Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl− homeostasis
A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the
gold-standard analgesic morphine and other opiates. We found that hyperalgesia-inducing
treatment with morphine resulted in downregulation of the K+-Cl− co-transporter KCC2 …
gold-standard analgesic morphine and other opiates. We found that hyperalgesia-inducing
treatment with morphine resulted in downregulation of the K+-Cl− co-transporter KCC2 …
[HTML][HTML] The price of tumor control: an analysis of rare side effects of anti-CTLA-4 therapy in metastatic melanoma from the ipilimumab network
…, A Justich, U Keller, C Klein, C Mateus, P Mohr… - PloS one, 2013 - journals.plos.org
Background Ipilimumab, a cytotoxic T-lymphocyte antigen-4 (CTLA-4) blocking antibody,
has been approved for the treatment of metastatic melanoma and induces adverse events
(AE) in up to 64% of patients. Treatment algorithms for the management of common …
has been approved for the treatment of metastatic melanoma and induces adverse events
(AE) in up to 64% of patients. Treatment algorithms for the management of common …
Helicobacter pylori infection: a risk factor for upper gastrointestinal bleeding after cardiac surgery?
U Halm, F Halm, D Thein, FW Mohr… - Critical care …, 2000 - journals.lww.com
Objective: To determine the prevalence of Helicobacter pylori (H. pylori) in critically ill
patients who develop upper gastrointestinal bleeding after cardiac surgery in relation to
other risk factors. Design: Prospective, single center, cohort study. Setting: Surgical intensive …
patients who develop upper gastrointestinal bleeding after cardiac surgery in relation to
other risk factors. Design: Prospective, single center, cohort study. Setting: Surgical intensive …
Up‐regulation of the fibroblast growth factor 8 subfamily in human hepatocellular carcinoma for cell survival and neoangiogenesis
…, C Fischer, C Rodgarkia‐Dara, T Mohr… - …, 2011 - Wiley Online Library
Fibroblast growth factors (FGFs) and their high‐affinity receptors [fibroblast growth factor
receptors (FGFRs)] contribute to autocrine and paracrine growth stimulation in several
nonliver cancer entities. Here we report that at least one member of the FGF8 subfamily …
receptors (FGFRs)] contribute to autocrine and paracrine growth stimulation in several
nonliver cancer entities. Here we report that at least one member of the FGF8 subfamily …
[HTML][HTML] The experimental power of FR900359 to study Gq-regulated biological processes
…, SA Laporte, J Aoki, BK Fleischmann, K Mohr… - Nature …, 2015 - nature.com
Despite the discovery of heterotrimeric αβγ G proteins∼ 25 years ago, their selective
perturbation by cell-permeable inhibitors remains a fundamental challenge. Here we report
that the plant-derived depsipeptide FR900359 (FR) is ideally suited to this task. Using a …
perturbation by cell-permeable inhibitors remains a fundamental challenge. Here we report
that the plant-derived depsipeptide FR900359 (FR) is ideally suited to this task. Using a …
Accumbal dopamine D2 receptors are important for sensorimotor gating in C3H mice
D Mohr, PKD Pilz, CF Plappert, M Fendt - Neuroreport, 2007 - journals.lww.com
Quinpirole infusions increased PPI and attenuated prepulse facilitation, whereas
dihydrexidine had no e¡ ects. These results stand in contrast to data after systemic injections
in mice and rats and intra-accumbal infusions in rats, suggesting that the role of dopamine …
dihydrexidine had no e¡ ects. These results stand in contrast to data after systemic injections
in mice and rats and intra-accumbal infusions in rats, suggesting that the role of dopamine …
5, 7-dihydroxytryptamine injections into the prefrontal cortex and nucleus accumbens differently affect prepulse inhibition and baseline startle magnitude in rats
D Mohr, A von Ameln-Mayerhofer, M Fendt - Behavioural brain research, 2009 - Elsevier
The prefrontal cortex and the nucleus accumbens are two brain sites which are known to be
involved in the modulation of the acoustic startle response. In particular, the release of
monoaminergic transmitters within these brain sites plays an important role in prepulse …
involved in the modulation of the acoustic startle response. In particular, the release of
monoaminergic transmitters within these brain sites plays an important role in prepulse …
[CITATION][C] Das nomadische Subjekt
D Mohr - Ich-Entgrenzung in der Prosa Robert Walsers. Frankfurt …, 1994
redMaGiC: selecting luminous red galaxies from the DES Science Verification data
We introduce redMaGiC, an automated algorithm for selecting luminous red galaxies
(LRGs). The algorithm was specifically developed to minimize photometric redshift
uncertainties in photometric large-scale structure studies. redMaGiC achieves this by self …
(LRGs). The algorithm was specifically developed to minimize photometric redshift
uncertainties in photometric large-scale structure studies. redMaGiC achieves this by self …
[HTML][HTML] Prognostic quality of activating TERT promoter mutations in glioblastoma: interaction with the rs2853669 polymorphism and patient age at diagnosis
…, D Lötsch, B Ghanim, C Pirker, T Mohr… - Neuro …, 2015 - academic.oup.com
Background Expression of the telomerase reverse transcriptase (TERT) might be altered by
activating mutations of the rs2853669 polymorphism within the promoter region. Here we
investigate the impact of these genomic alterations on telomerase activation and dissect …
activating mutations of the rs2853669 polymorphism within the promoter region. Here we
investigate the impact of these genomic alterations on telomerase activation and dissect …
