CD38, a transmembrane glycoprotein with ADP-ribosyl cyclase activity, catalyses the
formation of Ca 2+ signalling molecules, but its role in the neuroendocrine system is
unknown. Here we show that adult CD38 knockout (CD38-/-) female and male mice show …

Hydrolysis of the membrane phospholipid phosphatidylinositol-4, 5-bisphosphate (PtdIns (4,
5) P 2) produces two prospective intracellular messengers: inositol-l, 4, 5-trisphosphate
(InsP 3), which releases Ca 2+" from intracellular stores 1; and diacylglycerol (DG), which …

The primary structures of two muscarinic acetylcholine receptor (mAChR) species,
designated as mAChR I and mAChR II, have been elucidated by cloning and sequence
analysis of DNAs complementary to the porcine cerebral and cardiac messenger RNAs …

The complete amino acid sequences of two potassium channel proteins from NG108‐15
neuroblastoma‐glioma hybrid cells have been deduced by cloning and sequencing the
cDNAs. One of these proteins (NGK2) is structurally more closely related to the Drosophila …

Abstract M-type (KCNQ2/3) potassium channels are suppressed by activation of G q/11-
coupled receptors, thereby increasing neuronal excitability. We show here that rat KCNQ2
can bind directly to the multivalent A-kinase-anchoring protein AKAP150. Peptides that block …

The addition of bradykinin to NG108-15 cells results in a transient hyperpolarization
followed by prolonged cell depolarization. Injection of inositol 1, 4, 5-trisphosphate or Ca2+
into the cytoplasm of NG108-15 cells also elicits cell hyperpolarization followed by …

The mechanism of phagocytic elimination of dying cells in Drosophila is poorly understood.
This study was undertaken to examine the recognition and engulfment of apoptotic cells by
Drosophila hemocytes/macrophages in vitro and in vivo. In the in vitro analysis, l (2) mbn …

The neurobiological basis of autism spectrum disorder (ASD) remains poorly understood.
Given the role of CD38 in social recognition through oxytocin (OT) release, we hypothesized
that CD38 may play a role in the etiology of ASD. Here, we first examined the …

Serotonin activates adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6. 1.1] of
NCB-20 neuroblastoma--brain hybrid cells with an activation constant of 530 nM, but has
little or no effect on cellular cyclic AMP or cyclic GMP content of NIE-115 neuroblastoma or …

A cDNA clone which encodes a monocarboxylate transporter (ratMCT1) was isolated from a
rat small intestinal cDNA library, which was screened by using full-length MCT1 cDNA of
Chinese hamster ovary cells. The ratMCT1 cDNA was sequenced and predicted a protein of …