Systemic lupus erythematosus (SLE) is a complex, inflammatory autoimmune disease that
affects multiple organ systems. We used global gene expression profiling of peripheral
blood mononuclear cells to identify distinct patterns of gene expression that distinguish most …

We genotyped 525 independent North American white individuals with systemic lupus
erythematosus (SLE) for the PTPN22 R620W polymorphism and compared the results with
data generated from 1,961 white control individuals. The R620W SNP was associated with …

Genome-wide association studies have recently identified at least 15 susceptibility loci for
systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from
2,466 regions that showed nominal evidence of association to SLE (P< 0.05) in a genome …

Systemic lupus erythematosus (SLE) is a complex autoimmune disease 1 characterized by
activation of the type I interferon (IFN) pathway 2, 3, 4. Here we convincingly replicate
association of the IFN regulatory factor 5 (IRF5) rs2004640 T allele with SLE 5 in four …

Systematic genome-wide studies to map genomic regions associated with human diseases
are becoming more practical. Increasingly, efforts will be focused on the identification of the
specific functional variants responsible for the disease. The challenges of identifying causal …

Recent studies of patients with systemic lupus erythematosus, together with data from lupus-
prone mice, suggest that inappropriate activation of type I interferon might have a role in
disease pathogenesis. Serum levels of IFN-α are elevated in SLE patients, and gene …

Background Systemic lupus erythematosus (SLE) is a serious systemic autoimmune
disorder that affects multiple organ systems and is characterized by unpredictable flares of
disease. Recent evidence indicates a role for type I interferon (IFN) in SLE pathogenesis; …

Human leukocyte antigen (HLA) class I and class II alleles are implicated as genetic risk
factors for many autoimmune diseases. However, the role of the HLA loci in human systemic
lupus erythematosus (SLE) remains unclear. Using a dense map of polymorphic …

Objective Systemic lupus erythematosus (SLE) is a complex autoimmune disease
characterized by unpredictable flares of disease activity and irreversible damage to multiple
organ systems. An earlier study showed that SLE patients carrying an interferon (IFN) gene …

Sjögren's syndrome (SS) is a common chronic autoimmune disease characterized by
lymphocytic infiltration of exocrine glands. The affected cases commonly present with oral
and ocular dryness, which is thought to be the result of inflammatory cell-mediated gland …