The LDL receptor‐related protein (LRP) family: an old family of proteins with new physiological functions
P May, E Woldt, RL Matz, P Boucher - Annals of medicine, 2007 - Taylor & Francis
The low‐density lipoprotein (LDL) receptor is the founding member of a family of seven
structurally closely related transmembrane proteins (LRP1, LRP1b, megalin/LRP2, LDL
receptor, very low‐density lipoprotein receptor, MEGF7/LRP4, LRP8/apolipoprotein E …
structurally closely related transmembrane proteins (LRP1, LRP1b, megalin/LRP2, LDL
receptor, very low‐density lipoprotein receptor, MEGF7/LRP4, LRP8/apolipoprotein E …
Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy
E Woldt, Y Sebti, LA Solt, C Duhem, S Lancel… - Nature medicine, 2013 - nature.com
The nuclear receptor Rev-erb-α modulates hepatic lipid and glucose metabolism,
adipogenesis and the inflammatory response in macrophages. We show here that Rev-erb-
α is highly expressed in oxidative skeletal muscle and that its deficiency in muscle leads to …
adipogenesis and the inflammatory response in macrophages. We show here that Rev-erb-
α is highly expressed in oxidative skeletal muscle and that its deficiency in muscle leads to …
LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling
…, K Zurhove, P Haffner, C Philippe, E Woldt… - Journal of Biological …, 2009 - ASBMB
The low-density lipoprotein receptor-related protein LRP1 is a cell surface receptor with
functions in diverse physiological pathways, including lipid metabolism. Here we show that
LRP1-deficient fibroblasts accumulate high levels of intracellular cholesterol and cholesteryl …
functions in diverse physiological pathways, including lipid metabolism. Here we show that
LRP1-deficient fibroblasts accumulate high levels of intracellular cholesterol and cholesteryl …
[HTML][HTML] The nuclear hormone receptor PPARγ counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells
E Woldt, J Terrand, M Mlih, RL Matz, V Bruban… - Nature …, 2012 - nature.com
Vascular calcification is a hallmark of advanced atherosclerosis. Here we show that deletion
of the nuclear receptor PPARγ in vascular smooth muscle cells of low density lipoprotein
receptor (LDLr)-deficient mice fed an atherogenic diet high in cholesterol, accelerates …
of the nuclear receptor PPARγ in vascular smooth muscle cells of low density lipoprotein
receptor (LDLr)-deficient mice fed an atherogenic diet high in cholesterol, accelerates …
Differential signaling by adaptor molecules LRP1-SHCA regulates adipogenesis by the insulin-like growth factor-1 receptor
E Woldt, RL Matz, J Terrand, M Mlih, C Gracia… - Journal of Biological …, 2011 - ASBMB
The Low-density lipoprotein receptor-related protein (LRP1) is a transmembrane receptor
that integrates multiple signaling pathways. Its cytoplasmic domain serves as docking sites
for several adaptor proteins such as the Src homology 2/α-collagen (ShcA), which also binds …
that integrates multiple signaling pathways. Its cytoplasmic domain serves as docking sites
for several adaptor proteins such as the Src homology 2/α-collagen (ShcA), which also binds …
Atherosclerosis severity is not affected by a deficiency in IL‐33/ST2 signaling
…, G Palmer, E Rodriguez, E Woldt… - Immunity …, 2015 - Wiley Online Library
Abstract Interleukin (IL)‐33 is a cytokine of the IL‐1 family, which signals through the ST2
receptor. Previous work demonstrated that the systemic administration of recombinant IL‐33
reduces the development of atherosclerosis in apolipoprotein E‐deficient (ApoE−/−) mice by …
receptor. Previous work demonstrated that the systemic administration of recombinant IL‐33
reduces the development of atherosclerosis in apolipoprotein E‐deficient (ApoE−/−) mice by …
IL-36–induced toxicity in neonatal mice involves TNF-α production by liver myeloid cells
J Palomo, B Mastelic-Gavillet, E Woldt… - The Journal of …, 2016 - Am Assoc Immnol
Human and mouse neonates exhibit limited vaccine responses characterized by
predominant Th2 and limited Th1 responses. Because IL-36 exerts a synergic adjuvant
effect with IL-12, enhancing Th1 polarization in adult (AD) mice, we administered IL-36β to …
predominant Th2 and limited Th1 responses. Because IL-36 exerts a synergic adjuvant
effect with IL-12, enhancing Th1 polarization in adult (AD) mice, we administered IL-36β to …
[CITATION][C] The Lrp1-Shca complex shifts the insulin-like growth factor 1 (Igf-1) signaling pathway from differentiation to clonal expansion during adipogenesis
M Mlih, E Woldt, RL Matz… - …, 2011 - … 40-44, PO BOX 133, CH-4010 …
[HTML][HTML] Rev-erb-α regulates atrophy-related genes to control skeletal muscle mass
…, A Danckaert, S Lancel, B Pourcet, E Woldt… - Scientific Reports, 2017 - nature.com
The nuclear receptor Rev-erb-α modulates hepatic lipid and glucose metabolism,
adipogenesis and thermogenesis. We have previously demonstrated that Rev-erb-α is also
an important regulator of skeletal muscle mitochondrial biogenesis and function, and …
adipogenesis and thermogenesis. We have previously demonstrated that Rev-erb-α is also
an important regulator of skeletal muscle mitochondrial biogenesis and function, and …
[CITATION][C] Atherosclerosis severity is independent of endogenous IL-33 signaling
…, G Palmer, E Rodriguez, E Woldt… - …, 2014 - … SCIENCE LTD 24-28 OVAL RD …
