NX) evaluation methods in the context of welfare, job training,
and employment services programs, the authors reexamined the results of twelve case
studies intended to replicate impact estimates from an experimental evaluation by using NX …

As an alternative to standard gene transfer techniques for genetic manipulation, we have
investigated the use of triple helix-forming oligonucleotides to target mutations to selected
genes within mammalian cells. By treating monkey COS cells with oligonucleotides linked to …